Ohtaki Hirokazu

Affiliation and department：
Other affiliations (1)：

Tokyo City University Faculty of Engineering Department of Medical Engineering

Research theme for competitive and other funds (30)：

2022 - 2026 損傷脊髄に生着しやすい骨髄間葉系幹細胞の特性化と予見的選択法の開発
2021 - 2026 The contribution of Pin1 on thamamic regulation and age-related neurodegenerative diseases
2024 - 2025 Inhibitory mechanism of neuroinflammation associated with heat stroke in PACAP.
2022 - 2025 老化に伴い増加するエオシン陽性封入体の構成タンパク質同定と相分離の観察
2021 - 2025 神経ペプチドPACAPの熱中症による全身および神経炎症抑制機構の解明

2020 - 2024 Invention study for preventing dementia: enriched odor exposure enhance newborn neurons in hippocampus?

2019 - 2023 マウス熱中症モデルにおける凝固線溶異常・血管内皮傷害の検討敗血症と何が違うのか

2017 - 2021 Demonstration of transplanted Bone marrow derived mesenchymal stem/progenitor cells (MSCs) homing and co-effect of kinetic therapy on the spinal cord injury

2016 - 2020 Determination of hMSCs-derived neuroprotective factors on brain ischemia and the glial modulating mechanism

2016 - 2020 The contribution between cognitive impairment and accumulation of insoluble protein in brain after temporary stress.

2015 - 2020 The neuroprotective effect of recombinat thrombomoduline on the rodent model of heatstroke.

2014 - 2018 brain damage after heat stroke in mice

2014 - 2018 Development of new strategy for rheumatoid arthritis and osteoarthritis applying human mesenchymal stem cells

2013 - 2017 Relationship between transplanted bone marrow mesenchymal stem/progenitor cells and marrow tissues after spinal cord injury

2013 - 2017 Analysis for therapeutic effects of mesenchymal stem/progenitor cells on neuropsychological disorder after traumatic brain injury.

2013 - 2016 Repairing mechanism of human mesenchymal stem cells (hMSCs) via immune regulation on ischemia brain injury

2012 - 2016 PACAP38 suppresses cortical damage in mice with traumatic brain injury by enhancing antioxidant activity.

2011 - 2016 Basic and translational research for protection of neurodegeneration.

2013 - 2015 New strategy for protecting and therapy of neuronal cell degeneration by intranasal infusion of proteins and neuropeptide

2011 - 2013 Monitoring of neuroinflammation and creation of new strategy after spinal cord injury.

2010 - 2012 Neuroprotective mechanism of bone marrow mesenchymal stem cells via immune regulation of brain

2010 - 2011 The scavengering effect of edaravone to nitric monoxide in mice traumatic brain injury

2009 - 2011 Establishment of human bone marrow mesenchymal stem cells(hMSCs) culture with serum free medium and evaluation of spinal cord regeneration

2008 - 2010 Demonstration of PACAP on protection of delayed neuronal cell death and its molecular mechanism of neuroregeneration.

2008 - 2008 健常成人骨髄由来間葉系幹細胞のマイクログリアの制御による脳梗塞抑制機構の解明

2005 - 2006 Free Radical Monitoring of Brain Injury and their Basic Studies

2003 - 2004 腸管上皮細胞増殖・組織再生因子としてのグレリン

2003 - 2004 腫瘍壊死因子(TNF-α)による神経細胞死誘導とその分子制御機構

2002 - 2003 Therapeutic Angiogenesis for the Cerebral Ischemic Disease and Vascular Dementia

2000 - 2001 Therapeutic Angiogenesis for the Chronic Cerebral Ishemic Disease & Vascular Dementia.

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Papers (153)：

Kaoru Yanagisawa, Kazuyuki Miyamoto, Yoshihiro Wakayama, Satoru Arata, Keisuke Suzuki, Motoyasu Nakamura, Hiroki Yamaga, Takuro Miyazaki, Kazuho Honda, Kenji Dohi, et al. Exacerbation of Hepatic Damage in Endothelial Aquaporin 1 Transgenic Mice after Experimental Heatstroke. Biomedicines. 2024. 12. 9
吉川輝, 大滝博和, 宮本和幸, 金承革, 長谷和徳, 吉田真, 上條翔太郎, 上村佐和, 小岩信義, 泉崎雅彦. 左大脳皮質損傷モデルマウスに対する中等度の走行運動課題と麻痺側足関節の運動機能回復と非麻痺側足関節の代償運動の関係性. 基礎理学療法学. 2024. 26. Suppl.1. 153-153
Akira Yoshikawa, Makito Iizuka, Mitsuko Kanamaru, Shotaro Kamijo, Hirokazu Ohtaki, Masahiko Izumizaki. Exercise evaluation with metabolic and ventilatory responses and blood lactate concentration in mice. Respiratory physiology & neurobiology. 2023. 104163-104163
Masaoka Yuri, Yoshikawa Akira, Kamimura Sawa, Ohtaki Hirokazu, Honma Motoyasu, Sakikawa Kei, Kamijo Shotaro, Yoshida Masaki, Izumizaki Masahiko. Odor associated with memory-recalling could be a preventive method for cognitive impairment: investigating in human and animal studies(タイトル和訳中). The Journal of Physiological Sciences. 2023. 73. Suppl.1. 83-83
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa. Downregulation of the gene expression of Cyp2c29 and Cyp3a11 by cecal ligation and puncture-induced sepsis is associated with interleukin-6. International immunopharmacology. 2023. 117. 110039-110039

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MISC (166)：

吉川輝, 大滝博和. 脳損傷モデル動物の運動評価および運動処方運動機能障害からの回復に向けた基礎研究. 細胞. 2023. 55. 10. 816-820
芦野隆, 中村祐輝, 大滝博和, 岩倉洋一郎, 沼澤聡. Role of interleukin-6 in the downregulation of hepatic drug transporters by cecal ligation and puncture-induced sepsis. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
瀬戸口潔, 河田紋実, 指宿綾子, 柳岡大悟, 大滝博和, 馬場広子, 林明子. IVIg製剤は末梢ミエリンタンパク質特異的IgG抗体を含む. 末梢神経. 2022. 33. 2. 319-319
宮本和幸, 大滝博和, 中村元保, 島田拓哉, 柳沢薫, 山荷大貴, 鈴木恵輔, 本田一穂, 八木正晴, 土肥謙二. マウス熱中症モデルを用いた熱中症後の小脳白質・Purkinje細胞・シナプス傷害の検討. 日本救急医学会雑誌. 2022. 33. 10. 825-825
鈴木恵輔, 宮本和幸, 島田拓哉, 柳澤薫, 山荷大貴, 中村元保, 大滝博和, 本田一穂, 土肥謙二. マウス熱中症モデルを用いた体温調節機構の検討. 日本脳低温療法・体温管理学会誌. 2022. 25. 1. 36-36

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Patents (5)：

Lectures and oral presentations (37)：

Increase of CCL5 after spinal cord injury might contributes to axonal regeneration.
(2018)
中枢神経障害時における移植骨髄由来間葉系幹細胞とグリア細胞の相互作用の解析
(第123回日本解剖学会総会・学術集会 2018)
PACAP promotes sweat secretion in eccrine gland via PAC1R.
(13th International Symposium on VIP, PACAP and Related Peptides 2017)
Regulation of CCL2 (MCP-1) expression from human mesenchymal stem/stromal cells after ischemia through inflammatory cytokines.
(2017)
PACAP increases hematopoietic stem/progenitor cellar proliferation in murine bone marrow via nerve innervation
(2017)

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Professional career (1)：

博士(医学) (昭和大学)

Work history (1)：

2022/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy School of Pharmacy professor

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