Rchr
J-GLOBAL ID：201801021325639224   Update date: Apr. 30, 2024

Hanashima Akira

ハナシマ アキラ | Hanashima Akira
Affiliation and department：
Kawasaki Medical School First Department of Physiology

About Kawasaki Medical School First Department of Physiology


Job title： Assistant Professor
Research field  (5)： Biomedical engineering ,  Physiology ,  Animals: biochemistry, physiology, behavioral science ,  Evolutionary biology ,  Biogeoscience
Research keywords  (6)： Muscle elastic protein Connectin ,  giant protein ,  Heart ,  muscle ,  mechanobiology ,  Evolutional physiology
Research theme for competitive and other funds  (28)：
  • 2024 - 2027 心筋細胞内張力受容伝達システムの分子基盤と心不全治療への展開
  • 2021 - 2025 哺乳類心筋細胞のT管膜構造の維持機構の解明と進化的意義の探求
  • 2022 - 2024 冬眠中の心筋細胞のT管膜維持機構の解明による革新的心不予防法の創出
  • 2021 - 2024 A paradigm shift in fetal oxygen regulation implicated in heart regeneration.
  • 2020 - 2024 Creation of innovative myocardial regeneration strategy with soft and highly dividing cardiomyocytes
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Papers (21)：
  • Yuu Usui, Akira Hanashima, Ken Hashimoto, Misaki Kimoto, Momoko Ohira, Satoshi Mohri. Comparative analysis of ventricular stiffness across species. Physiological Reports. 2024. 12. 8
  • Kehao Wang, Yutian Pu, Leran Chen, Masato Hoshino, Kentaro Uesugi, Naoto Yagi, Xiaoyong Chen, Yuu Usui, Akira Hanashima, Ken Hashimoto, et al. Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains. Experimental eye research. 2024. 241. 109858-109858
  • Yuu Usui, Misaki Kimoto, Akira Hanashima, Ken Hashimoto, Satoshi Mohri. Cardiac hemodynamics and ventricular stiffness of sea-run cherry salmon (Oncorhynchus masou masou) differ critically from those of landlocked masu salmon. PLOS ONE. 2022. 17. 11. e0267264-e0267264
  • Ken Hashimoto, Aya Kodama, Momoko Ohira, Misaki Kimoto, Reiko Nakagawa, Yuu Usui, Yoshihiro Ujihara, Akira Hanashima, Satoshi Mohri. Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15. iScience. 2022. 25. 5. 104337-104337
  • Nishikawa A, Hanashima A, Nakayama S, Ogasawara M, Kimura S. Transcripts of the nebulin gene from Ciona heart and their implications for the evolution of nebulin family genes. Gene. 2019. 716. 144036 (7 pages)
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MISC (10)：
  • 橋本 謙, 臼居 優, 花島 章, 氏原嘉洋, 塚田孝祐, 毛利 聡. 酸素環境と心臓再生. Medical Science Digest (Structural Heart Disease インターベンションの近未来). 2022. 48. 10. 30 (494)-33 (497)
  • Mohri Satoshi, Hanashima Akira, Ujihara Yoshihiro, Hashimoto Ken. Mammals and birds have independently evolved the 4-chambered hearts: : Analysis of connectin which works as molecular spring in striated muscle. Transactions of Japanese Society for Medical and Biological Engineering. 2017. 55. 5. 443-443
  • Hashimoto Ken, Honda Takeshi, Hanashima Akira, Ujihara Yoshihiro, Mohri Satoshi. Fam64a is essential for low oxygen-induced fetal cardiomyocyte proliferation. Transactions of Japanese Society for Medical and Biological Engineering. 2016. 54. 27. S222-S222
  • Hanashima Akira, Hashimoto Ken, Ujihara Yoshihiro, Honda Takeshi, Yobimoto Tomoko, Mohri Satoshi. Elastic structures of connectin in the hearts with coronary and non-coronary circulation. Transactions of Japanese Society for Medical and Biological Engineering. 2016. 54. 28. S396-S396
  • Akira Hanashima, Naruki Sato, Sumiko Kimura, Takashi Sakurai, Takashi Murayama. Proteins in Striated Muscles that Transcribed from the Contiguous Region of Connectin Gene. BIOPHYSICAL JOURNAL. 2015. 108. 2. 420A-421A
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Lectures and oral presentations  (122)：
  • Atrioventricular hearts and molecular spring connectin in the mollusc oyster
    (2024)
  • 甲殻類心臓と巨大弾性蛋白質コネクチンの統合的解析
    (生体運動研究合同班会議2024 2024)
  • 心房心室型心臓とバネ分子コネクチン 軟体動物カキ心臓の比較生理
    (日本生理学会第75回中国四国地方会 2023)
  • 軟体動物カキ心臓の構造と 弾性蛋白質コネクチン
    (第94回日本動物学会大会 2023)
  • 心臓進化:軟体動物カキと 脊椎動物の共通性と 筋弾性蛋白質コネクチン
    (第25回日本進化学会大会 2023)
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Education (3)：
  • 2007 - 2009 Chiba University Graduate School of Science
  • 2005 - 2007 Chiba University Graduate School of Science and Technology
  • 2001 - 2005 Chiba University Faculty of Science Department of Biology
Professional career (1)：
  • Ph.D. (Science)
Work history (6)：
  • 2019/04 - 現在 Kawasaki Medical School Senior Assistant Professor
  • 2015/06 - 2019/03 Assistant Professor, Kawasaki Medical school
  • 2013/04 - 2015/05 JSPS research fellow PD, Juntendo University
  • 2010/06 - 2013/03 Visiting research fellow, Heidelberg University
  • 2010/04 - 2013/03 Project research fellow, Chiba University
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Association Membership(s) (4)：
日本進化学会 ,  日本生理学会 ,  日本生体医工学会 ,  日本動物学会
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