Kokubu Eitoyo

Affiliation and department：

Research field (1)： Bacteriology

Research keywords (1)： Microbiology

Research theme for competitive and other funds (21)：

2023 - 2026 Treponema denticolaの運動制御による感染予防
2023 - 2026 口腔細菌Capnocytophaga属がもたらす口腔扁平上皮癌悪性化機構の解明
2022 - 2026 付着上皮再生による歯周病治療のComplete regenerationへの挑戦
2022 - 2025 Augumentation of virulence by interaction between periodontopathic bacteia
2022 - 2025 Development of a novel host-directed therapy for periodontitis based on the bacteria-environment-host interactions

2022 - 2025 ケミカルジェネティクスを応用したインプラント周囲軟組織発現遺伝子の機能解析と創薬

2020 - 2023 Treponema denticolaの細胞侵入機構と免疫回避機構の解明

2019 - 2022 Basic study on the development of host-directed miRNA therapy as a novel treatment for periodontal disease

2019 - 2022 Develop the new drugs for peri-implantitis prevention by drug repositioning methods

2018 - 2021 Investigation of epigenetic change in the epithelial cells induced by periodontopathic bacteria

2018 - 2021 口腔細菌カプノサイトファガをトリガー細菌とする歯周病発症機構の解明

2017 - 2021 Complete regeneration of periodontal tissue by junctional epithellium regeneration

2016 - 2019 Response of epithelial cells infected by Treponema denticola

2016 - 2019 Periodontitis as a multifactorial disease: Investigation on the novel host regulation therapy

2015 - 2018 Microbiome analysis of apical periodontitis and cellulitis in oral cavity

2014 - 2017 Development of new periodontal disease prevention method using ECF sigma factors of periodontal pathogenic bacteria

2013 - 2016 Investigation of the molecular mechanisms involved in host cell invasion by periodontal pathogens under the exposure by cigarette smoke.

2012 - 2015 Investigation of virulence of microorganisms in polymicrobial infection

2012 - 2015 The behavior of epithelial cells for the invasion by Treponema denticola

2010 - 2012 A study on the mechanisms involved in the invasion of host cells by periodontal pathogens and the novel method for its regulation

2009 - 2010 The development of implant material by controlling adhesive protein

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Papers (105)：

Yumi Numata, Yuichiro Kikuchi, Toru Sato, Kazuko Okamoto-Shibayama, Yutaro Ando, Yuri Miyai-Murai, Eitoyo Kokubu, Kazuyuki Ishihara. Novel transcriptional regulator OxtR1 regulates potential ferrodoxin in response to oxygen stress in Treponema denticola. Anaerobe. 2024
Hideo Yonezawa, Eitoyo Kokubu, Yuichiro Kikuchi, Kazuyuki Ishihara. Complete genome sequence of Fusobacterium vincentii strain TDC100 isolated from an apical periodontitis lesion. Microbiology Resource Announcements. 2024
Yukiko Yamaguchi-Kuroda, Yuichiro Kikuchi, Eitoyo Kokubu, Kazuyuki Ishihara. Porphyromonas gingivalis diffusible signaling molecules enhance Fusobacterium nucleatum biofilm formation via gene expression modulation. Journal of Oral Microbiology. 2023. 15. 1
米澤英雄, 菊池有一郎, 国分栄仁, 石原和幸. Streptococcus mutansロイテリサイクリン産生機構の解析. Journal of Oral Biosciences Supplement. 2023. 2023. [O2-05]
米澤英雄, 国分栄仁, 菊池有一郎, 三戸部治郎, 石原和幸. Streptococcus mutansロイテリサイクリン産生の発現メカニズムの解析. 日本細菌学雑誌. 2023. 78. 1. 130-130

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MISC (96)：

吉川幸輝, 国分栄仁, 国分栄仁, 北村友里恵, 久永理央, 久永理央, 山下慶子, 齋藤淳, 齋藤淳, 石原和幸. Porphyromonas gingivalis Hgp44の付着ドメインがTreponema denticolaとのバイオフィルム形成に与える影響. 歯科学報. 2022. 122. 2
木村麻記, 黄地健仁, 佐藤涼一, 国分栄仁, 黒田英孝, 安藤正之, 河野恭佑, 野村幸恵, 澁川義幸, 岩崎美友. 象牙芽細胞における細胞膜Ca2+-ATPaseは象牙質石灰化を調節する(Plasma membrane Ca2+-ATPase in human and rat odontoblasts regulates dentin mineralization). Journal of Oral Biosciences Supplement. 2021. 2021. 313-313
木村麻記, 黄地健仁, 佐藤涼一, 国分栄仁, 黒田英孝, 黒田英孝, 安藤正之, 河野恭佑, 野村幸恵, 澁川義幸. Plasma membrane Ca²⁺-ATPase in human and rat odontoblasts regulates dentin mineralization. Journal of Oral Biosciences Supplement (Web). 2021. 2021
深澤俊也, 深澤俊也, 北村友里恵, 菊池有一郎, 菊池有一郎, 国分栄仁, 国分栄仁, 齋藤淳, 齋藤淳, 石原和幸, et al. Treponema denticolaの環境ストレス応答機構の解明. 歯科学報. 2020. 120. 2
北村友里恵, 深澤俊也, 菊池有一郎, 菊池有一郎, 国分栄仁, 国分栄仁, 石原和幸, 石原和幸, 齋藤淳, 齋藤淳. Treponema denticola TDE_0127遺伝子は酸素ストレス応答と病原性に関与する. 歯科学報. 2020. 120. 2

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Education (1)：

Professional career (1)：

Work history (5)：

2015/04 - 現在 Tokyo Dental College Department of Microbiology
2009/05 - 2015/04 Tokyo Dental College Department of Microbiology
2007/04 - 2009/04 Tokyo Dental College Oral Health Science Center
2006/06 - 2007/03 University of British Columbia Department of Oral Biological and Medical Sciences
2005/04 - 2007/03 Tokyo Dental College Oral Health Science Center Research Assistant

Association Membership(s) (2)：

日本歯科基礎医学会 , 日本細菌学会

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