Ijichi Hideaki

Research field (1)： Gastroenterology

Research theme for competitive and other funds (29)：

2021 - 2024 Precision medicine using patient-derived organoid of pancreatic cancer
2021 - 2024 腸内細菌叢による免疫・神経シグナルを介した膵臓癌進展機序の解明
2021 - 2024 Role of BMP signaling in tumor progression in pancreatic cancer using genetically engineered mouse model
2020 - 2023 膵発癌モデルを用いた微小環境の新規標的制御による膵癌制御法の開発
2020 - 2023 膵発癌モデルを用いたVCAM-1阻害による膵癌の全身病態制御機序の解明

2017 - 2020 Targeting VCAM-1 for contributing to the prognosis of pancreatic cancer: the effect and underlying mechanisms

2016 - 2019 Oncogenetic process by the complexed system due to heterochromatin-derived RNA

2016 - 2019 Roles of BMP signaling in pancreatic cancer initiation and progression using a genetically-engineered mouse model

2016 - 2019 Impact of chemokine signals in the tumor microenvironment of pancreatic cancer

2015 - 2018 microRNA expression during the multiple steps of pancreatic carcinogenesis

2015 - 2017 患者由来膵癌異種移植腫瘍を用いたエピジェネティック因子を標的とした新規治療の開発

2014 - 2017 Analysis of a novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion

2015 - 2016 膵癌におけるBMPシグナルの役割の検討

2014 - 2016 膵癌の治療奏功性・抵抗性におけるVCAM-1の機能解析と臨床における有用性

2013 - 2016 Fibloblast response to the tumor in the desmoplasia involved in the malignant potential of pancreatic cancer

2013 - 2016 Multi-step carcinogenesis due to non-coding repetitive RNA expression

2012 - 2015 An investigation of histone modifications that modulate malignant properties of pancreatic cancer.

2012 - 2015 Molecular targeting therapy against intracellular signaling network in gallbladder cancer

2012 - 2015 Functional analysis of pancreatic cancer-specific antigen highly expressed throughout the disease stage

2012 - 2015 Elucidation of the biological function of non-coding repeat RNA in pancreatic cancer using mouse models

2011 - 2013 Analysis of roles of autophagy in pancreatic cancer using mouse models

2010 - 2012 The impact of activated PI3K signal on pancreatic cancer

2010 - 2012 The relationship between chronic injury and the origin of the liver tumor analyzed using mouse model

2010 - 2012 Targeting tumor microenvironment as a novel therapeutic strategy for pancreatic cancer using a genetically-engineered mouse model

2010 - 2012 Roles of NF-kappaB activation in gastrointestinal tumorigenesis

2008 - 2010 Approaching the cell of origin for pancreatic ductal adenocarcinoma by using genetically-engineered mice

2008 - 2009 遺伝子改変マウス膵発癌モデルを用いた膵癌の腫瘍間質相互作用の解析

2003 - 2003 プロテオーム解析による胆嚢・膵臓癌の戦略的個別治療

2002 - 2002 プロテオーム解析による胆嚢・膵臓癌の戦略的個別治療

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Papers (160)：

Tomoya Kuramochi, Makoto Sano, Ichie Kajiwara, Yukino Oshima, Tomoaki Itaya, Jinsuk Kim, Yoshimi Ichimaru, Osamu Kitajima, Atsushi Masamune, Hideaki Ijichi, et al. Effects of tramadol via a μ-opioid receptor on pancreatic ductal adenocarcinoma in vitro and in vivo. Regional Anesthesia & Pain Medicine. 2023. rapm-2023
Tomoharu Yamada, Ryosuke Tateishi, Miwako Iwai, Minoru Tanaka, Hideaki Ijichi, Makoto Sano, Kazuhiko Koike, Tomoki Todo. Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors. Molecular therapy oncolytics. 2023. 28. 31-43
Takahiro Seimiya, Tatsunori Suzuki, Takuma Iwata, Takahiro Kishikawa, Kazuma Sekiba, Chikako Shibata, Kazunaga Ishigaki, Hiroaki Fujiwara, Hiroki Oyama, Sachiko Kanai, et al. Combination of serum human satellite RNA and miR-21-5p levels as a biomarker for pancreatic cancer. iScience. 2023. 26. 2. 106021-106021
Tsuyoshi Hamada, Hiroki Oyama, Yousuke Nakai, Shuichi Tange, Junichi Arita, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, et al. Clinical Outcomes of Intraductal Papillary Mucinous Neoplasms With Dilatation of the Main Pancreatic Duct. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2023. 21. 7. 1792-1801
Tomoaki Itaya, Makoto Sano, Ichie Kajiwara, Yukino Oshima, Tomoya Kuramochi, Jinsuk Kim, Yoshimi Ichimaru, Osamu Kitajima, Atsushi Masamune, Hideaki Ijichi, et al. Mirogabalin improves cancer-associated pain but increases the risk of malignancy in mice with pancreatic cancer. Pain. 2022. Publish Ahead of Print. 7. 1545-1554

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MISC (99)：

Hiroyuki Kato, Keisuke Tateishi, Keisuke Yamamoto, Dousuke Iwadate, Hiroaki Fujiwara, Takuma Nakatsuka, Koji Miyabayashi, Yotaro Kudo, Ijichi Hideaki, Kazuhiko Koike, et al. A multi-omics study in patient-derived organoids reveals MNX1-HNF1B axis to be indispensable for intraductal mucinous papillary neoplasm lineages. CANCER RESEARCH. 2021. 81. 22. 47-48
Makoto Sano, Ryota Takahashi, Hideaki Ijichi, Kazunaga Ishigaki, Tomoharu Yamada, Koji Miyabayashi, Suguru Mizuno, Takuma Nakatsuka, Yasuo Tanaka, Yohei Masugi, et al. Blocking VCAM-1 inhibits pancreatic tumor progression and cancer-associated thrombosis/thromboembolism. CANCER SCIENCE. 2021. 112. 490-490
大島雪乃, 佐野誠, 市丸嘉, 梶原一絵, 板谷朋亮, 蔵持智也, 金眞淑, 伊地知秀明, 伊地知秀明, 石井敬基, et al. 膵癌モデルに対するミダゾラムの疼痛緩和・抗腫瘍・抗炎症効果. 日本癌学会学術総会抄録集(Web). 2021. 80th
多田稔, 大山博生, 濱田毅, 立石敬介, 高木馨, 金井祥子, 佐藤達也, 鈴木辰典, 白田龍之介, 石垣和祥, et al. 【IPMN大全】IPMNの基本的事項 IPMNの自然史(併存膵癌の頻度を含めて). 胆と膵. 2020. 41. 臨増特大. 1189-1191
高見真, 長谷川陽子, 関根里恵, 伊地知秀明, 窪田直人. 低体重、ADL低下を認める肺移植後患者において管理栄養士による長期的な栄養指導が有用であった一例. 学会誌JSPEN. 2020. 2. Suppl.1. 1572-1572

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Professional career (1)：

MD, PhD (The University of Tokyo)

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