Research field (2)：
Digestive surgery
, Tumor diagnostics and therapeutics
Research keywords (2)：
Gastroenterological Surgery
, Gene therapy
Research theme for competitive and other funds (16)：
2023 - 2026 脊椎脊髄腫瘍に対する腫瘍融解ウイルス療法の確立
2022 - 2025 Immune molecular mechanism for enhancing antitumor potency of a next-generation oncolytic virus by pre-immunization
2021 - 2024 Exploration of metabolic factors to inhibit tumor-specific p53 gene therapy in pancreatic cancer
2019 - 2022 Development of a next-generation viral agent targeting immunosuppression by crosstalk in the pancreatic cancer microenvironment
2017 - 2020 Imaging system for progression of gastrointestinal cancer and its application to anti-metastasis therapy
2016 - 2019 Preclinical study of tumor-specific p53 gene therapy against refractory pancreatic cancer
2016 - 2019 Development of the Dual fluorescent cytology with tumor-specific viruses for gastrointestinal cancer precision medicine
2015 - 2017 Analysis for intraperitoneal cancer microenvironment to elucidate the biological mechanism of peritoneal metastasis of gastrointestinal cancer
2014 - 2017 Development of anti-metastasis therapy in the inflammation-related gastric cancer progression
2014 - 2016 Novel targeting therapy to cancer-associated fibroblasts for treatment-resistant carcinomas
2013 - 2016 Development of novel microRNA-based therapy against KRAS/BRAF-mutant colorectal cancer
2013 - 2016 Photoimmunotherapy for gastrointestinal cancer
2011 - 2013 Fluorescence-guided detection and genetic analysis of circulating tumor cells
2011 - 2013 Tumor suppressor FHIT regulates tumor invasion of pancreatic cancer cells via inhibiting association of Ezrin and Actin cytoskeleton
2011 - 2012 Circulating Tumor Cell of Gastrointestinal Stromal Tumor
2010 - 2012 Induction of autophagic cell death via microRNA-mediated gene regulatory network
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Papers (145)：
Masaaki Akai, Kazuhiro Noma, Takuya Kato, Seitaro Nishimura, Hijiri Matsumoto, Kento Kawasaki, Tomoyoshi Kunitomo, Teruki Kobayashi, Noriyuki Nishiwaki, Hajime Kashima, et al. Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity. British journal of cancer. 2024
Koji Uotani, Hiroshi Tazawa, Joe Hasei, Tomohiro Fujiwara, Aki Yoshida, Yasuaki Yamakawa, Toshinori Omori, Kazuhisa Sugiu, Tadashi Komatsubara, Hiroya Kondo, et al. Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus. PloS one. 2024. 19. 2. e0298292
Naoto Hori, Hiroshi Tazawa, Yuncheng Li, Tomohiro Okura, Satoru Kikuchi, Shinji Kuroda, Toshiaki Ohara, Kazuhiro Noma, Masahiko Nishizaki, Yasuo Urata, et al. Intraperitoneal Administration of p53-armed Oncolytic Adenovirus Inhibits Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells. Anticancer research. 2023. 43. 11. 4809-4821
Yoshihiko Kakiuchi, Shinji Kuroda, Nobuhiko Kanaya, Shunsuke Kagawa, Hiroshi Tazawa, Toshiyoshi Fujiwara. Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses. Expert opinion on therapeutic targets. 2023. 1-10
宇根 悠太, 菊地 覚次, 田澤 大, 黒田 新士, 大原 利章, 野間 和広, 香川 俊輔, 藤原 俊義. 胃がん腹膜転移の生物学的解明を目的とした腹膜構造3Dモデルの開発(Development of the 3D model of peritoneum structure to explore the biology of gastric cancer peritoneal metastasis). 日本癌学会総会記事. 2023. 82回. 1858-1858
1998/04 - 2000/03 Hokkaido University School of Medicine
1997/04 - 1998/03 Akita University University Hospital
1995/04 - 1997/03 秋田県厚生連雄勝中央病院 外科 研修医
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Committee career (3)：
2022/06 - 現在 日本バイオセラピィ学会 評議員
2019/01 - 現在 日本癌学会 評議員
2017/07 - 現在 日本遺伝子細胞治療学会 評議員
Awards (4)：
2013/06 - 岡山医学会 がん研究奨励賞
2012/06 - 日本遺伝子治療学会 アンジェスMG賞
2010/05 - 財団法人 富山県ひとづくり財団 とやま賞(医薬部門)
2007/09 - 日本疾患モデル学会 優秀発表賞
Association Membership(s) (9)：
日本がん予防学会
, 米国癌学会
, 日本バイオセラピィ学会
, 日本消化器癌発生学会
, JAPAN SOCIETY OF CLINICAL ONCOLOGY
, 日本遺伝子細胞治療学会
, THE JAPANESE CANCER ASSOCIATION
, THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL SURGERY
, JAPAN SURGICAL SOCIETY
