Rchr
J-GLOBAL ID:201801021449824984
Update date: Sep. 18, 2024
Yamamoto Ken'ichi
ヤマモト ケンイチ | Yamamoto Ken'ichi
Affiliation and department:
Job title:
Assistant Professor
Homepage URL (1):
http://www.okayama-u.ac.jp/user/cellbiol/
Research field (1):
Molecular biology
Research keywords (4):
細胞生物学
, 分子生物学
, Cell biology
, Molecular biology
Research theme for competitive and other funds (8):
- 2023 - 2026 難治性潰瘍での変性コラーゲンの局在証明、再上皮化遅延の病態解明とその治療法開発
- 2023 - 2026 S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
- 2022 - 2025 乾癬、アトピー性皮膚炎におけるMCAMの意義探求とその制御製剤による病態制御
- 2020 - 2023 β3インテグリン遺伝子導入ヒト表皮角化細胞を用いた難治性潰瘍に対する新規再生医療
- 2020 - 2023 新規S100A8/A9阻害分子の発見に基づいたがん脳指向転移の機構解明とその制御
- 2019 - 2022 S100A11-RAGEシグナルを標的とした膵臓がん微小環境の解析とその治療
- 2017 - 2020 Mechanistic analysis of an unidentified downstream signals of S100A8/A9 receptors that play a crucial role in acquisition of metastatic force and formation of cancer microenvironment.
- 2013 - 2016 Clarification of the mechanism of the chronicity of allergic diseases and establishment of the thrapeutic strategy against it
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Papers (48):
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Yuze Wang, Aye Moh-Moh-Aung, Tianyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Ken-Ichi Yamamoto, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa. Exosomal delivery of miR-200b-3p suppresses the growth of hepatocellular carcinoma cells by targeting ERG- and VEGF-mediated angiogenesis. Gene. 2024. 148874-148874
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Jin Zhou, Hitoshi Murata, Nahoko Tomonobu, Naoko Mizuta, Atsuko Yamakawa, Ken-Ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi. Correction: S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway. In vitro cellular & developmental biology. Animal. 2024
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Jin Zhou, Hitoshi Murata, Nahoko Tomonobu, Naoko Mizuta, Atsuko Yamakawa, Ken-Ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi. S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway. In vitro cellular & developmental biology. Animal. 2024
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Fan Jiang, Youyi Chen, Nahoko Tomonobu, Rie Kinoshita, Ni Luh Gede, Yoni Komalasari, Carlos Ichiro, Kasano-Camones, Kazumi Ninomiya, Hitoshi Murata, et al. Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis. Front. Oncol. Sec. Molecular and Cellular Oncology. 2024. 14. 1371307
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Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, et al. Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface. Frontiers in Oncology. 2024. 14
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MISC (32):
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合原勇馬, 友信奈保子, 木下理恵, 村田等, 山本健一, 難波正義, 許南浩, 公文裕己, 阪口政清. A novel function of REIC protein on tumor suppression through the downregulation of PD-L1 on cancer cells. 組織培養研究(Web). 2023. 41. 2
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山本健一, 平林大輔, 丸山顕嘉, 友信奈保子, 木下理恵, KOMALASARI Ni Luh Gade Yoni, 村田等, 合原勇馬, 江帆, 山内明, et al. The Zn2+-bound form of ZEB1 plays a crucial part in the promotion of invasiveness in breast cancer cells. 組織培養研究(Web). 2023. 41. 2
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友信奈保子, 木下理恵, 合原勇馬, KOMALASARI Ni Luh Gede Yoni, JIANG Fan, 村田等, 山本健一, 山内明, 近藤英作, 豊岡伸一, et al. HRG suppresses the S100A8/A9-mediated metastasis of melanoma cells. 組織培養研究(Web). 2023. 41. 2
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高橋徹多, 友信奈保子, KOMALASARI Ni Luh Gede Yoni, 合原勇馬, 山本健一, 木下理恵, 村田等, 阪口政清. Discovery of the mechanism of breast cancer progression focusing on cell-surface annexin A2/S100A11 binding. 組織培養研究(Web). 2023. 41. 2
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村田等, 安藤隆幸, 安井優, 越智俊樹, 友信奈保子, 山本健一, 木下理恵, 阪口政清. Development of inhibitors of axonal degeneration-inducing molecule SARM1 using human iPS cell-derived neurons and animal models. 組織培養研究(Web). 2023. 41. 2
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Patents (2):
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リン酸化SARM1、抗体、SARM1リン酸化阻害剤、神経変性患者の予防または治療薬、スクリーニング方法、SARM1改変体及び使用
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遺伝子発現用カセット及びその産生物
Lectures and oral presentations (29):
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Nuclear PD-L1 facilitates disseminative activity by suppressing MCRIP1 in triple-negative breast cancer cells.
(2023)
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Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that targets the cell-surface annexin A2
(2023)
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糞便微生物移植治療から見出した腸内の放線菌の 生理活性評価
(日本組織培養学会第95回大会 2023)
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TLR4 accelerates bladder cancer progression upon interaction with S100A8/A9
(2023)
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REIC タンパク質によるPD-L1 制御を介した抗腫瘍機序の解明
(日本組織培養学会第95回大会 2023)
more...
Education (3):
- - 2013 Okayama University
- - 2013 Okayama University
- - 2007 Okayama University of Science Faculty of Science Department of Applied Science
Professional career (3):
- 博士(医学) (岡山大学)
- 修士(医学) (岡山大学)
- 理学士(生物) (岡山理科大学)
Work history (2):
- 2015 - 現在 - 岡山大学医歯薬学総合研究科 助教
- 2013 - 2015 佐賀大学医学部分子生命科学講座分子医化学分野 博士研究員
Committee career (1):
- 2017/04 - 2023/03 岡山大学大学院医歯薬学総合研究科 医歯科学専攻(修士課程)学務委員会 学生募集・就職支援推進部会
Association Membership(s) (3):
日本がん免疫学会
, 日本癌学会
, 日本組織培養学会
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