Rchr
J-GLOBAL ID：201901000044148213   Update date: May. 15, 2024

Siro Simizu

シミズ シロウ | Siro Simizu
Affiliation and department：
Keio University Faculty of Science and TechnologyDepartment of Applied Chemistry

About Keio University Faculty of Science and TechnologyDepartment of Applied Chemistry


Homepage URL  (1)： https://www.applc.keio.ac.jp/~simizu/index.html
Research field  (1)： Applied biochemistry
Research keywords  (3)： Glycoscience ,  Cancer Chemotherapy ,  Chemical Biology
Research theme for competitive and other funds  (14)：
  • 2018 - 2021 Identification of novel enzymes for C-mannosylation and analysis of its substrate proteins
  • 2012 - 2015 Development of novel drug for bone-related diseases using Pirin inhibitors
  • 2011 - 2014 Bio-imaging of peritoneal metastasis and molecular design of inhibitors
  • 2008 - 2014 Administration of the group grant "Intracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic"
  • 2008 - 2012 Analysis of intracellular logistics by chemical biology
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Papers (112)：
  • Tomoe Matagawa, Yukiko Sasazawa, Koki Agui, Motoki Fujimaki, Sayaka Kawano, Akihiro Ogura, Ken-Ichi Takao, Masayuki Igarashi, Siro Simizu. Antiproliferative activities through accelerating autophagic flux by basidalin and its analogs in human cancer cells. Bioorganic & medicinal chemistry letters. 2024. 104. 129713-129713
  • Ryota Kawahara, Tomoko Usami, Satoko Arakawa, Hiroki Kamo, Takehiro Suzuki, Ryosuke Komatsu, Hiroyuki Hara, Yuki Niwa, Erina Shimizu, Naoshi Dohmae, et al. Biogenesis of fibrils requires C-mannosylation of PMEL. The FEBS Journal. 2023. 290. 22. 5373-5394
  • Toshitaka Okamura, Takaaki Sato, Ayaha Kage, Yuya Okuyama, Erina Kato, Tomoe Matagawa, Sayaka Kawano, Siro Simizu, Noritaka Chida. Synthesis and Evaluation of Saponins with All-Nitrogenated Sugars. Synlett. 2023
  • Satoshi Yoshimoto, Takehiro Suzuki, Naoki Otani, Daisuke Takahashi, Kazunobu Toshima, Naoshi Dohmae, Siro Simizu. Destabilization of vitelline membrane outer layer protein 1 homolog (VMO1) by C -mannosylation. FEBS Open Bio. 2023. 13. 3. 490-499
  • Sayaka Kawano, Tomoe Matagawa, Yutaka Matsuda, Takayuki Koyama, Kazuki Miura, Masaya Nakata, Yoko Saikawa, Siro Simizu. Biological evaluation for anti-inflammatory effect of africane-type sesquiterpenoids. Bioorganic & Medicinal Chemistry. 2022. 68. 116857-116857
ｍore...
MISC (9)：
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Education (3)：
  • 1995 - 1998 Keio University
  • 1993 - 1995 Keio University
  • 1989 - 1993 Keio University Faculty of Science and Technology Department of Applied Chemistry
Professional career (1)：
  • 博士(工学) (慶應義塾大学)
Work history (6)：
  • 2017/04 - 現在 Keio University Faculty of Science and Technology, Department of Applied Chemistry
  • 2012/04 - 2017/03 Keio University Faculty of Science and Technology, Department of Applied Chemistry
  • 2010/04 - 2012/03 Keio University Faculty of Science and Technology, Department of Applied Chemistry
  • 2000/04 - 2007/03 理化学研究所 抗生物質研究室 研究員
  • 1998/04 - 2000/03 理化学研究所 抗生物質研究室 基礎科学特別研究員
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Awards (2)：
  • 2011 - 日本がん転移学会 研究奨励賞
  • 2004 - 日本癌学会 奨励賞
Association Membership(s) (6)：
INTERNATIONAL CHEMICAL BIOLOGY SOCIETY ,  THE JAPANESE ASSOCIATION FOR METASTASIS RESEARCH ,  THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH ,  JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER ,  THE JAPANESE CANCER ASSOCIATION
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