Rchr
J-GLOBAL ID：201901000289314399
Update date: Sep. 01, 2020
Shimizu Kazuya
シミズ カズヤ | Shimizu Kazuya
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Affiliation and department：
Kobe University Graduate School of Health Sciences
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Detailed information
Other affiliations (1)：
国立病院機構神戸医療センター
内科系診療部長
Research field (1)：
Tumor diagnostics and therapeutics
Research keywords (2)：
Stem cell
, Pancreatic cancer
Research theme for competitive and other funds (2)：
2017 - 2020 K-ras/MMP-10シグナル伝達を標的とした抗癌剤耐性膵癌の新規治療法の確立
2014 - 2017 ヒト膵癌幹細胞とES/iPS細胞を使った微小環境構築に関する研究
Papers (9)：
Akihito Machinaga, Yuichi Hori, Kazuya Shimizu, Kyohei Okahara, Emmy Yanagita, Makoto Miyoshi, Tomoo Itoh, Ken Sasai. Xenografts Derived From Patientsʼ Ascites Recapitulate the Gemcitabine Resistance Observed in Pancreatic Cancer Patients. Pancreas. 2019. 48. 10. 1294-1302
Kazuya Shimizu, Takaaki Nishiyama, Yuichi Hori. Gemcitabine enhances Kras-MEK-induced matrix metalloproteinase-10 expression via histone acetylation in gemcitabine-resistant pancreatic tumor-initiating cells. Pancreas. 2017. 46. 2. 268-275
Kazuya Shimizu. Identification of a novel subpopulation of tumor-initiating cells from gemcitabine-resistant pancreatic ductal adenocarcinoma patients. PLoS One. 2013. 8. 11. e81283-1-13
Izuru Ohtsubo, Tetsuo Ajiki, Yuichi Hori, Sae Murakami, Kazuya Shimizu, Tomoo Itoh, Michio Shimizu, Takumi Fukumoto, Yonson Ku. Distinctive expression of CD133 between intraductal papillary neoplasms of the bile duct and bile duct adenocarcinomas. HEPATOLOGY RESEARCH. 2012. 42. 6. 574-582
Kazuya Shimizu. Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells. Pathobiology. 2011. 78. 4. 181-92
ｍore...
Lectures and oral presentations (5)：
抗がん剤耐性の膵臓癌に対する脂質メディエーターの効果
(第51回日本臨床分子形態学会 2019)
ヒト膵癌細胞由来エクソソームは肝転移を亢進する
(第28回日本がん転移学会 2019)
抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立とその解析
(第50回日本臨床分子形態学会総会・学術集会 2018)
抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立とその解析
(第49回日本膵臓学会大会 2018)
がん遺伝子を導入したマウス膵臓組織幹細胞はがん幹細胞様の表現型を示す
(第40回日本分子生物学会 2017)
Education (1)：
1992 - 1996 Osaka University
Professional career (1)：
医学博士 (大阪大学医学研究科)
Association Membership(s) (4)：
THE JAPAN DIABETES SOCIETY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, JAPAN PANCREAS SOCIETY
, The Japanese Society of Gastroenterology
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