Shiraishi Yuichi

シライシユウイチ | Shiraishi Yuichi

Affiliation and department：
Homepage URL (1)： http://friend1ws.github.io/

Research field (1)： Biological, health, and medical informatics

Research theme for competitive and other funds (19)：

2023 - 2026 肺癌における酸化ストレス応答系の新規破綻機序の解明と標的治療の探索
2022 - 2026 Cellular survival strategy through ATR-dependent DNA replication stress tolerance
2021 - 2024 大規模トランスクリプトームからの自律的知能獲得システム基盤の開発
2020 - 2023 小細胞肺癌における酸化ストレス応答系の破綻機序の解明
2019 - 2022 Elucidation of disease biology and tissue specificity by trans-layer omics analysis and whole-genome sequencing

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Papers (261)：

Junji Koya, Tomohiko Tanigawa, Kota Mizuno, Haryoon Kim, Yuta Ito, Mitsuhiro Yuasa, Kentaro Yamaguchi, Yasunori Kogure, Yuki Saito, Sumito Shingaki, et al. Modeling NK-cell lymphoma in mice reveals its cell-of-origin and microenvironmental changes and identifies therapeutic targets. Nature communications. 2024. 15. 1. 9106-9106
Qingbo S Wang, Takanori Hasegawa, Ho Namkoong, Ryunosuke Saiki, Ryuya Edahiro, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Shotaro Chubachi, Yugo Takahashi, et al. Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance. Nature genetics. 2024. 56. 10. 2054-2067
Shota Kato, Aiko Sato-Otsubo, Wataru Nakamura, Masahiro Sugawa, Ai Okada, Kenichi Chiba, Nao Takasugi, Tomoya Irikura, Moe Hidaka, Masahiro Sekiguchi, et al. Genome profiling with targeted adaptive sampling long-read sequencing for pediatric leukemia. Blood Cancer Journal. 2024. 14. 1
Shinju Iyoda, Kenichi Yoshida, Kota Shoji, Nana Ito, Miu Tanaka, Yasuhito Nannya, Genki Yamato, Shinichi Tsujimoto, Norio Shiba, Yasuhide Hayashi, et al. KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia. Leukemia. 2024. 38. 7. 1609-1612
Yutaro Mori, Yoshie Okimoto, Hiroaki Sakai, Yusuke Kanda, Hirokazu Ohata, Daisuke Shiokawa, Mikiko Suzuki, Hiroshi Yoshida, Haruka Ueda, Tomoyuki Sekizuka, et al. Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer. Cell reports. Medicine. 2024. 5. 5. 101532-101532

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MISC (230)：

Tomonori Hirano, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Toshihiko Masui, Shinji Uemoto, Sachiko Minamiguchi, Hironori Haga, Yuichi Shiraishi, Satoru Miyano, Norimitsu Uza, et al. Genetic analysis of metachronous pancreatic cancers. CANCER SCIENCE. 2021. 112. 658-658
Yotaro Ochi, Kenichi Yoshida, Ko Sasaki, Noriko Hosoya, Yusuke Shiozawa, Yasuhito Nannya, Takayuki Ishikawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, et al. Genetic profiling and prognosis of blast crisis in chronic myeloid leukemia. CANCER SCIENCE. 2021. 112. 454-454
June Takeda, Kenichi Yoshida, Akinori Yoda, Yasuhito Nannya, Masahiro Nakagawa, Yotaro Ochi, Ayana Kon, Tetsuichi Yoshizato, Yusuke Shiozawa, Yuichi Shiraishi, et al. JAK STAT Pathway is a Promising Therapeutic target in Acute Erythroid Leukemia. CANCER SCIENCE. 2021. 112. 453-453
Yasuhide Takeuchi, Hiromichi Suzuki, Kenichi Yoshida, Yuichi Shiraishi, Nobuyuki Kakiuchi, Yusuke Shiozawa, Yoshikage Inoue, Kenichi Chiba, Hideki Makishima, Satoru Miyano, et al. Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma. CANCER SCIENCE. 2021. 112. 850-850
奥田瑠璃花, 南谷泰仁, 越智陽太郎, 蝶名林和久, 蝶名林和久, 牧島秀樹, 永田安伸, 真田昌, 白石友一, 宮野悟, et al. ETNK1変異の有無を特徴とするder(1;7)(q10;p10)を伴う骨髄異形成症候群. 日本癌学会学術総会抄録集(Web). 2021. 80th

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Books (15)：

「がん全エキソーム・ゲノム情報解析」、がんゲノムペディア:77のキーワードで理解するゲノム医療とゲノム研究
羊土社 2024 ISBN:9784758121309
「Open APIを活用したゲノムデータ共有基盤について」、実験医学増刊 Vol.41 No.15 マルチオミクスデータ駆動時代の疾患研究がん、老化、生活習慣病最新のオミクス統合で挑む標的探索と病態解明
2023
「がんゲノムデータの共有基盤」、実験医学増刊 Vol.41 No.7 ポストGWAS時代の遺伝統計学オミクス解析と機械学習でヒト疾患を俯瞰する
2023
「クラウドを使ったゲノム解析環境の構築」、実験医学 40巻 6号スパコン・クラウドを生命科学に使う
羊土社 2022
「がんゲノムにおけるスプライシング変異の検出」、医学のあゆみ 2675巻 5号
医歯薬出版 2020

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Lectures and oral presentations (55)：

APIを利用した全ゲノム解析利活用基盤
(第1回がん・難病全ゲノム合同班会議 2024)
Toward Building an Analysis Platform for the Recapitulation of Complete Cancer Genomes
(第14回国際ゲノム会議 Complete human genome and beyond 2023)
ロングリードターゲットシークエンスの包括的解析ワークフローと遺伝性がん患者のゲノム解析
(第82回日本癌学会学術総会 2023)
On detection of somatic structural variation in highly repetitive regions using long-read sequencing data
(第82回日本癌学会学術総会 2023)
ロングリードシークエンスを用いたがんゲノムの後天的構造異常検出
(第34回バイオメディカル研究会 2023)

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Education (4)：

2005 - 2008 The Graduate University for Advanced Studies School of Multidisciplinary Sciences Department of Statistical Science
2003 - 2005 東京大学大学院情報理工学系研究科数理情報学専攻
2001 - 2003 The University of Tokyo The Faculty of Engineering Department of Mathematical Engineering and Information Physics
1999 - 2001 The University of Tokyo College of Arts and Sciences

Professional career (1)：

統計科学 (総合研究大学院大学)

Work history (8)：

2020/04 - 現在国立がん研究センター研究所ゲノム解析基盤開発分野分野長
2018/04 - 2020/03 国立がん研究センター研究所細胞情報学分野ユニット長
2014/04 - 2018/03 The University of Tokyo The Institute of Medical Science
2014/04 - 2014/11 シカゴ大学人類遺伝学科客員研究員
2012/06 - 2014/03 The University of Tokyo The Institute of Medical Science

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