Maru Yoshiaki

マルヨシアキ | Maru Yoshiaki

Affiliation and department：

Research field (1)： Tumor biology

Research theme for competitive and other funds (12)：

2023 - 2026 Elucidation of the mechanisms underlying drug-resistance and identification of candidate drugs of gynecologic neuroendocrine tumors using patient-derived organoids
2022 - 2025 Elucidation of the mechanisms underlying drug-resistance and development of predictive biomarker using patient-derived ovarian cancer organoids
2022 - 2025 Elucidation of the mechanisms underlying drug-resistance and development of therapeutic strategy of refractory cervical cancer using patient-derived organoids
2022 - 2025 Development of amplified gene-specific alkylator as a novel therapeutic agent using patient-derived organoids from solid tumors
2021 - 2024 Organoid-based modeling of gastric carcinogenesis and elucidation of its mechanism

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Papers (22)：

Yoshiaki Maru, Mami Kohno, Kiyomi Suzuka, Akiko Odaka, Mari Masuda, Akinobu Araki, Makiko Itami, Naotake Tanaka, Yoshitaka Hippo. Establishment and characterization of multiple patient-derived organoids from a case of advanced endometrial cancer. Human cell. 2024
Jihang Yao, Keizo Takenaga, Nobuko Koshikawa, Yuki Kida, Jason Lin, Takayoshi Watanabe, Yoshiaki Maru, Yoshitaka Hippo, Seigi Yamamoto, Yuyan Zhu, et al. Anticancer effect of a pyrrole-imidazole polyamide-triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells. International journal of cancer. 2023. 152. 5. 962-976
Daisuke Hoshi, Emiri Kita, Yoshiaki Maru, Hiroyuki Kogashi, Yuki Nakamura, Yasutoshi Tatsumi, Osamu Shimozato, Kazuyoshi Nakamura, Kentaro Sudo, Akiko Tsujimoto, et al. Derivation of Pancreatic Acinar Cell Carcinoma Cell Line HS -1 as a Patient-derived Tumor Organoid. Cancer Science. 2022
Rikako Ishigamori, Mie Naruse, Akihiro Hirata, Yoshiaki Maru, Yoshitaka Hippo, Toshio Imai. The potential of organoids in toxicologic pathology: Histopathological and immunohistochemical evaluation of a mouse normal tissue-derived organoid-based carcinogenesis model. Journal of toxicologic pathology. 2022. 35. 3. 211-223
Yoshiaki Maru, Yoshitaka Hippo. Twists and turns in Kras-driven tumor initiation. Aging. 2021. 13. 22. 24477-24479

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MISC (51)：

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Lectures and oral presentations (34)：

オルガノイド発がんモデルが明らかにする子宮内膜の発がんおよび転移促進的な遺伝学的相互作用
(日本癌学会総会記事 2020)
婦人科がんの発生・病態・治療に関する最新の知見オルガノイドを用いた婦人科がんの統合的研究(Recent advances in generation, biology, and treatment of gynecologic cancer An integrated study of gynecologic cancers by organoid-based approaches)
(日本癌学会総会記事 2019)
婦人科がんの発生・病態・治療に関する最新の知見オルガノイドを用いた婦人科がんの統合的研究(Recent advances in generation, biology, and treatment of gynecologic cancer An integrated study of gynecologic cancers by organoid-based approaches)
(日本癌学会総会記事 2019)
患者由来卵巣がんからのオルガノイド培養
(日本婦人科腫瘍学会雑誌 2019)
患者由来卵巣がんからのオルガノイド培養
(日本婦人科腫瘍学会雑誌 2019)

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Professional career (1)：

Work history (3)：

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