Research field (4):
Hygiene and public health (non-laboratory)
, Hygiene and public health (laboratory)
, Pharmaceuticals - health and biochemistry
, Molecular biology
Research keywords (3):
signal transduction
, metal
, stress response
Research theme for competitive and other funds (8):
2022 - 2025 不良タンパク質凝集体アグリソーム集積因子のカドミウム毒性における役割の解析
2019 - 2022 鉄イオン依存性尿細管細胞死における新規制御因子の解析
2017 - 2019 Analysis of the regulatory mechanisms of cadmium-induced cell death
2014 - 2017 Stress signaling pathways responsible for the cell survival and death following exposure to toxic metals
2015 - 2017 Analysis of the effects of prolonged cadmium exposure on the malignant progression
2012 - 2014 Analysis of heavy metal stress sensing system in Caenorhabditis elegans
2013 - 2013 神経ペプチドによる個体レベルでの環境汚染物質防御誘導
2010 - 2011 個体レベルにおけるJNK型MAPK経路によるストレス応答シグナル伝達機構
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Papers (15):
Kota Fujiki, K. Tanabe, S. Suzuki, A. Mochizuki, M. Mochizuki-Kashio, T. Sugaya, T. Mizoguchi, M. Itoh, A. Nakamura-Ishizu, H. Inamura, et al. Blockage of Akt activation suppresses cadmium-induced renal tubular cellular damages through aggrephagy in HK-2 cells. Scientific Reports. 2024. 14. 1
Makiko Mochizuki-Kashio, Noriko Otsuki, Kota Fujiki, Sherif Abdelhamd, Peter Kurre, Markus Grompe, Atsushi Iwama, Kayoko Saito, Ayako Nakamura-Ishizu. Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells. Frontiers in Oncology. 2023. 13
Kota FUJIKI. Involvement of Notch1 and ALK4/5 Signaling Pathways in Renal Tubular Cell Death: Their Application to Clarification of Cadmium Toxicity. Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene). 2020. 75. n/a-n/a
Fujiki K, Inamura H, Sugaya T, Matsuoka M. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms. Cell Death & Differentiation. 2019. 26. 2371-2385
Matsuoka M, Fujiki K. Mechanisms underlying the development of pulmonary fibrosis induced by paraquat exposure: Signaling pathways regulating the epithelial-mesenchymal transition. Current Topics in Toxicology. 2018. 14. 21-27