Rchr
J-GLOBAL ID：201901001669137399   Update date: Jun. 20, 2024

Hashimoto Ryota

Hashimoto Ryota
Research field  (1)： Pathobiochemistry
Research theme for competitive and other funds  (8)：
  • 2022 - 2025 炎症性マクロファージのiNOS制御による動脈硬化進展抑制および再生血管変性予防
  • 2020 - 2022 ビタミンB2の過剰摂取は動脈硬化を悪化させるのか
  • 2019 - 2022 非必須脂肪酸システインによる動脈硬化進展メカニズムの解明及び再生血管に与える影響
  • 2018 - 2021 Does excessive cysteine intake exacerbate the atherosclerosis?
  • 2013 - 2017 Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional food
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Papers (26)：
  • Ryota Hashimoto, Hiroshi Koide, Youichi Katoh. MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling. Cell death discovery. 2023. 9. 1. 374-374
  • Mutsumi Yokota, Yutaro Yoshino, Mitsuko Hosoi, Ryota Hashimoto, Soichiro Kakuta, Takahiro Shiga, Kei-Ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, et al. Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines. Frontiers in cell and developmental biology. 2023. 11. 1171440-1171440
  • Ryota Hashimoto, Hiroshi Koide, Youichi Katoh. Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages. Journal of pharmacological sciences. 2023. 151. 1. 46-53
  • Yukiko Sasazawa, Sanae Souma, Norihiko Furuya, Yoshiki Miura, Saiko Kazuno, Soichiro Kakuta, Ayami Suzuki, Ryota Hashimoto, Hiroko Hirawake-Mogi, Yuki Date, et al. Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2. The EMBO Journal. 2022. 41. 22
  • Ryota Hashimoto, Sachin A. Gupte. G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation. Vascular Pharmacology. 2022. 144. 106976-106976
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MISC (17)：
  • 橋本 良太, 宮本 祐希, 柿木 亮, 中村 京子, 代田 浩之, 岡田 隆夫, 加藤 洋一. 骨髄由来マクロファージにおいてglucocorticoidはJAK-STATシグナル伝達経路を抑制することによりAc-LDLの取込みを低下させる(Glucocorticoid Decreases Uptake of Ac-LDL through Suppression of JAK-STAT Pathway in Bone Marrow-derived Macrophages). 日本循環器学会学術集会抄録集. 2019. 83回. PJ058-3
  • 橋本 良太, 柿木 亮, 中村 京子, 伊藤 誠悟, 代田 浩之, 岡田 隆夫, 加藤 洋一. LPS誘発性アテローム性動脈硬化症はマクロファージのMAPK/ERK経路を介するCD204発現の増大によりもたらされる(LPS-induced Atherosclerosis is Provided by the Enhancement of CD204 Expression through the MAPK/ERK Pathway in Macrophages). 日本循環器学会学術集会抄録集. 2018. 82回. PJ035-3
  • 橋本 良太, 柿木 亮, 中村 京子, 伊藤 誠悟, 代田 浩之, 岡田 隆夫, 加藤 洋一. LPS誘発性アテローム性動脈硬化症はマクロファージのMAPK/ERK経路を介するCD204発現の増大によりもたらされる(LPS-induced Atherosclerosis is Provided by the Enhancement of CD204 Expression through the MAPK/ERK Pathway in Macrophages). 日本循環器学会学術集会抄録集. 2018. 82回. PJ035-3
  • T. Iesaki, T. Takeuchi, M. Okano, R. Hashimoto, R. Kakigi, Y. Ishii, T. Okada. FUCOIDAN, A LIGAND OF SCAVENGER RECEPTOR CLASS A, CAUSES VASCULAR RELAXATION THROUGH A NITRIC OXIDE/CGMP-MEDIATED PATHWAY IN RAT AORTA. ATHEROSCLEROSIS. 2014. 235. 2. E36-E36
  • Takafumi Iesaki, Tomoaki Takeuchi, Megumi Okano, Ryota Hashimoto, Ryo Kakigi, Yuko Ishii, Takao Okada. A Ligand of Scavenger Receptor Class A Causes Vascular Relaxation Through an Activation of Endothelial Nitric Oxide Synthase in Rat Aorta. CIRCULATION. 2012. 126. 21
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