Research keywords (2)：
Ubiquitination
, DNA repair
Research theme for competitive and other funds (4)：
2017 - 2020 DNA複製とストレス応答におけるHERC2の機能解析
2014 - 2017 The Feature of BRCA1 function on DNA Damage Repair within higher-order chromatin structure
2011 - 2014 The role of BRCA1-HERC2 complex in DNA replication fork progression and stress response
2008 - 2011 A study on the molecular mechanisms of BRCA1-mediated cell cycle regulation from a comprehensive protein interaction analysis approach
Papers (34)：
Zhu J, Wu W, Togashi Y, Nihira NT, Johmura Y, Zhu D, Nakanishi M, Miyoshi Y, Ohta T. Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance. Breast Cancer. 2022. Online ahead of print
Tencer AH, Liu J, Zhu J, Burkholder NT, Zhang Y, Wu W, Strahl BD, Ohta T, Kutateladze TG. The ZZ domain of HERC2 is a receptor of arginylated substrates. Sci Rep. 2022. 12. 6063
Suzuki Y, Wu W, Ohta T, Hayashi S. Molecular targeted drugs resistance impairs double-strand break repair and sensitizes ER-positive breast cancer to PARP inhibitors. Breast Cancer. 2022. 29. 1. 77-91
Katsuki Y, Abe M, Park SY, Wu W, Yabe H, Yabe M, Attikum HV, Nakada S, Ohta T, Seidman MM, et al. RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair. Cell Rep. 2021. 37. 4. 109879
Suzuki N, Johmura Y, Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, et al. TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis. Autophagy. 2021. 17. 11. 3776-3793
Ohta T, Wu W. Molecular Basis of BRCA1 and BRCA2: Homologous Recombination Deficiency and Tissue-Specific Carcinogenesis. Hereditary Breast and Ovarian Cancer(著書). 2021. 15-29
