Research theme for competitive and other funds (2)：
2021 - 2024 トリプルネガティブ乳癌の薬剤耐性獲得におけるIL-26の機能解明
2018 - IL-26を標的とした新規癌転移制御療法の確立
Papers (15)：
Ryo Hatano, Hayato Nakamura, Ayako Yamamoto, Haruna Otsuka, Takumi Itoh, Nao Hosokawa, Jinghui Yu, Sedigheh Ranjbar, Yuta Hasegawa, Tsutomu Sato, et al. An abnormal increase in CD26(-)CD28(-) cytotoxic effector CD4 and CD8 T cell populations in patients with systemic lupus erythematosus. International immunology. 2024
Ryo Hatano, Takumi Itoh, Haruna Otsuka, Harumi Saeki, Ayako Yamamoto, Dan Song, Yuki Shirakawa, Satoshi Iyama, Tsutomu Sato, Noriaki Iwao, et al. Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease. American Journal of Transplantation. 2022
Eriko Komiya, Mitsutoshi Tominaga, Ryo Hatano, Yuji Kamikubo, Sumika Toyama, Hakushun Sakairi, Kotaro Honda, Takumi Itoh, Yayoi Kamata, Munehiro Tsurumachi, et al. Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. Journal of Allergy and Clinical Immunology. 2021. 149. 3. 1085-1096
Aiko Ono-Ohmachi, Satoki Yamada, Satoru Uno, Masato Tamai, Kohei Soga, Shotaro Nakamura, Nobuyuki Udagawa, Yuko Nakamichi, Masanori Koide, Yoshikazu Morita, et al. Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance. Mucosal Immunology. 2021. 14. 6. 1335-1346
Takumi Itoh, Ryo Hatano, Yoshiya Horimoto, Taketo Yamada, Dan Song, Haruna Otsuka, Yuki Shirakawa, Shuji Mastuoka, Noriaki Iwao, Thomas M. Aune, et al. IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells. Cell Death & Disease. 2021. 12. 6
Eriko Komiya-Suyama, Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Yasushi Suga, Utako Kimura, Taketo Ya-Mada, Mitsutoshi Tominaga, Kenji Takamori, et al. THE REGULATION OF PRURITUS IN PSORIASIS AND ATOPIC DERMATITIS - A POSSIBLE ROLE FOR CD26/DPPIV. ACTA DERMATO-VENEREOLOGICA. 2017. 97. 8. 1008-1009
IL-26 facilitates angiogenesis and skin inflammation via inducing FGF2 production in a murine model of imiquimod-induced psoriasis
(2017)
Education (1)：
2014 - 2017 Juntendo University Graduate School of Health and Sports Science.
Work history (3)：
2022/04 - 現在 Graduate School of Medicine, Juntendo University Department of Therapy Development and Innovation for Immune Disorders and Cancers
2018/04 - 2022/03 Juntendo University Graduate School of Medicine
2017/04 - 2022/03 Juntendo University Graduate School of Medicine
Awards (2)：
2019/08 - Janssen Psoriasis Award Biological Effects of IL-26 on T Cell-Mediated Skin Inflammation, Including Psoriasis
2018/10 - 一般財団法人 日本産業科学研究所 研究助成金
Association Membership(s) (5)：
日本呼吸器学会
, JAPANESE SOCIETY FOR PSORIASIS RESEARCH
, THE JAPANESE CANCER ASSOCIATION
, JAPAN COLLEGE OF RHEUMATOLOGY
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
