Wakita Takaji

Research field (1)： Virology

Research theme for competitive and other funds (27)：

2020 - 2023 C型肝炎のDAA治療によるSVR達成後の肝病態形成に関わる基礎的研究
2017 - 2020 Reversible and irreversible damages of hepatocyte after DAA treatment for HCV carriers
2014 - 2017 Analysis of mechanism of HCV particle formation, secretion, and associated cellular factor
2012 - 2017 Virus and host interaction on plus-strand RNA virus replication
2012 - 2017 Molecular basis of host cell competency in virus infection

2013 - 2015 The mechanism of infection of enterovirus71: through the receptor PSGL-1.

2011 - 2012 Analysis of hepatitis C virus sequence quasi species by NGS

2009 - 2011 Cell culture system for genotype1b hepatitis C virus

2009 - 2010 C型肝炎ウイルスの感染増殖および粒子形成における脂質の役割

2007 - 2008 Analysis of the role of lipid in viral life cycles

2006 - 2008 Analysis of factors involved in viral replication efficiency and search for novel anti -virals using HCV culture systems.

2007 - 2007 C型肝炎ウイルスの感染初期過程に関与する宿主因子の探索

2006 - 2007 Analysis of virus adaptations in the novel HCV cell culture and infection system

2006 - 2007 感染性C型肝炎ウイルス粒子による肝細胞への遺伝子デリバリーシステムの構築

2005 - 2006 Production and Analysis of Chimeric Hepatitis C Virus

2004 - 2006 HCVレプリコンシステムを用いた薬剤感受性規定領域の検討

2004 - 2005 Analysis of replication of Hepatitis C Virus using highly efficient replication system

2004 - 2005 Viral genomic region of Hepatitis C Virus which determine viral replication and drug sensitivity

2002 - 2003 デングウイルス感染マウスモデルを用いたデング出血熱の病態解析

2002 - 2003 Construction and analysis of viral hepatocarcinogenesis model using HCV transgenic mouse model

2001 - 2002 C型肝炎ウイルストランスジェニックマウスを用いた肝炎及び肝癌発症機構の解析

1999 - 2001 Establishment and Comparison of HCV Specific CTL and Tumor-Antigen Specific CTL.

1999 - 2000 Construction and analysis of viral hepatocarcinogenesis model using HCV transgenic mouse model

1997 - 1998 Analysis of viral counter regulation against host's defense mechanism for viral infection using HCV transgenic mouse model

1996 - 1997 Analysis of persistent infection mechanism of RNA virus

1996 - 1996 C型肝炎ウイルス蛋白質の構造と機能の多様性についての解析

1996 - 1996 C型肝炎ウイルス・トランスジェニックマウスの作製とその分子生物学的、免疫学的解析

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Papers (538)：

Tetsuya Inoue, Yuichiro Yamamoto, Kaoru Sato, Yuko Okemoto-Nakamura, Yoshimi Shimizu, Motohiko Ogawa, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Mika K. Kaneko, et al. Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies. iScience. 2024. 27. 4. 109363-109363
Shogo Nakajima, Koichi Watashi, Takanobu Kato, Masamichi Muramatsu, Takaji Wakita, Noriko Tamura, Shin-Ichiro Hattori, Kenji Maeda, Hiroaki Mitsuya, Yoshiaki Yasutake, et al. Correction for Nakajima et al., "Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations". Journal of virology. 2024. 98. 3. e0182323
Jinta Asami, Jae-Hyun Park, Yayoi Nomura, Chisa Kobayashi, Junki Mifune, Naito Ishimoto, Tomoko Uemura, Kehong Liu, Yumi Sato, Zhikuan Zhang, et al. Structural basis of hepatitis B virus receptor binding. Nature structural & molecular biology. 2024. 31. 3. 447-454
Eriko Morino, Sohtaro Mine, Noriko Tomita, Yukari Uemura, Yosuke Shimizu, Sho Saito, Tetsuya Suzuki, Nobumasa Okumura, Haruka Iwasaki, Junko Terada, et al. Mpox Neutralizing Antibody Response to LC16m8 Vaccine in Healthy Adults. NEJM evidence. 2024. 3. 3. EVIDoa2300290
Yorihiro Nishimura, Kei Sato, Yoshio Koyanagi, Takaji Wakita, Masamichi Muramatsu, Hiroyuki Shimizu, Jeffrey M Bergelson, Minetaro Arita. Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface. PLoS pathogens. 2024. 20. 2. e1012022

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MISC (203)：

水上智晴, 白砂圭崇, 深澤秀輔, 長瀬翔太朗, 清水芳実, 清水芳実, 脇田隆字, 鈴木哲朗, 谷英樹, 近藤昌夫, et al. Isolation and characterization of a substrain of hepatitis C virus capable of infecting iPS cells. 日本薬学会年会要旨集(Web). 2023. 143rd
上野みなみ, 田中純子, 沢辺元司, 村松正道, 脇田隆字, 相崎英樹. 感染症法に基づくサーベイランスデータによる国内の急性C型肝炎の発生動向解析(1999年-2020年). 肝臓. 2023. 64. Supplement 1
青柳東代, 飯島尋子, 若江亨祥, 渡士幸一, 鈴木亮介, 政木隆博, 政木隆博, 杉山真也, 坪田昭人, 島田紀朋, et al. C型肝炎ウイルス除去後の病態,発癌のメカニズム. 肝細胞研究会プログラム・抄録集. 2023. 30th
伊達朋子, 渡邉則幸, 杉山真也, 溝上雅史, 鈴木亮介, 相崎英樹, 村松正道, 脇田隆字, 脇田隆字. Establishment of infectious genotype 5 HCVcc. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
青柳東代, 飯島尋子, 松田麻未, 若江亨祥, 渡士幸一, 鈴木亮介, 政木隆博, 杉山真也, 坪田昭人, 島田紀朋, et al. Correlation between hepatocellular organelles, gene expression abnormalities and carcinogenesis following elimination of hepatitis C virus. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th

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Professional career (1)：

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