Kobayashi Sho

Affiliation and department：
Job title： Associate Professor

Research field (3)： Pathobiochemistry , Medical biochemistry , Molecular biology

Research keywords (4)：シスチントランスポーター , システイン , グルタチオン , レドックス制御

Research theme for competitive and other funds (14)：

2023 - 2027 Regulatory mechanism of ferroptosis via cystine/glutamate transporter regulated by food derived ingredients
2022 - 2025 新規フェロトーシス抑制因子CNDP2によるシステイン再利用系の生理機能の解明
2021 - 2025 Search for food-derived functional ingredients that control iron-dependent cell death ferroptosis and their effects on the glutathione-redox system
2021 - 2022 β-アミノイソ酪酸ががん細胞増殖におよぼす影響とそのメカニズムについて
2020 - 2022 Elucidation of physiological functions of glutathione-related metabolites and its metabolic enzymes in ferroptosis

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Papers (40)：

Shiho Sato, Ferry Ferdiansyah Sofian, Dradre Atakuru Paulin, Sho Kobayashi, Takuya Koseki, Yoshihito Shiono. Polyketides isolated from endophyte Fusarium armeniacum and their cytotoxic activities. PHYTOCHEMISTRY LETTERS. 2023. 54. 32-39
Shiho Sato, Ferry Ferdiansyah Sofian, Dradre Atakuru Paulin, Sho Kobayashi, Takuya Koseki, Yoshihito Shiono. Integracide derivatives produced by endophyte Fusarium armeniacum M-3 isolated from Digitaria ciliaris. Natural product research. 2023. 1-8
Chikako Yokoyama, Sho Kobayashi, Yumi Harada, Yuki Nishino, Junichi Fujii, Taro Tachibana. Generation of Rat Monoclonal Antibody for Mouse Nucleolin by Immunization of Ferroptosis-Induced Hepa 1-6 Cells. Monoclonal antibodies in immunodiagnosis and immunotherapy. 2022. 41. 5. 255-259
Takujiro Homma, Tsukasa Osaki, Sho Kobayashi, Hideyo Sato, Junichi Fujii. d-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione. Journal of clinical biochemistry and nutrition. 2022. 71. 1. 48-54
Soju Kimura, Tsukasa Osaki, Takujiro Homma, Sotai Kimura, Sho Kobayashi, Masaki Nakane, Satoshi Miyata, Hiroshi Itoh, Kaneyuki Kawamae, Junichi Fujii. The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency. Life sciences. 2022. 304. 120694-120694

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MISC (4)：

Junichi Fujii, Takujiro Homma, Sho Kobayashi, Prashant Warang, Manisha Madkaikar, Malay B. Mukherjee. Erythrocytes as a preferential target of oxidative stress in blood. FREE RADICAL RESEARCH. 2021. 55. 5. 562-580
Fujii J, Homma T, Kobayashi S, Seo HG. Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease. World J Biol Chem. 2018. 9. 1. 1-15
藤井順逸, 本間拓二郎, 小林翔. グルタチオン:古いレドックス分子の新たな役割. TH LUNG perspectives. 2016. 421-425
Marcus Conrad, Irina Ingold, Katalin Buday, Sho Kobayashi, Jose Pedro Friedmann Angeli. ROS, thiols and thiol-regulating systems in male gametogenesis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2015. 1850. 8. 1566-1574

Books (2)：

Glutathione and related compounds produced by the glutathione-synthesizing patyway. In Glutathione: Biosynthesis, Functions and Biological Implications
Nova Science Publishers Inc, 2019
Chapter 11: Ascorbic Acid as a Multifunctional Nutrient in Mammals; Our Understanding based on Studies using Genetically Modified Mice. In "Ascorbic Acid: Properties, Synthesis and Applications"(Emma Parsons, ed.)
Nova Science Publishers, Inc, 2016

Lectures and oral presentations (23)：

黄柏抽出物はシスチン欠乏条件下の培養によるフェロトーシスを抑制する
(第96回日本生化学会 2023)
xCT遺伝子欠損胚性線維芽細胞の生存を可能にする食品由来成分の探索
(第96回日本生化学会 2023)
細胞内グルタチオン・レドックス系に影響を与える食品由来成分の探索
(2023年度日本農芸化学会東北支部シンポジウム 2023)
食品からフェロトーシスを阻害する成分の探索
(EMBO Workshop Ferroptosis: When metabolism meets cell death 2023)
細胞周期の進行に伴う活性酸素生成はフェロトーシスの実行に重要である
(第96回日本薬理学会)

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Education (3)：

Work history (2)：

Awards (2)：

2021/05 - 第74回日本酸化ストレス学会一般演題・優秀口演賞 CNDP2はグルタチオン由来のCys-Glyを分解することでCysの再利用を促進しフェロトーシスからの防御に働く
2016/08 - 第74回日本酸化ストレス学会第学術集会優秀ポスター賞肝臓へのシステイン供給におけるxCTとTranssulfuration経路の役割

Association Membership(s) (3)：

日本酸化ストレス学会 , 日本分子生物学会 , 日本生化学会

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