Kasuya Go

Affiliation and department：
Homepage URL (1)： https://scholar.google.co.jp/citations?user=ZKiWyWgAAAAJ&hl=ja&oi=sra

Research field (4)： Clinical pharmacy , Physiology , Biophysics , Structural biochemistry

Research keywords (4)： Electrophysiology , Structural biology , Electron micriscope , Ion channels

Research theme for competitive and other funds (7)：

2023 - 2026 心臓で発現する新規イオンチャネル修飾サブユニットの機能解明とその機能多様性の理解
2023 - 2024 遺伝性不整脈の原因遺伝子KCNQ1とKCNE1が構成するK+チャネル複合体の形成機構の解明
2022 - 2023 n.d.
2020 - 2023 Elucidating the molecular mechanism of voltage-gated K+ channel KCNQ2 involved in the neuronal excitability and epilepsy
2022 - 2023 上皮細胞のK + リサイクルを制御するK+チャネル複合体の機能解析

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Papers (15)：

Daichi Yamanouchi, Go Kasuya, Koichi Nakajo, Yoshiaki Kise, Osamu Nureki. Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex. Molecular Cell. 2023
Go Kasuya, Koichi Nakajo. Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex. eLife. 2022
Jiaying Liu, Go Kasuya, Buntaro Zempo, Koichi Nakajo. Two HCN4 Channels Play Functional Roles in the Zebrafish Heart. Frontiers in Physiology. 2022. 13
Tatsuya Hagino, Takafumi Kato, Go Kasuya, Kan Kobayashi, Tsukasa Kusakizako, Shin Hamamoto, Tomoaki Sobajima, Yuichiro Fujiwara, Keitaro Yamashita, Hisashi Kawasaki, et al. Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1. Nature Communications. 2022. 13. 1
Yoshiaki Kise, Go Kasuya, Hiroyuki H. Okamoto, Daichi Yamanouchi, Kan Kobayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Koichi Nakajo, Osamu Nureki. Structural basis of gating modulation of Kv4 channel complexes. Nature. 2021. 599. 7883. 158-164

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MISC (4)：

Koichi Nakajo, Go Kasuya. Modulation of potassium channels by transmembrane auxiliary subunits via voltage-sensing domains. Physiological Reports. 2024. 12. 6
Go Kasuya, Osamu Nureki. Recent Advances in the Structural Biology of the Volume-Regulated Anion Channel LRRC8. Frontiers in Pharmacology. 2022. 13
Yuichiro Fujiwara, Go Kasuya, Motoyuki Hattori, Osamu Nureki. Structural insights into divalent cation modulations and ligand specificity of ATP-gated P2X receptor channels. Journal of Physiological Sciences. 2016. 66. Supplement1. S66
Tomohiro Nishizawa, Satomi Kita, Andres Maturana, Noritaka Furuya, Kunio Hirata, Go Kasuya, Satoshi Ogawsawara, Naoshi Dohmae, Takahiro Iwamoto, Ryuichiro Ishitani, et al. 1P034 Structural Basis for the Counter-Transport Mechanism of a H+/Ca2+ Exchanger(01B. Protein:Structure; Function,Poster). Seibutsu Butsuri. 2013. 53. supplement1-2. S111-S111

Lectures and oral presentations (5)：

Molecular identification of a new auxiliary subunit for the voltage-gated K+ channel KCNQ1 expressed in hearts
(2024)
Proper interaction between the S1 segment of KCNQ1 and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 K+ channel complex.
(2023)
The proper distance between the S1 segment and KCNE3 is crucial for the constitutively open nature of the KCNQ1-KCNE3 K+ channel.
(2022)
容積感受性陰イオンチャネル LRRC8 のクライオ電子顕微鏡法による構造解析
(第97回日本生理学会大会 (誌上開催) 2020)
クライオ電子顕微鏡を用いた浸透圧感受チャネルの構造解析
(大阪大学蛋白質研究所セミナー「構造情報に基づいた膜イオン輸送タンパク質の生理機能の解明に向けて」 2018)

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