Kitao Hiroyuki

2017 - 2020 Molecular mechanisms of cytokinesis completion and cell fate decision after cytokinesis failure

2015 - 2020 Development of Innovative Treatment Targeting the Sphere Formation Mechanism Involving Cancer Stem Cells

2016 - 2019 Elucidation of molecular mechanisms of and development of combined therapy with immune checkpoint inhibitors for digestive tract cancer

2014 - 2017 Gemonic alteration, molecular subtypes and drug sensitivity in breast cancer

2014 - 2017 Investigation of chemoradiation sensitivity based on the DNA repair mechanism in esophageal carcinoma

2013 - 2016 Novel molecular targeting strategy against chromosomal maintenance factor FANCJ

2013 - 2016 Chromosomal dynamics and development of novel therapy in gastrointestinal tract cancer

2013 - 2016 Establishment of the new therapy based on inflammatory mediator and DNA methylation in colorectal cancer

2013 - 2016 The analysis of the spindle checkpoint protens and the application to the new molecular targetted therapy for colorectal cancer.

2012 - 2016 DNA mismatch repair gene analysis predicts the response to anticancer drug sensitivity in gastrointestinal cancers for tailored therapy.

2011 - 2013 Molecular mechanisms of hormone sensitivity of hormone receptor-positive breast cancer and their application for individual treatment

2011 - 2013 A systematic study of the disorders in the spindle assembly checkpoint genes in colorectal cancer and its application to molecular targeted therapy

2009 - 2011 Genomic instability in the absence of FANCJ and its possible contribution to tumorigenesis

2005 - 2009 Functional analysis of Fanconi anemia genes that are involved in chromosomal stability and tumor prevention

2007 - 2008 Regulation of the ubiquitin system by checkpoint kinases in response to stalled replication forks

2007 - 2008 Molecular mechanism of large genome deletion induced byDisrupting BRCA1-related gene, FA-J.

2005 - 2006 Induction of single DNA double strand break in animal cell genome and its monitoring methodology

2005 - 2006 ファンコニ貧血遺伝子FA-D2と家族性乳ガン遺伝子Brca2との相互作用の再検討

2003 - 2004 Physical monitoring of repair process of chromosomal double stand break induced by simultaneous nuclear introduction of I-SceI endonuclease

2000 - 2004 Functional analysis of genes involved in maintenance of chromosome stability and homologous recombination