2015 - 2017 Critical mechanisms for the determination of hepatocytic and bile ductular differentiation
2014 - 2017 Roles and mechanisms of JNK pathway in liver regeneration and tumor formation
2012 - 2016 Mutual plasticity between hepatocytes and bile ductular cells in ductular reaction - its significance and therapeutic implications
2010 - 2012 プリンヌクレオチド合成経路によるがん幹細胞の未分化維持機構の解明
2005 - 2007 ネクチン-アファディン系による細胞間接着の形成と破壊の分子機構
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Papers (30)：
Junki Fukuda, Shinya Kosuge, Yusuke Satoh, Sho Sekiya, Ryodai Yamamura, Takako Ooshio, Taiga Hirata, Reo Sato, Kanako C. Hatanaka, Tomoko Mitsuhashi, et al. Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinoma. Cancer Science. 2024
Sho Sekiya, Junki Fukuda, Ryodai Yamamura, Takako Ooshio, Yusuke Satoh, Shinya Kosuge, Reo Sato, Kanako C. Hatanaka, Yutaka Hatanaka, Tomoko Mitsuhashi, et al. Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma. Cancer Research. 2023. OF1-OF12
Nishikawa Y, Matsuo Y, Watanabe R, Miyazato M, Matsuo M, Nagahama Y, Tanaka H, Ooshio T, Goto M, Okada Y, et al. Hepatocyte-specific damage in acute toxicity of sodium ferrous citrate: Presentation of a human autopsy case and experimental results in mice. Toxocol Rep. 2023. 10. 669-679
Masanori Goto, Takako Ooshio, Masahiro Yamamoto, Hiroki Tanaka, Yumiko Fujii, Lingtong Meng, Yuki Kamikokura, Yoko Okada, Yuji Nishikawa. High levels of Myc expression are required for the robust proliferation of hepatocytes, but not for the sustained weak proliferation. Biochimica et biophysica acta. Molecular basis of disease. 2023. 1869. 4. 166644-166644
Yang Liu, Bing Xin, Masahiro Yamamoto, Masanori Goto, Takako Ooshio, Yuki Kamikokura, Hiroki Tanaka, Lingtong Meng, Yoko Okada, Yusuke Mizukami, et al. Generation of combined hepatocellular-cholangiocarcinoma through transdifferentiation and dedifferentiation in p53-knockout mice. Cancer science. 2021. 112. 8. 3111-3124
Takako Ooshio, Masahiro Yamamoto, Kiyonaga Fujii, Bing Xin, Kenji Watanabe, Masanori Goto, Yoko Okada, Akira Suzuki, Josef M. Penninger, Hiroshi Nishina, et al. Hepatocyte MKK7 Contributes to Restoration of the Liver Parenchyma Following Injury. 2020
Masanori Goto, Takako Ooshio, Kiyonaga Fujii, Masahiro Yamamoto, Kenji Watanabe, Bing Xin, Yoko Okada, Yuji Nishikawa. Myc is involved in DNA synthesis, but not in glycometabolic changes of cultured mouse hepatocytes. CANCER SCIENCE. 2018. 109. 456-456
Identifying RFK and MEK as potential therapeutic targets for pancreatic cancer through a Drosophila screening
(6th Edition of International Cancer Conference 2023)
Identifying a novel therapeutic candidate for pancreatic cancer using a Drosophila model
(Serendipity Workshop 2022 2022)
