Kiwaki Takumi

キワキタクミ | Kiwaki Takumi

Affiliation and department：
Job title： Assistant Professor

Research field (3)： Experimental pathology , Tumor biology , Human pathology

Research theme for competitive and other funds (4)：

2023 - 2026 がん細胞の HGF 活性制御分子に着目した HGF-MET 依存性転移機構の解明
2020 - 2023 Investigation of activation mechanisms and exploration of inhibition therapy of HGF-MET signal in cancer microenvironment
2019 - 2020 ヒト固形がんにおける Patient derived xenograft (PDX) 株の樹立と,それを用いた HGF-MET シグナル標的治療の開発
がんの転移と細胞接着分子 L1CAM 発現との関連についての臨床病理学的検討

Papers (23)：

Takashi Ueno, Takumi Kiwaki, Hironori Betsunoh, Kaoru Ito, Takaya Murashima, Masato Fujii, Takahiro Nagai, Shoichiro Mukai, Atsuro Sawada, Toshiyuki Kamoto. Metastasis of malignant melanoma to urinary tract: a case report. Journal of medical case reports. 2024. 18. 1. 396-396
Chihiro Kawasoe, Yoshi Miyamoto, Kaoru Ito, Takaya Murashima, Takahiro Nagai, Hiroki Takamori, Takumi Kiwaki, Toshio Kamimura, Shoichiro Mukai, Toshiyuki Kamoto. Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report. Research and Reports in Urology. 2023
Makiko Kawaguchi, Hiroaki Kataoka, Takumi Kiwaki, Liang Weiting, Sayaka Nagata, Kazuo Kitamura, Tsuyoshi Fukushima. Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin-4 expression in the colonic epithelium. FEBS open bio. 2023
Fujii M, Akioka T, Kimura S, Nagai T, Kiwaki T, Fukushima T, Mukai S, Kamoto T. Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice. Human cell. 2023. 36. 2. 775-785
帖佐宣昭, 津守伸一郎, 蜂須賀裕志, 木脇拓道, 緒方克己. PR3-ANCA陽性の頭皮に限局した肉芽腫性血管炎による皮膚潰瘍頭皮に生じた皮膚限局性多発血管炎性肉芽腫症か?. 西日本皮膚科. 2022. 84. 6. 512-516

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MISC (20)：

川口真紀子, 木脇拓道, 福島剛. HAI-1機能不全はケラチノサイトのMMP-9発現を誘導する(Insufficiency of HAI-1 upregulates MMP-9 expression and induces degradation of epidermal basement membrane). 日本癌学会総会記事. 2023. 82回. 1341-1341
木脇拓道, 川口真紀子, 片岡寛章, 福島剛. LRP11は肺腺癌の予後不良と関連する(Low-density lipoprotein receptor related protein 11(LRP11) contributes to poor prognosis in lung adenocarcinoma). 日本癌学会総会記事. 2023. 82回. 1397-1397
福島剛, 齋藤清貴, 堀之内翔一, 川口真紀子, 木脇拓道. 全身転移をきたした脳腫瘍の一剖検例. 日本病理学会会誌. 2023. 112. 1. 315-315
梅北佳子, 木脇拓道, 山本晃士, 田中弘之, 池ノ上実, 武野慎祐, 片岡寛章. 食道扁平上皮癌における細胞膜上HAI-1の発現と予後に関する免疫組織化学的検討. 日本病理学会会誌. 2023. 112. 1. 353-353
川口真紀子, 木脇拓道, 福島剛, 片岡寛章. マトリプターゼ欠損は大腸発癌を誘発し、Claudin-7の局在異常をもたらす(Loss of matriptase leads to colorectal carcinogenesis and causes abnormal localization of Claudin-7 in tumor cells). 日本癌学会総会記事. 2022. 81回. P-2088

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Lectures and oral presentations (3)：

Exploration of a novel anti-cancer therapy using patient-derived cancer organoids
(2021)
ヒト HGF 導入 SCID マウスを用いた HGF-MET シグナル解析と阻害治療の開発
(第38回日本ヒト細胞学会学術集会 2020)
A synthetic small molecule inhibitor of pro-HGF activation, ZFH7116, suppresses the growth of SAS squamous cell carcinoma line in human HGF knock-in SCID mice: A pilot study
(ASBMB Symposia: Serine Proteases in Pericellular Proteolysis and Signaling 2019)

Education (1)：

Professional career (1)：

Work history (6)：

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Awards (2)：

2024/08 - 日本ヒト細胞学会優秀研究奨励賞
2020/05 - The Kyushu-Okinawa Branch of the Japanese Society of Pathology Young Pathologist Encouragement Award

Association Membership(s) (5)：

日本リンパ腫学会 , 日本ヒト細胞学会 , 日本臨床細胞学会 , 日本癌学会 , 日本病理学会

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