Rchr
J-GLOBAL ID：201901006027076622   Update date: May. 01, 2024

Sato Hiromi

Sato Hiromi
Affiliation and department：
Chiba University Lab of Clinical Pharmacology & Pharmacometrics, Graduate School of Pharmaceutical Sciences

About Chiba University Lab of Clinical Pharmacology & Pharmacometrics, Graduate School of Pharmaceutical Sciences


Job title： Associate professor
Research field  (2)： Pharmacology ,  Clinical pharmacy
Research keywords  (17)： cancer drug resistance ,  brain cancer ,  tumor microenvironment ,  astrocyte ,  metabolic flux analysis ,  connexin ,  gap junction ,  metabolome ,  sex differences ,  aging ,  drug-drug interaction ,  modeling and simulation ,  MBMA ,  diabetes mellitus ,  CVR ,  adipose inflammation ,  drug absorption
Research theme for competitive and other funds  (14)：
  • 2021 - 2024 Significance of ketone body metabolic shift in diabetes and long-term prognosis prediction
  • 2019 - 2022 薬物相互作用・生理機能変化を踏まえた医薬品の投与最適化の評価・予測手法の開発
  • 2019 - 2021 cGAS-STING 経路のがん進展への関与および治療標的の可能性
  • 2017 - 2020 Model based meta-analysis and establishment of PBPK model for appropriate use of factor Xa inhibitor
  • 2015 - 2019 Expression of precipitating factors of pruritus found in humans in an imiquimodinduced psoriasis mouse model
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Papers (95)：
  • Sato H, Marutani R, Takaoka R, Mori-Fegan D, Wang X, Maeda K, Kusuhara H, Suzuki H, Yoshioka H, Hisaka A. Model-based meta-analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism. CPT: Pharmacometrics & Systems Pharmacology. 2023. 12. 8. 1132-1142
  • Hozuki S, Yoshioka H, Asano S, Nakamura M, Koh S, Shibata Y, Tamemoto Y, Sato H, Hisaka A. Integrated use of in vitro and in vivo information for comprehensive prediction of drug interactions due to inhibition of multiple CYP isoenzymes. Clinical Pharmacokinetics. 2023
  • Tamemoto Y, Shibata Y, Hashimoto N, Sato H, Hisaka A. Involvement of multiple cytochrome P450 isoenzymes in drug interactions between ritonavir and direct oral anticoagulants. Drug Metabolism and Pharmacokinetics. 2023. 53. 100498-100498
  • Yoshitomo A, Asano S, Hozuki S, Tamemoto Y, Shibata Y, Hashimoto N, Takahashi K, Sasaki Y, Ozawa N, Kageyama M, et al. Significance of basal membrane permeability of epithelial cells in predicting intestinal drug absorption. Drug Metabolism and Disposition. 2023. 51. 3. 318-328
  • Kuretake Soejima, Hiromi Sato, Akihiro Hisaka. Age-Related Change in Hepatic Clearance Inferred from Multiple Population Pharmacokinetic Studies: Comparison with Renal Clearance and Their Associations with Organ Weight and Blood Flow. Clinical pharmacokinetics. 2022. 61. 2. 295-305
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MISC (60)：
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Books (3)：
  • 性差医学・医療の進歩と臨床展開Vol.9:薬物動態と薬力学における性差
    医学のあゆみ 2018
  • 薬物代謝の違いを考慮した処方とは? -男女で効果に違いはあるか?-
    ハートレビュー,メディカルレビュー社 2014
  • Chapter 10: Connexin 43 Enhances the Cisplatin-Induced Cytotoxicity in Mesothelioma Cells
    2012
Lectures and oral presentations  (192)：
  • Systematic Prediction of Drug Interactions Integrating In Vivo and In Vitro Information Considering Contributions by Multiple Molecular Species of CYP and Transporter
    (2020)
  • メタボローム特性とがん薬物抵抗性の連関
    (第34回日本薬物動態学会年会 2019)
  • Simultaneous In Vitro Evaluation of Efflux by P-glycoprotein and Metabolism by CYP3A Using CYP3A4-CPR-HAC/Caco-2 Cells
    (第34回日本薬物動態学会年会 2019)
  • Quantitative evaluation of reduced hepatic clearance in elderly people based on meta-analysis of population pharmacokinetic analyses
    (第34回日本薬物動態学会年会 2019)
  • Significance of involvement of multiple molecular species in drug interactions by CYP inhibition.
    (第34回日本薬物動態学会年会 2019)
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Education (3)：
  • 2006 - 2008 Chiba University Graduate School of Pharmaceutical Sciences Ph.D. (Pharmaceutical Sciences)
  • 2004 - 2006 Chiba University Graduate School of Pharmaceutical Sciences Master of Sciences (Medical Pharmacy)
  • 2000 - 2004 Chiba University Faculty of Pharmaceutical Sciences
Professional career (1)：
  • 博士(薬学) (千葉大学)
Work history (4)：
  • 2023/10 - 現在 Chiba University Graduate School of Pharmaceutical Sciences Associate professor
  • 2018/03 - 2023/09 Chiba University Graduate School of Pharmaceutical Sciences Lecturer
  • 2008/04 - 2018/02 Chiba University Graduate School of Pharmaceutical Sciences Assistant professor
  • 2011/04 - 2011/06 The University of British Columbia The Life Sciences Institute(Acceptance: Prof. Christian C. Naus) Visiting scientist
Committee career (9)：
  • 2022/12 - 現在 日本臨床薬理学会 評議員
  • 2022/07 - 現在 日本毒性学会 評議員
  • 2022/03 - 現在 日本性差医学・医療学会 評議員
  • 2013 - 現在 日本薬学会 薬理系薬学部会 若手世話人
  • 2012 - 現在 日本薬理学会 学術評議員
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Awards (6)：
  • 2022/10 - DMPK award 1st place
  • 2022/03 - 日本薬学会 令和3年度日本薬学会 薬理系薬学部会奨励賞 がん治療抵抗性におけるgap junctionの関与
  • 2019/06 - 12th Research Award of Japan Reserch Foundation Clinical Pharmacology
  • 2017/01 - 日本性差医学・医療学会 第10回日本性差医学・医療学会 優秀ポスター賞 NBDレセプト情報オープンデータにみる薬剤提供実態の男女差
  • 2015/03 - 千葉東洋医学シンポジウム 第40回千葉東洋医学シンポジウム 優秀発表賞 更年期障害患者における桂枝茯苓丸治療効果に関するエストロゲン受容体遺伝子多型の関与
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Association Membership(s) (8)：
THE JAPANESE SOCIETY OF TOXICOLOGY ,  American Association for Cancer Research ,  日本性差医学・医療学会 ,  THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS ,  THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS ,  THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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