Takashi Yahata

ヤハタタカシ | Takashi Yahata

Affiliation and department：
Job title： Professor

Research field (3)： Immunology , Tumor biology , Hematology and oncology

Research theme for competitive and other funds (18)：

2021 - 2025 線溶系制御因子を標的とした新規複合的がん免疫療法の確立
2020 - 2022 Development of novel genome editing tool for gene therapy and its application to cancer therapy
2018 - 2021 An analysis for development of myelodysplastic syndrome and influence of ROS
2017 - 2021 Analysis of interraction of multiple myeloma cells and bone marrow stroma cells using xenograft models
2016 - 2018 The exploration of new drug for the treatment of Notch-active tumor cells.

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Papers (62)：

Kaito Harada, Takashi Yahata, Makoto Onizuka, Takamasa Ishii, Abd Aziz Ibrahim, Eri Kikkawa, Yoichi Gondo, Kiyoshi Ando. Mitochondrial Electron Transport Chain Complex II Dysfunction Causes Premature Aging of Hematopoietic Stem Cells. Stem cells (Dayton, Ohio). 2023. 41. 1. 39-49
Shohei Kawakami, Mitsuyo Tsuma-Kaneko, Masakazu Sawanobori, Tomoko Uno, Yoshihiko Nakamura, Hideyuki Matsuzawa, Rikio Suzuki, Makoto Onizuka, Takashi Yahata, Kazuhito Naka, et al. Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells. Scientific reports. 2022. 12. 1. 704-704
Ken-Ichi Hirano, Hiroyuki Hosokawa, Takashi Yahata, Kiyoshi Ando, Masayuki Tanaka, Jin Imai, Masaki Yazawa, Masato Ohtsuka, Naoko Negishi, Sonoko Habu, et al. Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium. Frontiers in immunology. 2022. 13. 852427-852427
Ken-Ichi Hirano, Hiroyuki Hosokawa, Maria Koizumi, Yusuke Endo, Takashi Yahata, Kiyoshi Ando, Katsuto Hozumi. LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice. eLife. 2021. 10
Kaito Harada, Takashi Yahata, Makoto Onizuka, Abd Aziz Ibrahim, Eri Kikkawa, Toshio Miyata, Kiyoshi Ando. Plasminogen activator inhibitor type-1 is a negative regulator of hematopoietic regeneration in the adipocyte-rich bone marrow microenvironment. Biochemical and biophysical research communications. 2021. 557. 180-186

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MISC (6)：

今井仁, 今井仁, 八幡崇, 田中里佳, 金子元基, 水上創, 中原史雄, 市川仁志, 稲垣豊, 稲垣豊, et al. Suppress Intestinal Fibrosis in Crohn’s Disease by Fibrinolytic System Adjustment. 潰瘍. 2020. 47. 91-96
片平泰弘, 樋口廣士, 山本雄一郎, 安藤潔, 幸谷愛, 松下弘道, 八幡崇, 小池亮, 佐藤克明, 今留謙一, et al. Increased Granulopoiesis in the Bone Marrow following Epstein-Barr Virus Infection(和訳中). 東京医科大学雑誌. 2020. 78. 3. 290-291
Daisuke Harama, Minori Tamai, Takeshi Inukai, Kumiko Goi, Takashi Yahata, Kiyoshi Ando, Takumi Ito, Hiroshi Handa, Kanji Sugita. Lenalidomide Effectively Induces Philadelphia-Chromosome Positive ALL Cells into Apoptosis in Synergy with Tyrosine Kinase Inhibitor. BLOOD. 2016. 128. 22
Natsuko Yamakawa, Ken-Ichi Imadome, Takashi Yahata, Ai Kotani. MODULATION OF MACROPHAGES BY TUMOR-DERIVED SECRETARY SMALL RNAS IS CRITICAL FOR EBV POSITIVE LYMPHOMA FORMATION. EXPERIMENTAL HEMATOLOGY. 2015. 43. 9. S102-S102
Hiromichi Matsushita, Takashi Yahata, Yin Sheng, Yoshihiko Nakamura, Yukari Muguruma, Hideyuki Matsuzawa, Masayuki Tanaka, Hideki Hayashi, Tadayuki Sato, Anar Damdinsuren, et al. In Vivo Analysis of PML-RARA in a Humanized Mouse Model. BLOOD. 2014. 124. 21

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Patents (2)：

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