SATO TOSHIHIRO

サトウトシヒロ | SATO TOSHIHIRO

Affiliation and department：
Job title： Assistant Professor

Research field (4)： Clinical pharmacy , Clinical pharmacy , Clinical pharmacy , Food sciences

Research keywords (12)： Clinical Pharmacy , Drug interaction , Transporter , Organic Anion Transporting Polypeptide (OATP) , CryoEM , Treatment-resistant schizophrenia , Clozapine , Renal failure , Uremic toxins , Liver injury , Bile acids , Flavonoids

Research theme for competitive and other funds (12)：

2024 - 2027 Comprehensive analysis of functional lipids aimed at searching for accurate prognostic biomarkers of non-alcoholic steatohepatitis
2022 - 2025 Identification and evaluation of novel biomarkers by metabolome analysis for drug interaction on renal drug transporters
2023 - 2024 Search of metabolomic and pharmacogenomic biomarkers for a novel diagnosis and treatment method based on stratification analysis of the patients with treatment-resistant schizophrenia
2022 - 2024 Development of a simultaneous quantitation method for antidepressant in human plasma and treatment method based on pharmacometric analysis of the patients with treatment-resistant schizophrenia
2021 - 2024 Elucidation of the molecular mechanism and pathophysiology of Niemann-Pick disease type C by a multifaceted approach

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Papers (41)：

Masahiro WATANABE, Masamitsu MAEKAWA, Toshihiro SATO, Yu SATO, Masaki KUMONDAI, Masafumi KIKUCHI, Nariyasu MANO. Fundamental Investigation of Signal Drift in Continuous Liquid Chromatography/High Resolution Mass Spectrometric Plasma Analysis Toward Global Metabolomics. CHROMATOGRAPHY. 2024
Masahiro Watanabe, Masamitsu Maekawa, Keitaro Miyoshi, Toshihiro Sato, Yu Sato, Masaki Kumondai, Masayoshi Fukasawa, Nariyasu Mano. Global and Targeted Metabolomics for Revealing Metabolomic Alteration in Niemann-Pick Disease Type C Model Cells. Metabolites. 2024. 14. 10. 515-515
Minami Yamauchi, Masamitsu Maekawa, Toshihiro Sato, Yu Sato, Masaki Kumondai, Mio Tsuruoka, Jun Inoue, Atsushi Masamune, Nariyasu Mano. Liquid Chromatography/Tandem Mass Spectrometry-Based Simultaneous Analysis of 32 Bile Acids in Plasma and Conventional Biomarker-Integrated Diagnostic Screening Model Development for Hepatocellular Carcinoma. Metabolites. 2024. 14. 9. 513-513
Yu Sato, Hiroki Kondo, Yuji Sato, Ai Abe, Masafumi Kikuchi, Toshihiro Sato, Masaki Kumondai, Kohei Yoshikawa, Yoshihiro Hayakawa, Masamitsu Maekawa, et al. Development of Simultaneous Drug Concentration Measurement Method Using an Automated Pretreatment Liquid Chromatography/Tandem Mass Spectrometry System for Therapeutic Drug Monitoring. Pharmaceutics. 2024. 16. 9. 1138-1138
Masamitsu Maekawa, Anna Iwahori, Masaki Kumondai, Yu Sato, Toshihiro Sato, Nariyasu Mano. Determination of Choline-Containing Compounds in Rice Bran Fermented with Aspergillus oryzae Using Liquid Chromatography/Tandem Mass Spectrometry. Mass Spectrometry. 2024. 13. 1. A0151-A0151

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MISC (21)：

佐藤紀宏, 公文代將希, 林和未, 小野口豪, 小松浩, 平塚真弘, 平塚真弘, 前川正充, 前川正充, 富田博秋, et al. クロザピンの血中濃度変動における有機アニオン輸送ポリペプチドの関与. 臨床化学(Web). 2024. 53
前川正充, 前川正充, 佐藤紀宏, 雨山智, 佐藤稔之, 佐藤祐司, 前川麻央, 五十嵐敏明, 松浦正樹, 菊地正史, et al. 東北大学病院薬剤部における情報通信技術の導入と職員ならびに業務に与える影響の調査. 医療薬学フォーラム講演要旨集. 2023. 31st
菊地正史, 菊地正史, 齊藤明博, 佐藤祐司, 公文代將希, 佐藤裕, 佐藤紀宏, 二宮匡史, 井上淳, 前川正充, et al. マイクロサンプリングデバイスを用いたヒト血漿中レンバチニブ濃度定量法の開発. 医療薬学フォーラム講演要旨集. 2023. 31st
大竹彩奈, 佐藤紀宏, 近藤宏輝, 大久保美祐, 臼井拓也, 佐藤祐司, 前川正充, 眞野成康. シスプラチン治療における急性腎障害の診断に関する現状分析. 日本腎臓病薬物療法学会誌. 2023. 12
阿部愛, 前川正充, 佐藤紀宏, 佐藤裕, 公文代將希, 高橋勇人, 菊地正史, 檜垣克美, 小倉次郎, 眞野成康. LC/MS/MSを用いるニーマンピック病C型モデル細胞におけるステロイドホルモンの代謝変動解析. JSBMS Letters. 2022. 47. Suppl. 110-110

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Books (1)：

肝疾患時の腎排泄型薬物の投与設計最適化を目指した胆汁酸-腎薬物トランスポーター相互作用研究
(公財)政策医療振興財団 2023

Lectures and oral presentations (58)：

Involvement of organic anion transporting polypeptide on the alteration of clozapine plasma concentration.
(The 64th Annual Meeting of the Japanese Society of Clinical Chemistry 2024)
Genomic analysis of drug metabolizing enzymes and transporters to clarify the inter- & intra-individual alteration of clozapine plasma concentration
(The 40th Annual Meeting for The Japanese Society of Therapeutic Drug Monitoring 2024)
Evaluation of a 4 year-training programs for newcomers in the Department of Pharmaceutical Sciences in Tohoku University Hospital
(The 13rd Annual Meeting of Japanese Society of Hospital Pharmacists in Tohoku Branch 2024)
LC/MS/MS analysis of plasma bile acids in patients with liver diseases for development of hepatocellular carcinoma biomarkers
(The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024)
Analysis of bile acid-drug interaction on organic anion transporting polypeptide 2B1
(The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024)

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Professional career (1)：

Ph.D., Pharmaceutical Science (Tohoku University)

Awards (2)：

2024/03 - Pharmaceutical Society of Japan Students' Excellent Presentation Award in The 144th Annual Meeting of the Pharmaceutical Society of Japan Analysis of bile acid-drug interaction on organic anion transporting polypeptide 2B1
2023/03 - Pharmaceutical Society of Japan Students' Excellent Presentation Award in The 143rd Annual Meeting of the Pharmaceutical Society of Japan Fundamental analysis of the involvement of bile acids in the regulation of renal drug transporter OATP4C1 expression.

Association Membership(s) (8)：

The Japanese Society of Therapeutic Drug Monitoring , Society of Bile Acid Research , The Society of Drug Interaction Research , The Japanese Society of Clinical Pharmacology and Therapeutics , JAPAN SOCIETY OF CLINICAL CHEMISTRY , THE PHARMACEUTICAL SOCIETY OF JAPAN , Japanese Society of Hospital Pharmacists , JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES

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