Hattori Yorito

ハットリヨリト | Hattori Yorito

Affiliation and department：
Job title： Director
Other affiliations (1)：

National Cerebral and Cardiovascular Center Department of Neurology Deputy Director

Research field (3)： Neuropathology , Neuropathology , Neurology

Research keywords (16)：腸内細菌 , RNF213 , APOE4 , SIRT1 , Vascular dementia , Cerebral infarction , Small vessel disease , 15O-gas PET , Carotid stenosis , Amyloid β , Alzheimer's disease , Geriatrics , Neurology , Stroke , VCI: vascular cognitive impairment , Dementia

Research theme for competitive and other funds (20)：

2023 - 2026 NAD+/SIRT1軸に着目した脳血管を標的とした血管性認知障害の治療法開発
2023 - 2024 腸内細菌叢によるエクオール産生に着目した脳卒中発症予防機構の解明
2021 - 2024 コラーゲン結合蛋白産生性齲蝕原性細菌の脳微小出血発症機序と革新的治療法開発
2022 - 2023 血管内皮を標的とした革新的脳卒中治療法の探索
2022 - 2022 Brain-gut axisに着目した腸内細菌叢異常に伴う脳卒中発症メカニズムの解明と新規治療法の開発

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Papers (57)：

Yorito Hattori, Yoshinori Kakino, Eri Kiyoshige, Soshiro Ogata, Kunihiro Nishimura, Hidehiro Iida, Masafumi Ihara. Blood Midregional Proadrenomedullin as a Hemodynamic Severity Marker in Asymptomatic Carotid Artery Stenosis/Occlusion. Stroke. 2024
Cesario Borlongan, Elga Esposito, Laarni Grace Corales, Yorito Hattori, Yu Hayashi, Masafumi Ihara, Jeffrey J. Iliff, Kassandra Kisler, Shinobu Kitazume, Schuichi Koizumi, et al. From bench to bedside: US-Japan Collaborative Workshop on the NVU. The Journal of Physiological Sciences. 2024. 74. S1
Shuhei Egashira, Tomotaka Tanaka, Takayuki Yamashiro, Satoshi Saito, Soichiro Abe, Takeshi Yoshimoto, Kazuki Fukuma, Hiroyuki Ishiyama, Eriko Yamaguchi, Yorito Hattori, et al. High pillow and spontaneous vertebral artery dissection: A case-control study implicating “Shogun pillow syndrome”. European Stroke Journal. 2024. 23969873231226029-23969873231226029
Yorito Hattori, Yoshinori Kakino, Yuji Hattori, Mari Iwashita, Hitoshi Uchiyama, Kotaro Noda, Takeshi Yoshimoto, Hidehiro Iida, Masafumi Ihara. Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion. Journal of stroke. 2024. 26. 1. 64-74
Satoshi Saito, Keisuke Suzuki, Ryo Ohtani, Takakuni Maki, Hisatomo Kowa, Hisatsugu Tachibana, Kazuo Washida, Nobuya Kawabata, Toshiki Mizuno, Rie Kanki, et al. Efficacy and Safety of Cilostazol in Mild Cognitive Impairment: A Randomized Clinical Trial. JAMA network open. 2023. 6. 12. e2344938

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MISC (146)：

猪原匡史, 殿村修一, 服部頼都, 中岡良和. 「Microbiomeと脳」脳卒中における脳-口-腸相関. 脳循環代謝. 2023. 35. 1. 48-48
柿野圭紀, 服部頼都, 飯田秀博, 猪原匡史. 無症候性頸動脈狭窄/閉塞症における認知機能と脳循環代謝へのAPOE4の影響. 脳循環代謝. 2023. 35. 1. 74-74
植川顕, 服部頼都, Park Laibaik, Iadecola Costantino, 武笠晃丈. 脳境界マクロファージは脳血管周囲でCD36を介して酸化ストレスを産生し脳アミロイド血管症を悪化させる. 脳循環代謝. 2023. 35. 1. 77-77
村田博朗, 服部頼都, 堀美香, 野田浩太郎, 長井篤, 山口修平, 斯波真理子, 猪原匡史. 家族性高コレステロール血症と脳微小出血との関連についての検討. 脳循環代謝. 2023. 35. 1. 89-89
猪原匡史, 殿村修一, 服部頼都, 中岡良和. 「Microbiomeと脳」脳卒中における脳-口-腸相関. 脳循環代謝. 2023. 35. 1. 48-48

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Books (5)：

脳卒中治療Controversy
中外医学社 2023
Anticoagulant therapies for prevention of ischemic stroke
2022
第3節アメロイドコンストリクターを用いた慢性血管狭窄モデル
疾患モデルの作成と利用-循環器疾患 2021
脳卒中-新時代の治療を求めて「SIRT1」.
日本臨牀特集:脳卒中 II. 進歩する基礎研究 2016
シナプス内,シナプス外NMDA受容体のGluN2A,GluN2Bサブユニットは神経毒性に関与する.
分子脳血管病 2014

Lectures and oral presentations (18)：

齲蝕原生細菌と血管性認知症との関連と新規治療法開発
(2024)
頸動脈狭窄/閉塞症におけるAPOE4の影響
(2024)
NAD+/SIRT1経路の活性化を介した頸動脈狭窄症の新規治療法開発
(2024)
頸動脈狭窄症における脳循環代謝低下、認知機能障害のバイオマーカー探索
(STROKE 2024 2024)
脳梗塞発症と血小板数の概日リズムとの関連
(STROKE 2024 2024)

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Education (2)：

PhD, Kyoto University Graduate School of Medicine
MD, Kansai Medical University

Work history (2)：

2024/04 - 現在 National Cerebral and Cardiovascular Center Department of Preemptive Medicine for Dementia Director
2019/04 - 現在 National Cerebral and Cardiovascular Center Department of Neurology Deputy Director

Awards (10)：

2024/04 - The American College of Cardiology Young Author Achievement Award as Mentor
2020 - Japan Society for Dementia Research The Award of Japan Society for Dementia Research
2019 - Vas-Cog J 2019 First Prize
2019 - American Heart Association, International Stroke Conference Vascular Cognitive Impairment Award
2017 - Japan Society for the Promotion of Science JSPS Overseas Research Fellowships (2017-2018)

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Association Membership(s) (14)：

日本神経学会脳神経内科指導医 , 日本老年医学会老年科指導医 , 日本脳卒中学会脳卒中指導医 , Society for Neuroscience , International Society of Cerebral Blood Flow and Metabolism , American Heart Association , 日本脳循環代謝学会 , 日本認知症学会認知症指導医 , Board Certified Dementia Specialist of the Japan Society for Dementia Research , Board Certified Stroke Specialist of the Japan Stroke Society , Board Certified Geriatrician of the Japan Geriatrics Society , Board Certified Neurologist of the Japanese Society of Neurology , Fellow of the Japanese Society of Internal Medicine , Board Certified Member of the Japanese Society of Internal Medicine

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