Rchr
J-GLOBAL ID：201901006870958807   Update date: Jan. 30, 2024

Yokoyama Hideshi

Yokoyama Hideshi
Affiliation and department：
Tokyo University of Science Faculty of Pharmaceutical Sciences, Department of Medicinal and Life Sciences

About Tokyo University of Science Faculty of Pharmaceutical Sciences, Department of Medicinal and Life Sciences


Job title： Associate Professor
Homepage URL  (1)： http://www.rs.tus.ac.jp/yokoyama/index.html
Research field  (1)： Structural biochemistry
Research keywords  (1)： Protein structural biology, X-ray crystallography
Research theme for competitive and other funds  (8)：
  • 2022 - 2025 Elucidation of mechanism of inhibition by kinesin motor with structural and thermodynamic analyses and development of anticancer drugs
  • 2019 - 2022 Clarification of the molecular mechanism and establishment of the basis for drug development toward epithelial cancer barrier
  • 2017 - 2020 Elucidation of inhibition mechanism of kinesin motor to develop anti-cancer drugs
  • 2014 - 2017 Structure determination of oligomeric membrane protein involved in forming membrane vesicles and elucidation of the regulation mechanism
  • 2012 - 2015 SBDD targeting metalloenzyme RNA polymeraze of influenza virus
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Papers (48)：
  • Horizumi, Y., Goto, S., Takatsuka, M. & Yokoyama, H. Effects of local anesthetics on liposomal membranes determined by their inhibitory activity of lipid peroxidation. MOLECULAR PHARMACEUTICS. 2023. 20. 6. 2911-2918
  • Yokoyama, H. & Matsui, I. Higher-order structure formation using refined monomer structures of lipid raft markers, Stomatin, Prohibitin, Flotillin, and HflK/C-related proteins. FEBS Open Bio. 2023. 13. 5. 926-937
  • Tsunoda, C., Goto, S., Hiroshige, R., Kasai, T., Okumura, Y. & Yokoyama, H. Optimization of the stability constants of the ternary system of diclofenac/famotidine/β-cyclodextrin by nonlinear least-squares method using theoretical equations. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2023. 638. 122913
  • Shibuya, A., Suzuki, A., Ogo, N., Sawada, J., Asai, A. & Yokoyama, H. Crystal structure of the motor domain of centromere-associated protein E in complex with a non-hydrolysable ATP analogue. FEBS LETTERS. 2023. 597. 8. 1138-1148
  • Kurosawa, Y., Goto, S., Mitsuya, K., Otsuka, Y. & Yokoyama, H. Interaction mode of hydroxypropyl-β-cyclodextrin with vaccine adjuvant components Tween 80 and Triton X-100 revealed by fluorescence increasing-quenching analysi. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2023. 25. 8. 6203-6213
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MISC (26)：
  • 渋谷明日香、鈴木翠、横山英志. キネシンCENP-EとATPアナログの複合体のX線結晶構造解析. Photon Factory Activity Report 2021. 2022. 39. B. 141-141
  • Shibuya, A., Ogo, N., Sawada, J., Asai, A., Yokoyama, H. Structure determination of the motor domain of centromere-associated protein E. Acta Crystallographica A-Foundation and Advances. 2021. 77. C. 709-709
  • 渋谷明日香、横山英志. キネシンCENP-Eの構造解析とその機能の解明. Photon Factory Activity Report 2020. 2021. 38. B. 192-192
  • 渋谷明日香、横山英志. キネシンCENP-Eを用いた結晶化とX線回折データの分解能の改善. Photon Factory Activity Report 2019. 2020. 37. B. 56-56
  • Yokoyama, H. Structure determinations of kinesin spindle protein Eg5 in complex with its inhibitors. Photon Factory Activity Report 2018. 2019. 36. B. 126-126
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Books (7)：
  • 理大 科学フォーラム 「編集後記」
    東京理科大学 2020
  • 理大 科学フォーラム 「つれづれぐさ 時間の使い方」
    東京理科大学 2018
  • FD通信 2018.6Vol.54「薬学部生命創薬科学科「薬品物理化学2」における授業収録配信システム利用例」
    東京理科大学 教育開発センター / FD啓発・広報小委員会 2018
  • 理工系の基礎 薬学
    丸善出版 2018
  • Conscience 2018.3. Vol.119 「クイズで学ぶScience(先生方の研究をクイズ形式で紹介!!)」
    学校法人東京理科大学 広報課 2018
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Lectures and oral presentations  (97)：
  • Crystallization of podocin, associated with nephrotic syndrome
    (26th Congress and General Assembly of the International Union of Crystallography 2023)
  • ネフローゼ症候群原因タンパク質podocinの結晶化
    (日本薬学会 第143年会 2023)
  • キネシンCENP-Eモータードメインと阻害剤複合体の調製と結晶化
    (日本薬学会 第143年会 2023)
  • The combination of polymorphsim and hydrotropes additively contributes to dissolution of indomethacin
    (4th International Symposium on BA/BE of Oral Drug Products 2022)
  • Effect of hydrophobic hydration on the intermolecular interaction between acidic and bacic drugs: Diffusion coefficient of Fick's law determined by diffusion ordered spectroscopy and electrochemical impedance spectroscopy.
    (4th International Symposium on BA/BE of Oral Drug Products, 2022 2022)
ｍore...
Education (2)：
  • - 2002 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • - 1997 The University of Tokyo Faculty of Pharmaceutical Sciences
Committee career (1)：
  • 2018/04 - 2020/03 日本薬学会 物理系薬学部会 関東ブロック世話人
Awards (1)：
  • 2009/07/11 - 膜タンパク質ストマチンの三次元構造
Association Membership(s) (1)：
日本薬学会 物理系薬学部会
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