Yokoyama Hideshi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.rs.tus.ac.jp/yokoyama/index.html

Research field (1)： Structural biochemistry

Research keywords (1)： Protein structural biology, X-ray crystallography

Research theme for competitive and other funds (8)：

2022 - 2025 Elucidation of mechanism of inhibition by kinesin motor with structural and thermodynamic analyses and development of anticancer drugs
2019 - 2022 Clarification of the molecular mechanism and establishment of the basis for drug development toward epithelial cancer barrier
2017 - 2020 Elucidation of inhibition mechanism of kinesin motor to develop anti-cancer drugs
2014 - 2017 Structure determination of oligomeric membrane protein involved in forming membrane vesicles and elucidation of the regulation mechanism
2012 - 2015 SBDD targeting metalloenzyme RNA polymeraze of influenza virus

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Papers (53)：

Oshite, Y., Wada-Hirai, A., Ichii, R., Kuroda, C., Hasegawa, K., Hiroshige, R., Yokoyama, H., Tsuchida, T. & Goto, S. Comparative study on the effects of the inclusion complexes of non-steroidal anti-inflammatory drugs with 2-hydroxypropyl-β-cyclodextrins on dissociation rates and supersaturation. RSC Pharmaceutics. 2024. 1. 80-97
Hasegawa, K., Goto, S., Kataoka, H., Chatani, H., Kinoshita, T., Yokoyama, H.. & Tsuchida, T. Quantification of crystallinity during indomethacin crystalline transformation from α- to γ-polymorphic forms and of the thermodynamic contribution to dissolution in aqueous buffer and solutions of solubilizer. RSC Advances. 2024. 14. 6. 4129-4141
Nakai, K., Lin, H., Yamano, S., Tanaka, S., Kitamoto, S., Saitoh, H., Sakuma, K., Kurauchi, J., Akter, E., Konno, M., Ishibashi, K., Kamato, R., Ohashi, A., Koseki, J., Takahashi, H., Yokoyama, H., Shiraki, Y., Enomoto, A., Abe, S., Hayakawa, Y., Ushiku, T., Mutoh, M., Fujita, Y. & Kon, S. Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway. Nature Communications. 2023. 14. 1. 7048-7048
Hasegawa, K., Goto, S., Tsunoda, C., Kuroda, C., Okumura, Y., Hiroshige, R., Wada-Hirai, A., Shimizu, S., Yokoyama, H.. & Tsuchida, T. Using singular value decomposition to analyze drug/β-cyclodextrin mixtures: insights from X-ray powder diffraction patterns. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2023. 25. 42. 29266-29282
Tsunoda, C., Hasegawa, K., Hiroshige, R., Kasai, T., Yokoyama, H. & Goto, S. Effect of cyclodextrin complex formation on solubility changes of each drug due to intermolecular interactions between acidic NSAIDs and basic H2 blockers. MOLECULAR PHARMACEUTICS. 2023. 20. 10. 5032-5042

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MISC (27)：

Yokoyama, H., Suzuki, A. & Shibuya, A. Structure of kinesin CENP-E motor domain in complex with an ATP analogue. Photon Factory Activity Report 2022. 2023. 40. B. 126-126
渋谷明日香、鈴木翠、横山英志. キネシンCENP-EとATPアナログの複合体のX線結晶構造解析. Photon Factory Activity Report 2021. 2022. 39. B. 141-141
Shibuya, A., Ogo, N., Sawada, J., Asai, A., Yokoyama, H. Structure determination of the motor domain of centromere-associated protein E. Acta Crystallographica A-Foundation and Advances. 2021. 77. C. 709-709
渋谷明日香、横山英志. キネシンCENP-Eの構造解析とその機能の解明. Photon Factory Activity Report 2020. 2021. 38. B. 192-192
渋谷明日香、横山英志. キネシンCENP-Eを用いた結晶化とX線回折データの分解能の改善. Photon Factory Activity Report 2019. 2020. 37. B. 56-56

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Books (7)：

理大科学フォーラム「編集後記」
東京理科大学 2020
理大科学フォーラム「つれづれぐさ時間の使い方」
東京理科大学 2018
FD通信 2018.6Vol.54「薬学部生命創薬科学科「薬品物理化学2」における授業収録配信システム利用例」
東京理科大学教育開発センター / FD啓発・広報小委員会 2018
理工系の基礎薬学
丸善出版 2018
Conscience 2018.3. Vol.119 「クイズで学ぶScience(先生方の研究をクイズ形式で紹介!!)」
学校法人東京理科大学広報課 2018

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Lectures and oral presentations (100)：

薬物が示す脂質膜揺動性向上作用と脂質過酸化抑制効果の相関性の検討
(界面科学研究部門2023年度成果報告会 2024)
CENP-Eモータードメインの加水分解前後の結晶構造の比較
(第61回日本生物物理学会年会 2023)
キネシンCENP-Eモータードメインと阻害剤の複合体調製と結晶化
(令和5年度日本結晶学会年会 2023)
Crystallization of podocin, associated with nephrotic syndrome
(26th Congress and General Assembly of the International Union of Crystallography 2023)
ネフローゼ症候群原因タンパク質podocinの結晶化
(日本薬学会第143年会 2023)

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Education (2)：

- 2002 The University of Tokyo Graduate School of Pharmaceutical Sciences
- 1997 The University of Tokyo Faculty of Pharmaceutical Sciences

Committee career (1)：

2018/04 - 2020/03 日本薬学会物理系薬学部会関東ブロック世話人

Awards (1)：

2009/07/11 - 膜タンパク質ストマチンの三次元構造

Association Membership(s) (1)：

日本薬学会物理系薬学部会

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