Rchr
J-GLOBAL ID:201901006888780916   Update date: Apr. 06, 2024

Sefan Asamitsu

アサミツ セファン | Sefan Asamitsu
Affiliation and department:
Research field  (2): Molecular biology ,  Neuroscience - general
Research keywords  (4): 非コードゲノム科学 ,  神経科学 ,  ケミカルバイオロジー ,  核酸化学
Research theme for competitive and other funds  (7):
  • 2024 - 2025 生きた脳でDNA高次構造を網羅的に捉える技術の開発
  • 2023 - 2025 RNA化学修飾操作技術を用いた脳エピトランスクリプトミクス制御の解明
  • 2021 - 2024 生きた脳でDNA高次構造を網羅的に捉える技術の開発
  • 2020 - 2023 筋強直性ジストロフィーの病態解明と症状改善薬の開発
  • 2020 - 2023 Visualization of specific RNA secondary structures in vivo
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Papers (30):
  • Susumu Ikenoshita, Kazuya Matsuo, Yasushi Yabuki, Kosuke Kawakubo, Sefan Asamitsu, Karin Hori, Shingo Usuki, Yuki Hirose, Toshikazu Bando, Kimi Araki, et al. A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models. The Journal of clinical investigation. 2023
  • Kenta Kudo, Karin Hori, Sefan Asamitsu, Kohei Maeda, Yukari Aida, Mei Hokimoto, Kazuya Matsuo, Yasushi Yabuki, Norifumi Shioda. Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with CANVAS. bioRxiv. 2023
  • Kazuya Matsuo, Sefan Asamitsu, Kohei Maeda, Kosuke Kawakubo, Ginji Komiya, Kenta Kudo, Yusuke Sakai, Karin Hori, Susumu Ikenoshita, Shingo Usuki, et al. RNA G-quadruplexes forming scaffolds for alpha-synuclein aggregation lead to progressive neurodegeneration. bioRxiv. 2023
  • Sefan Asamitsu, Yasushi Yabuki, Kazuya Matsuo, Moe Kawasaki, Yuki Hirose, Gengo Kashiwazaki, Anandhakumar Chandran, Toshikazu Bando, Dan Ohtan Wang, Hiroshi Sugiyama, et al. RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons. Science advances. 2023. 9. 8. eade2035
  • Yousuke Katsuda, Shin-ichi Sato, Maimi Inoue, Hisashi Tsugawa, Takuto Kamura, Tomoki Kida, Rio Matsumoto, Sefan Asamitsu, Norifumi Shioda, Shuhei Shiroto, et al. Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation. Nucleic Acids Research. 2022
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MISC (2):
Patents (1):
  • リピート結合剤
Books (3):
  • Brain Science Dictionary
    2022
  • Development of Selective DNA-Interacting Ligands - Understanding the Function of Non-canonical DNA Structures
    Springer 2020
  • Annual Reports in Medicinal Chemistry
    2020
Education (3):
  • 2016 - 2019 Kyoto University Graduate School of Science Division of Chemistry
  • 2014 - 2016 Kyoto University Graduate School of Science Division of Chemistry
  • 2010 - 2014 Kyoto University Faculty of Science Faculty of Science
Professional career (1):
  • 博士(理学) (京都大学)
Work history (6):
  • 2023/04 - 現在 理化学研究所 生命医科学研究センター 研究員
  • 2020/04 - 2023/03 日本学術振興会特別研究員 PD
  • 2019/04 - 2020/03 Kumamoto University Institute of Molecular Embryology and Genetics
  • 2017/04 - 2019/03 日本学術振興会 特別研究員(DC2)
  • 2017/10 - 2017/11 Nanyang Technological University, visiting scholar (Prof. Anh Tuân Phan)
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Awards (2):
  • 2020/05 - Springer Theses Award for Outstanding Ph.D. Research
  • 2019/10 - 肥後医育振興会学術奨励賞
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