Fujita Hikaru

フジタヒカル | Fujita Hikaru

Affiliation and department：
Homepage URL (1)： http://bioorg.w3.kanazawa-u.ac.jp/

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (5)：有機色素 , アルキル化剤 , トリアジン , 生物有機化学 , 有機化学

Research theme for competitive and other funds (11)：

2023 - 2026 テトラアリールアンモニウムの合成法の開発
2023 - 2026 薬物代謝反応に及ぼす小胞体膜輸送体の役割解明
2023 - 2025 低極性場中で誘導される新規光ラベル化反応の開発
2022 - 2024 CKD予防・治療手法の提唱を目指した尿毒症物質の腎毒性トリガータンパク質の同定
2021 - 2024 カルボカチオンの制御に関する方法論の確立と求核置換反応への展開

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Papers (37)：

Hikaru Fujita, Tomomi Yagitani, Munetaka Kunishima. Alkoxy Exchange Strategy for the Synthesis of N,N′-Dimethylated (Alkoxy)triazinediones as Solid Reagents for Acid-Catalyzed O-Alkylation. The Journal of Organic Chemistry. 2024. 89. 20. 15302-15306
Hikaru Fujita, Takanari Arai, Naoto Kuchiki, Munetaka Kunishima. Bicyclic-Ammonium-Incorporated Ylidic Nitrogen Groups for Strong π-Electron Donation in Push-Pull Benzene π-Conjugated Systems. Organic Letters. 2024. 26. 35. 7313-7317
Munetaka Kunishima, Hikaru Fujita, Toshiyuki Kato, Tatsuki Betsuyaku. Development of a Purely Isolable (Dimorpholino)triazine-Based Reagent for the Epoxidation of Alkenes. Synlett. 2024. (in press)
Hikaru Fujita, Daichi Shimada, Jotaro Kudo, Kazuyuki Kosha, Satoshi Kakuyama, Hiromitsu Terasaki, Munetaka Kunishima. Carbocationoids, a concept for controlling highly reactive cationic species. Communications Chemistry. 2024. 7. 1. 55
Hikaru Fujita, Sachiko Arai, Hiroshi Arakawa, Kana Hamamoto, Toshiyuki Kato, Tsubasa Arai, Nanaka Nitta, Kazuki Hotta, Natsuko Hosokawa, Takako Ohbayashi, et al. Drug-drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers. Bioorganic & Medicinal Chemistry. 2024. 102. 117674-117674

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Patents (5)：

Northern-Southern Route to Synthesis of Bacteriochlorins.
Compounds and methods useful in brachytherapy
水酸基保護化剤及び水酸基保護方法
Hydroxy Group Protecting Agent and Hydroxy Group Protection Method.
ハイブリッド型化合物又はその塩

Books (1)：

2,4,6-Tris(P-methoxybenzyloxy)-1,3,5-triazine (TriBOT-PM). In Encyclopedia of Reagents for Organic Synthesis
Wiley 2021

Lectures and oral presentations (68)：

Synthesis of benzofurazan-based fluorescent dyes bearing ammonioamidyl groups
(2024)
Hofmann脱離分解に耐性を持つ第四級アンモニウム骨格の設計と合成
(創薬懇話会2024 in 札幌 2024)
Synthesis of triphenylamines bearing a silicon substituent at the ortho position
(2024)
SN1反応の高活性中間体を取り出す新規方法論:カルボカチオノイド
(日本薬学会第144年会 2024)
gem-ジヨードニオアルケンのヨードニオ基置換反応の開発検討
(日本薬学会第144年会 2024)

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Education (3)：

2012 - 2016 Kanazawa University Graduate school of Medical Sciences Division of Pharmacy Ph.D. in Pharmacy
2006 - 2012 Kanazawa University Faculty of Pharmaceutical Sciences Bachelor of Pharmacy
2003 - 2006 金沢大学教育学部附属高等学校

Professional career (1)：

Ph.D (Kanazawa University)

Work history (5)：

2020/05 - 現在 Kanazawa University Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences Assistant professor
2019/04 - 2020/04 Organization of Frontier Science and Innovation Venture Business Laboratory Postdoctoral Researcher
2016/09 - 2019/03 North Carolina State University Department of Chemistry Postdoctoral Researcher
2016/04 - 2016/09 Kanazawa University
2013/04 - 2016/03 Japan Society for the Promotion of Science JSPS Fellow (DC1)

Committee career (1)：

2022/04 - 2023/03 金沢大学角間地区安全衛生委員会衛生管理者

Awards (3)：

2013/10 - 第43回複素環化学討論会最優秀講演賞酸触媒トリアジン型パラメトキシベンジル化剤(TriBOT-PM)の開発
2012/11 - 第38回反応と合成の進歩シンポジウム優秀発表賞究極的に簡素化されたイミダート等価構造を持つ新規ベンジル化剤:TriBOT
2012/03 - 日本薬学会第133年会優秀発表賞トリベンジルオキシトリアジン(TriBOT)を用いた新規酸触媒O-ベンジル化反応

Association Membership(s) (5)：

The Chemical Society of Japan , THE JAPANESE SOCIETY FOR PROCESS CHEMISTRY , THE JAPANESE PHOTOCHEMISTRY ASSOCIATION , THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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