HIsashi Goto

Affiliation and department：

Research field (1)： Cell biology

Research theme for competitive and other funds (6)：

2020 - 2023 Ebi3-/-マウスを用いた実験的歯周炎におけるIL-35の付着上皮への影響
2020 - 2023 Immunomodulatory mechanism of P gingivalis Mfa1 fimbriae in periodontal tissue destruction
2017 - 2022 Development of the new regenerative medicine technique by applying the mechanism of the cytoskeleton reorganization.
2017 - 2021 The analysis about the role of fimbrie from periodontal pathogenic bacteria for the periodontal tissue destruction
2017 - 2019 Effect of IL-35 on gingival epithelial cell

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Papers (11)：

Hisashi Goto, Takeshi Kikuchi, Yuhei Takayanagi, Yosuke Kamiya, Yuki Suzuki, Shotaro Kawamura, Noritaka Sawada, Jun-ichiro Hayashi, Akio Mitani. Ebi3 knockout aggravates experimental periodontitis via Th17 polarization. Journal of Clinical Periodontology. 2023. 50. 10. 1406-1418
Yuki Suzuki, Takeshi Kikuchi, Hisashi Goto, Yuhei Takayanagi, Shotaro Kawamura, Noritaka Sawada, Yoshikazu Naiki, Hisataka Kondo, Jun-Ichiro Hayashi, Yoshiaki Hasegawa, et al. Porphyromonas gingivalis Fimbriae Induce Osteoclastogenesis via Toll-like Receptors in RAW264 Cells. International journal of molecular sciences. 2022. 23. 23
Yuhei Takayanagi, Takeshi Kikuchi, Yoshiaki Hasegawa, Yoshikazu Naiki, Hisashi Goto, Kousuke Okada, Iichiro Okabe, Yosuke Kamiya, Yuki Suzuki, Noritaka Sawada, et al. Porphyromonas gingivalis Mfa1 Induces Chemokine and Cell Adhesion Molecules in Mouse Gingival Fibroblasts via Toll-Like Receptors. Journal of clinical medicine. 2020. 9. 12
菊池毅, 岡部猪一郎, 岡田康佑, 大野祐, 後藤久嗣, 藤村岳樹, 菱川敏光, 山本弦太, 福田光男, 三谷章雄. 歯周病における組織破壊に関する免疫学的考察. 日本歯周病学会会誌 (0385-0110)59巻4号 Page185-190(2017.12). 2017. 59. 4. 185-190
Tasuku Ohno, Genta Yamamoto, Jun-ichiro Hayashi, Eisaku Nishida, Hisashi Goto, Yasuyuki Sasaki, Takeshi Kikuchi, Mitsuo Fukuda, Yoshiaki Hasegawa, Makio Mogi, et al. Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells. PLOS ONE. 2017. 12. 9. e0184825

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