J-GLOBAL ID:201901007342412386   Update date: Nov. 16, 2021

Alessandro Nasti

Alessandro Nasti
Affiliation and department:
Job title: Postdoctoral Fellow
Research field  (3): Other ,  Tumor diagnostics and therapeutics ,  Immunology
Research keywords  (5): Pancreatic ductal adenocarcinoma (PDAC) ,  Hepatitis ,  Immunotherapy ,  Adult stem/stromal adipose tissue-derived cells (ADSCs) ,  Regenerative therapy
Research theme for competitive and other funds  (3):
  • 2020 - 2023 Study of liver restorative therapy for a murine nonalcoholic steatohepatitis model by the administration of immune-suppressive fractions of autologous adipose tissue-derived stromal cells
  • 2021 - 2022 Development of pancreatic cancer immunotherapy using bispecific antibodies
  • 2014 - 2017 Analysis of characteristics of cellular subfractions in adipose tissue-derived stromal cells for development of liver repair/regenerative therapy
Papers (17):
  • Yoshio Sakai*, Alessandro Nasti*, Yumie Takeshita, Miki Okumura, Shinji Kitajima, Masao Honda, Takashi Wada, Seiji Nakamura, Toshinari Takamura, Takuro Tamura, et al. Eight-year longitudinal study of whole blood gene expression profiles in individuals undergoing long-term medical follow-up. Scientific Reports. 2021. 11. 1
  • Kosuke Ishida, Akihiro Seki, Kazunori Kawaguchi, Alessandro Nasti, Masatoshi Yamato, Hiiro Inui, Takuya Komura, Taro Yamashita, Kuniaki Arai, Tatsuya Yamashita, et al. Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice. Stem Cell Research. 2021. 54. 102425-102425
  • Yoshio Sakai, Shinya Fukunishi, Masayuki Takamura, Kazunori Kawaguchi, Oto Inoue, Soichiro Usui, Shinichiro Takashima, Akihiro Seki, Akira Asai, Yusuke Tsuchimoto, et al. Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy. Regenerative Therapy. 2021. 18. 97-101
  • Tuyen Thuy Bich Ho*, Alessandro Nasti*, Akihiro Seki, Takuya Komura, Hiiro Inui, Takashi Kozaka, Yoji Kitamura, Kazuhiro Shiba, Taro Yamashita, Tatsuya Yamashita, et al. Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis. Journal for ImmunoTherapy of Cancer. 2020. 8. 2. e001367-e001367
  • Yoshio Sakai, Shinya Fukunishi, Masayuki Takamura, Oto Inoue, Shinichiro Takashima, Soichiro Usui, Akihiro Seki, Alessandro Nasti, Tuyen Thuy Bich Ho, Kazunori Kawaguchi, et al. Regenerative Therapy for Liver Cirrhosis Based on Intrahepatic Arterial Infusion of Autologous Subcutaneous Adipose Tissue-Derived Regenerative (Stem) Cells: Protocol for a Confirmatory Multicenter Uncontrolled Clinical Trial. JMIR Research Protocols. 2020. 9. 3. e17904-e17904
MISC (12):
  • Alessandro Nasti, Yoshio Sakai, Norihiko Ogawa, Masaki Miyazawa, Shingo Inagaki, Tuyen Thuy Bich Ho, Hiroki Nomura, Akihiro Seki, Kyo Kume, Munetoshi Maeda, et al. Antitumor effect of proton beam irradiation and anti-PD-L1 antibody combination therapy in subcutaneous murine models of pancreatic cancer. European Journal of Immunology. 2021. 51 (Suppl. 1). 1-448
  • Haruo Fujinaga, Yoshio Sakai, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Takuya Komura, Akihiro Seki, Kazunori Kawaguchi, Nasti Alessandro, Keiko Yoshida, Takashi Wada, Yasu Kume, Takashi Hasegawa, Takushi Takada, Masao Honda, Shuichi Kaneko. ABSTRACT O-190: Characteristics of changes in gene expression profile during proton/X-ray irradiation of pancreatic cancer cell lines. Suizō (Pancreas; in Japanese). 2018. 33. 3. 468-468
  • Takuya Komura, Yoshio Sakai, Hisashi Takabatake, Keiko Yoshida, Mai Okuzono, Alessandro Nasti, Takeshi Yamada, Shuichi Kaneko. ABSTRACT SY2-1. Changes in host immune response caused by Gemcitabine treatment in a mouse model of pancreatic cancer. Suizō (Pancreas; in Japanese). 2018. 33. 3. 322-322
  • Alessandro Nasti, Yoshio Sakai, Akihiro Seki, Geraldine Belen Buffa, Takuya Komura, Hatsune Mochida, Masatoshi Yamato, Keiko Yoshida, Tuyen T. B. Ho, Masayuki Takamura, et al. Eur. J. Immunol. 12'17. European Journal of Immunology. 2017. 47. 12. Cover Picture-NA
  • Masatoshi Yamato, Yoshio Sakai, Hatsune Mochida, Akihiro Seki, Keiko Yoshida, Tuyen T. Ho, Alessandro Nasti, Takashi Wada, Shuichi Kaneko. ABSTRACT: Adipose tissue derived stromal/stem cells retarded progression of hepatic fibrosis by suppressing IL17A related inflammation in early stage of NASH. HEPATOLOGY. 2017. 66. 1041A-1041A
Patents (4):
  • Response prediction markers for chemotherapeutic agents for pancreatic cancer and biliary tract cancer, and corresponding response prediction kits
  • Combination of chemotherapeutic agent and anti-cancer immunity enhancers
  • Stem cell manufacturing method
  • Pharmaceutical compositions based on porous zeolites as release means of pharmacologically active molecules and relative use.
Books (2):
  • Thesis/Dissertation: The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells
  • Thesis: Chitosan-based nanoparticles and microparticles
Lectures and oral presentations  (41):
  • Radiobiological studies for the advancement of multidisciplinary treatment with proton therapy at the Wakasa Wan Energy Research Center
    (The 64th Annual Meeting of the Japan Radiation Research Society)
  • Antitumor effect by proton irradiation and anti-PD-L1 antibody administration in a subcutaneous model of pancreatic cancer mice
    (52nd Annual Meeting of the Japanese Pancreatic Society)
  • Antitumor effect of proton beam irradiation and anti-PD-L1 antibody combination therapy in subcutaneous murine models of pancreatic cancer
    (6th European Congress of Immunology (ECI 2021) 2021)
  • Therapeutic effect of Gemcitabine and anti-PD-1 antibody administration in a mouse model of pancreatic cancer liver metastasis
    (51st Annual Meeting of the Japanese Pancreatic Society 2021)
  • Search for blood biomarkers for prediction of prognosis in patients with unresectable pancreatic cancer receiving FOLFIRINOX therapy
    (51st Annual Meeting of the Japanese Pancreatic Society 2021)
Education (6):
  • 2011 - 2018 Kanazawa University Graduate School of Medical Science. Department of Graduate School of Advanced Preventive Medical Sciences (System Biology), Kanazawa, Japan PhD in Medical Sciences
  • 2006 - 2008 The University of Manchester School of Pharmacy and Pharmaceutical Sciences. Laboratory of Polymers and Biomaterials, Manchester, UK Doctoral study exchange programme
  • 2005 - 2008 Università degli Studi di Napoli Federico II Faculty of Pharmacy, Napoli, Italy PhD in Medicinal Chemistry
  • 1999 - 2004 Università degli Studi di Napoli Federico II Faculty of Pharmacy, Napoli, Italy Master of Sciences of Pharmacy (MPharm)
  • 2002 - 2003 Procter & Gamble Italian Research Center, Pescara, Italy Research Internship
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Professional career (3):
  • PhD in Medical Sciences (Kanazawa University; Kanazawa, JAPAN)
  • PhD in Medicinal Chemistry (University of Naples Federico II; Naples, ITALY)
  • Master in Pharmacy (University of Naples Federico II; Naples, ITALY)
Work history (3):
  • 2011/10 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences; System Biology, Kanazawa, Japan Engaged in the research of immunotherapies for the diseases of the gastrointestinal tract: specifically for liver and intestinal diseases. Postdoctoral Researcher
  • 2009/05 - 2011/09 Lincoln County Hospital, UK National Health Service (NHS), Lincoln, UK Provided service to wards and departments, exercised professional supervision over clinical use of drugs in patients. Rotational Clinical Pharmacist
  • 2009/03 - 2009/04 The University of Manchester, School of Pharmacy and Pharmaceutical Sciences. Laboratory of Polymers and Biomaterials, Manchester, UK Support and supervision of PhD students. Focused on the preparation of biocompatible nanoparticles and microparticles for drug delivery. Honorary Research Associate
Awards (1):
  • 2021/02 - Kanazawa University Papers of the Month Project Blending the old and the new to fight pancreatic cancer
Association Membership(s) (1):
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