2020 - 2022 Research on the establishment of a new preventive approach to cerebrovascular disease
2019 - 2020 Study on induced of neuroprotective effects by combined use of remote ischemic preconditioning and preconditioning exercise.
Papers (22)：
Shotaro Otsuka, Kiyoshi Kikuchi, Yasufumi Takeshita, Seiya Takada, Akira Tani, Harutoshi Sakakima, Ikuro Maruyama, Hyuma Makizako. Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study. Frontiers in aging neuroscience. 2024. 16. 1337397-1337397
Kiyoshi Kikuchi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Kentaro Setoyama, Harutoshi Sakakima, Eiichiro Tanaka, Ikuro Maruyama. 1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5'-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway. Aging. 2023. 15. 21. 11740-11763
Kosuke Norimatsu, Kazuki Nakanishi, Toshiro Ijuin, Shotaro Otsuka, Seiya Takada, Akira Tani, Ryoma Matsuzaki, Teruki Matsuoka, Harutoshi Sakakima. Effects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8. Arthritis research & therapy. 2023. 25. 1. 168-168
Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Teruki Matsuoka, Ryoma Matsuzaki, Shogo Kakimoto, Nao Nojima, Yuta Tachibe, Yuki Kato, Masaki Inadome, et al. Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8. Neuroscience letters. 2023. 808. 137297-137297
Akira Tani, Harutoshi Sakakima, Shotaro Otsuka, Keita Mizuno, Kazuki Nakanishi, Kosuke Norimatsu, Seiya Takada, Teruki Matsuoka, Ryoma Matsuzaki, Tomomi Nakakogawa, et al. Stimulation of functional recovery via neurorepair mechanisms by the traditional Japanese Kampo medicine, Ninjin'yoeito, and physical exercise in a rat ischemic stroke model. Journal of ethnopharmacology. 2023. 302. Pt B. 115927-115927
