Hirata Tetsuya

Research field (1)： Structural biochemistry

Research keywords (7)： Forward genetic screening , Palmitoylation , Biochemistry , Glycoscience , GPI-anchor , N-glycosylation , Neuroscience

Research theme for competitive and other funds (11)：

2021 - 2024 Mechanism for diversifying the branched structure of GPI elucidated by interdisciplinary research in glycochemistry and glycobiology
2020 - 2023 GPIアンカー側鎖の生理機能と疾患との関連の解明
2021 - 2022 神経分化にともなう糖脂質 GPI の糖鎖構造変化の意義の解明
2021 - 2022 化学合成した糖脂質GPIアンカーを基質としたGPI糖鎖生合成メカニズムの解明
2020 - 2022 糖脂質GPIの糖鎖構造多様化メカニズムの解明

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Papers (27)：

Atsushi Kobayashi, Tetsuya Hirata, Taishi Shimazaki, Yoshiko Munesue, Keisuke Aoshima, Takashi Kimura, Junko Nio-Kobayashi, Rie Hasebe, Atsuko Takeuchi, Yuichi Matsuura, et al. A point mutation in GPI-attachment signal peptide accelerates the development of prion disease. Acta neuropathologica. 2023. 145. 5. 637-650
Tetsuya Hirata, Yoichiro Harada, Koichiro M. Hirosawa, Yuko Tokoro, Kenichi G.N. Suzuki, Yasuhiko Kizuka. N-Acetylglucosaminyltransferase-V (GnT-V)-enriched small extracellular vesicles mediate N-glycan remodeling in recipient cells. iScience. 2022. 105747-105747
Tetsuya Hirata, Jing Yang, Seita Tomida, Yuko Tokoro, Taroh Kinoshita, Morihisa Fujita, Yasuhiko Kizuka. ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequence. The Journal of biological chemistry. 2022. 298. 10. 102444-102444
Naoko Osada, Masamichi Nagae, Miyako Nakano, Tetsuya Hirata, Yasuhiko Kizuka. Examination of differential glycoprotein preferences of N-acetylglucosaminyltransferase-IV isozymes a and b. The Journal of biological chemistry. 2022. 298. 9. 102400-102400
Tetsuya Hirata, Misaki Takata, Yuko Tokoro, Miyako Nakano, Yasuhiko Kizuka. Shedding of N-acetylglucosaminyltransferase-V is regulated by maturity of cellular N-glycan. Communications biology. 2022. 5. 1. 743-743

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MISC (5)：

大須賀玲奈, 平田哲也, 長江雅倫, 木塚康彦. 糖転移酵素GnT-Vに特異的な非触媒ドメインを介した糖タンパク質基質認識機構. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [2T13m-064)]
大須賀玲奈, 平田哲也, 長江雅倫, 木塚康彦, 木塚康彦. Mechanism of substrate recognition by GnT-V. 日本糖質学会年会要旨集. 2021. 40th
富田晟太, 高田実咲, 平田哲也, 長江雅倫, 中の三弥子, 木塚康彦, 木塚康彦. FUT8にユニークなSH3ドメインの機能解明. 日本生化学会大会(Web). 2020. 93rd
富田晟太, 平田哲也, 長江雅倫, 木塚康彦, 木塚康彦. FUT8 SH3ドメインの機能解析. 日本糖質学会年会要旨集. 2019. 38th
T. Hirata, Y. Fukata, M. Fukata. Palmitoylation/depalmitoylation enzymes in neuroscience research. Biochemistry. 2018. 90. 2. 125-137

Education (2)：

Professional career (1)：

Work history (5)：

2022/04 - 現在 Duke University Department of Biochemistry, School of Medicine Research Scholar
2019/04 - 2022/03 Gifu University G-CHAIN Specially-Appointed Assistant Professor
2017/04 - 2019/03 National Institute for Physiological Sciences Division of Membrane Physiology Project Assistant Professor
2016/04 - 2017/03 Osaka University Research Institute for Microbial Diseases Specially Appointed Researcher (Full time)
2014/04 - 2016/03 Osaka University Research Institute for Microbial Diseases JSPS Research Fellow (DC2)

Committee career (2)：

Awards (2)：

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