Rchr
J-GLOBAL ID：201901008146812534
Update date: Apr. 11, 2024
Toyooka Shinichi
トヨオカ シンイチ | Toyooka Shinichi
Affiliation and department：
Homepage URL (1)：
http://www.nigeka-okayama-u.jp/message/
Research field (1)：
Respiratory surgery
Research theme for competitive and other funds (55)：
- 2023 - 2027 Development of a novel therapeutic strategy targeting the microenvironment that tolerates the progression of refractory lung cancer
- 2023 - 2027 Functional analysis of TLS, tumor-infiltrating B-cell, by spatial multi-omics profiling and its application to tumor immunotherapy
- 2022 - 2027 耐性化機序に基づいたHER2陽性乳癌に対する治療戦略の開発
- 2023 - 2026 メタゲノム解析によるCOPD合併肺がんの臓器横断的ディスバイオーシスの解明
- 2023 - 2026 S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
- 2023 - 2026 Elucidation of Tumor Microenvironment Network Regulated by Fibrinolysis Inhibitory Factor and Its Therapeutic Application
- 2023 - 2026 同種造血細胞移植後閉塞性細気管支炎におけるマクロファージ標的治療の開発
- 2023 - 2026 Identification of genetic loci associated with chronic lung allograft dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array
- 2023 - 2026 空間マルチオミックスを用いた慢性肺GVHDとの比較による慢性移植肺機能不全の病態解明
- 2022 - 2026 マトリセルラータンパク質阻害によるがん微小環境の破壊と抗腫瘍効果の検討
- 2022 - 2025 Clarification of the mechanism for endogenous retrovirus to get involved in the antitumor immunity response
- 2022 - 2025 抗炎症タンパク質HRGに着眼した肺虚血再灌流障害に対する新規治療法の開発
- 2022 - 2025 Creating new therapies for lung cancer by targeting de-differentiated Schwann cells in the cancer microenvironment.
- 2021 - 2024 Exploration of the novel therapeutic target for lung cancer based on the analysis of the characteristics of tumor cells derived from 3D culture
- 2020 - 2024 心停止ドナーからの肺移植後虚血再灌流障害のトランスレーショナルリサーチと治療応用
- 2020 - 2023 組織障害性HMGB1に着眼した肺虚血再灌流障害に対する新規戦略の確立
- 2020 - 2023 家族性肺癌に対する、次世代シーケンサーを用いた胚細胞性遺伝子変異と治療法の探索
- 2020 - 2023 Development of next-generation precision medicine targeting the pathways on which driver gene mutation-positive lung cancer depends
- 2020 - 2023 新規S100A8/A9阻害分子の発見に基づいたがん脳指向転移の機構解明とその制御
- 2020 - 2023 肺虚血再灌流障害におけるS100A8/A9の役割の解明と新しい治療法の開発
- 2019 - 2022 A novel diagnostic approach for chronic lung allograft dysfunction after lung transplantation
- 2019 - 2022 Development of a new treatment strategy for HER2-alterated lung cancer
- 2019 - 2022 Treatment strategy overcoming HER2 targetted drug resistance
- 2019 - 2022 Development of the novel therapy focused on damage-associated molecular patterns (DAMPs) for lung fibrosis-related diseases
- 2019 - 2022 Development of transplanted lung function-preserving method using a mouse model focusing on the anti-inflammatory related molecule Spred2
- 2019 - 2022 Novel treatment strategy for malignant pleural mesothelioma targeting the tumor stem cell marker DCLK1
- 2018 - 2021 Development of innovative therapeutic antibodies targeting the inflammatory tumor microenvironment in refractory thoracic tumors
- 2018 - 2021 Novel therapeutic strategy focused on EGFR-binding protein LRIG1 for EGFR-mutant lung cancer
- 2017 - 2020 Gene mutation analysis using molecular-barcoding next-generation sequencer
- 2017 - 2020 Research to construct a novel strategy of identifying for comprehensive acquired resistance to chemotherapy with anti-EGFR antibody.
- 2017 - 2020 Mechanistic analysis of an unidentified downstream signals of S100A8/A9 receptors that play a crucial role in acquisition of metastatic force and formation of cancer microenvironment.
- 2016 - 2019 Novel therapeutic method for HER2 active cancer focusing on HER2 novel binding molecule cytokeratin 19
- 2016 - 2019 Development of new therapeutic strategy based on gene expression and mutation profiles in EGFR mutant lung cancer
- 2016 - 2019 Development of new immunotherapy for lung cancer by combined application of diabetes drug metformin and anti-PD-1 antibody
- 2015 - 2018 Development of new therapeutic strategy for EGFR-TKI resistant non-small cell lung cancer.
- 2015 - 2018 Innovation and clinical application of lung cancer screening modality using microbead-based technology
- 2015 - 2018 Donor-derived cell-free DNA is associated with acute rejection and decreased oxygenation in primary graft dysfunction after living donor-lobar lung transplantation
- 2016 - 2017 EGFR-TKI resistance and epigenetic alterations in lung cancer treatment
- 2015 - 2017 exSSSRs-Fc fusion decoys prevent S100A8/A9-mediated cancer metastasis.
- 2014 - 2017 New therapeutic strategy for non-small cell lung cancer by REIC gene therapy
- 2014 - 2017 Identification of novel targets in the treatment of lung cancer
- 2013 - 2016 New treatment strategy for malignant pleural mesothelioma focusing on microRNAs related to cancer stem cell makers
- 2013 - 2016 Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer
- 2012 - 2014 Anti tumor effect of micro RNA transferred by active targeting liposomes
- 2011 - 2013 Establishment of the high sensitive assay for detecting malignant pleural mesothelioma-specific DNA methylation
- 2011 - 2013 Detection of aberrant expression of microRNAs and development of new diagnostics and treatment in lung cancer
- 2011 - 2013 The development of novel therapy with microRNA in gastric cancer
- 2010 - 2012 Development of the new therapeutic approach for malignant pleural mesothelioma by the elucidation of aberrant microRNA expression
- 2010 - 2012 Radiofrequency ablation for pulmonary aspergilloma
- 2010 - 2012 Establishment of a genetic diagnosis system for cancer predispositionand its application to cancer prevention.
- 2008 - 2009 がん発症前高リスクに関わるがん体質遺伝診断法の確立
- 2007 - 2009 The serum level of de novo donor specific antibody can predict acute rejection in lung transplantation.
- 2006 - 2007 肺癌の個別化治療を目指した遺伝子異常と分子標的治療薬の効果に関する検討
- 2006 - 2007 Experimental Study on Microthrombi Formation for Lung Transplantation from Non-Heart-Beating Donor
- 2003 - 2006 An experimental study about development of the ventilator for total liquid ventilation and its optimal respiratory setting.
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Papers (878)：
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Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, et al. Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface. Frontiers in Oncology. 2024. 14
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Yujiro Kubo, Hiromasa Yamamoto, Kei Matsubara, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, et al. Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery. Surgery today. 2024
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Toshio Shiotani, Seiichiro Sugimoto, Yasuaki Tomioka, Shin Tanaka, Toshiharu Mitsuhashi, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, et al. Plasma concentrations of histidine-rich glycoprotein in primary graft dysfunction after lung transplantation. Interdisciplinary cardiovascular and thoracic surgery. 2024
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Yasuaki Tomioka, Seiichiro Sugimoto, Toshio Shiotani, Kei Matsubara, Haruki Choshi, Megumi Ishihara, Shin Tanaka, Kentaroh Miyoshi, Shinji Otani, Shinichi Toyooka. Long-term outcomes of lung transplantation requiring renal replacement therapy: A single-center experience. Respiratory investigation. 2024. 62. 2. 240-246
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Yasuaki Tomioka, Shinji Otani, Shin Tanaka, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka. Successful Living-donor Lobar Lung Transplantation With BK Virus-related Hemorrhagic Cystitis Throughout the Perioperative Period. Transplantation direct. 2024. 10. 1. e1556
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MISC (615)：
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T. Habu, H. Yamamoto, K. Nakata, K. Hashimoto, S. Tanaka, K. Suzawa, K. Shien, K. Miyoshi, M. Okazaki, S. Sugimoto, et al. EP07.01-12 A Retrospective Study on the Methods of Covering Bronchial Stump/Anastomotic Site to Avoid the Bronchopleural Fistula after Lung Cancer Surgery. Journal of Thoracic Oncology. 2023. 18. 11. S512-S513
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庄田 浩康, 池田 慧, 坪井 正博, 坂井 和子, 三角 俊裕, 赤松 弘朗, 棚橋 雅幸, 丹保 裕一, 齋藤 春洋, 豊岡 伸一, et al. 完全切除後II-III期のEGFR変異陽性非小細胞肺癌に対する第III相IMPACT試験における付随バイオマーカー研究. 肺癌. 2023. 63. 5. 499-499
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Y. Kubo, S. Sugimoto, H. Choshi, H. Ujike, S. Kawana, D. Shimizu, K. Matsubara, K. Hashimoto, S. Tanaka, K. Shien, et al. (258) Histidine-Rich Glycoprotein Ameliorates Lung Ischemia-Reperfusion Injury in a Mouse. The Journal of Heart and Lung Transplantation. 2023. 42. 4. S124-S125
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S. Kawana, S. Sugimoto, K. Matsubara, S. Tanaka, K. Miyoshi, H. Choshi, H. Ujike, Y. Kubo, D. Shimizu, K. Hashimoto, et al. (347) Augmented Humoral Response to a Third And Fourth Dose of Mrna Sars-Cov-2 Vaccines in Lung Transplant Recipients. The Journal of Heart and Lung Transplantation. 2023. 42. 4. S164-S165
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H. Ujike, S. Tanaka, H. Choshi, S. Kawana, Y. Kubo, D. Shimizu, K. Matsubara, K. Hashimoto, K. Shien, K. Suzawa, et al. (891) Bilateral Lung Transplantation from Living Donors in a 67-Year-Old Patient. The Journal of Heart and Lung Transplantation. 2023. 42. 4
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Books (9)：
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レジデントノート 7月号
羊土社 2009
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血漿DNAサンプル中の上皮成長因子受容体変異により stage IIIB/IV 期非小細胞肺癌中国人患者における抗腫瘍効果が予測できる
アスカコーポレーション 2009
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Oncology Nursing (Vol.3, No.3)
先端医学社 2009
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CT ガイド下生検針の洗浄液を用いて NSCLC 患者からEGFR 遺伝子突然変異を検出する
アスカコーポレーション 2008
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末梢小型肺腺癌の多段階発症における連続的な分子変化
アスカコーポレーション 2008
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Lectures and oral presentations (146)：
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がんのエピジェネティクス異常
(日本肺癌学会学術集会)
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頭頚部癌治療歴を有する非小細胞肺がん患者に対する手術症例の検討
(日本肺癌学会学術集会)
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肺癌との鑑別が困難であった肺結節性リンパ過形成の1例?
(日本肺癌学会学術集会)
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定型カルチノイドを伴うびまん性特発性肺神経内分泌過形成の1例?
(日本肺癌学会学術集会)
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術前化学放射線療法後手術を行った局所進行肺癌術後再発症例の臨床経過
(日本肺癌学会学術集会)
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Professional career (1)：
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