Keita Komine

コミネケイタ | Keita Komine

Affiliation and department：

Research field (4)： Pharmaceuticals - chemistry and drug development , Synthetic organic chemistry , Bioorganic chemistry , Structural/physical organic chemistry

Research keywords (5)： natural product synthesis , 有機合成化学 , 天然物化学 , ラジカル反応 , タンデム反応

Research theme for competitive and other funds (4)：

2022 - 2025 新規三成分ラジカルカップリングの開発と創薬リード天然物の合成
2023 - 2024 非対称化を活用した画期的な不斉四級炭素構築法の開発と生物活性天然物合成への展開
2019 - 2021 Synthetic Studies on biologically active natural product having bicyclic core; Development of new method for the construction of bicyclo[3.3.1]nonane core
2016 - 2018 タンデムラジカル環化反応を基軸とする、Haliclonin Aの合成

Papers (13)：

Keita KOMINE, Yuta YAMAZAKI, Taiga IWANAGA, Hikaru SAKAGUCHI, Hayato FUKUDA, Jun Ishihara. Visible-Light-Induced Three-Component Radical Coupling of Selenocarbamates, Enones, and Allylstannanes with Diphenyl(2,4,6-trimethylbenzoyl)phosphine Oxide. Synlett. 2023
Norihiko Kawasaki, Yu Kikuoka, Keita Komine, Hayato Fukuda, Jun Ishihara. Concise Formal Synthesis on Solandelactone E Based on a Regioselective Cyclopropanation. HETEROCYCLES. 2022. 106. 2. 346-357
Komine, K., Kishimoto, S., Fukuda, H., Ishihara, J. Radical 4-exo cyclization of bicyclo[2.2.2]octene derivatives: Construction of tricyclo[3.3.1.0^2,7]nonane skeleton. Tetrahedron Letters. 2022. 105. 154056-154056
Keita Komine, Riki Ninomiya, Hayato Fukuda, Jun Ishihara. A Stereoselective Synthesis of Fused Carbocycles with a cis-1,2-Diol Moiety by Desymmetrization: SmI₂-Mediated Pinacol Coupling of meso-Cyclic 1,3-Diones. Chemical and Pharmaceutical Bulletin. 2022. 70. 1. 89-93
Tomohiro Tsutsumi, Moe Matsumoto, Hitomi Iwasaki, Kei Tomisawa, Keita Komine, Hayato Fukuda, Jacques Eustache, Rolf Jansen, Susumi Hatakeyama, Jun Ishihara. Total Synthesis of Thuggacin cmc-A and Its Structure Determination. Organic Letters. 2021. 23. 5208-5212

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MISC (2)：

小嶺敬太. 最難関天然物タキソールの効率的合成. 月刊化学 2022年2月号. 2022. 77. 2. 61-62
Keita KOMINE. Total Syntheses of Illicium Sesquiterpenes by Site-selective Desaturation. 2021. 57. 10. 940

Lectures and oral presentations (16)：

Formal Synthesis of (-)-Haliclonin A
(The 49th Congress of Heterocyclic Chemistry 2020)
Synthesis of Lajollamycin Family
(2019)
Formal Synthesis of Haliclonin A Using Tandem Radical Reaction
(27th International Society of Heterocyclic Chemistry Congress 2019)
Total Synthesis of Lajollamycin B
(2019)
タンデムラジカル環化反応を基盤としたハリクロニンAの合成研究
(反応と合成の進歩シンポジウム講演要旨集 2016)

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Education (3)：

2014 - 2017 Nagasaki University Graduate School of Biomedical Sciences
2012 - 2014 Nagasaki University Graduate School of Biomedical Sciences
2008 - 2012 Nagasaki University School of Pharmaceutical Sciences

Professional career (1)：

Doctor of Philosophy in Pharmaceutical Science in Pharmaceutical Sciences (Nagasaki University)

Work history (4)：

2018/10 - 現在 Nagasaki University Graduate School of Biomedical Sciences Assistant Professor
2017/04 - 2018/09 Baylor University Department of Chemistry & Biochemistry Postdoctoral Researcher
2017/04 - 2018/03 Nagasaki University Graduate School of Biomedical Sciences
2016/04 - 2018/03 日本学術振興会特別研究員(DC2)

Committee career (2)：

2022/08 - 現在天然物化学談話会世話人
2021/06 - 現在長薬同窓会本部役員編集幹事

Awards (10)：

2023/04 - 公益財団法人 UBE 学術振興財団第63回学術奨励賞
2019/09 - 第61回天然有機化合物討論会第61回天然有機化合物討論会奨励賞ラジョラマイシン類天然物の合成
2016/10 - 第7回大津会議アワードフェロー
2016/04 - 第 26 回万有福岡シンポジウム Best Discussion 賞
2016/03 - 平成 27 年度長崎大学学長賞

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Association Membership(s) (4)：

American Chemical Society , International Society of Heterocyclic Chemistry Congress , THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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