Research keywords (3)：
ACAT
, macrophage
, Atherosclerosis
Research theme for competitive and other funds (20)：
2021 - 2024 NAFLDおよび耐糖能異常における肝血管内皮細胞由来分枝アミノ酸の意義
2017 - 2020 Establishment of the strategy for treatment of lifestyle-related diseases by targeting macrophage mRNA splicing
2014 - 2017 Establishment of a novel therapeutic strategy for atherosclerosis utilizing a focal adhesion adaptor molecule
2014 - 2017 Regulation of macrophage foam cell formation and atherosclerosis by tissue-specific calpains
2012 - 2015 Roles of hydrogen peroxide-inducible clone-5 on vascular disease in chronic kidney disease
2011 - 2014 Regulation of macrophage foam cell formation and atherosclerotic diseases by cell adhesion signalling
2008 - 2011 Regulation of macrophage foam cell formation and atherosclerosis by novel regulatory peptides for cardiovascular system
2009 - 2010 Analysis of modified low-density lipoproteins in plasma of myocardial infarction
2006 - 2007 Mechanisms of Macrophage Foam Cell Formation and Hypertensive Complications Caused by Vasoactive Agents
2004 - 2006 Elucidation of the mechanisms for intracellular accumulation of cholesterol ester and its application to therapies.
2003 - 2005 Investigation of molecular mechanisms for common diseases caused by aging and oxidative stress and development of drug candidates aiming the molecular targets
2002 - 2004 Regulation of ACAT in multiple risk factor syndrome
2000 - 2002 Regulation of ACAT in diabetes and insuliln resistant
2000 - 2002 Development of novel anti-atheroscleroic agents
1998 - 2000 Regulation of ACAT, an enzyme involved in cholesterol esterification and foam cell formation in vascular walls
1999 - 2000 AGE Structures and their Biomedical Significance
1999 - 1999 分泌型スカベンジャー受容体、ガレクチン3のエンドサイトーシス機能の解析
1996 - 1997 Molecular Biology of Acyl-coenzyme A : cholesterol Acyltransferase
Takuro Miyazaki, Akira Miyazaki. Dysregulation of calpain proteolytic systems underlies degenerative vascular disorders. Journal of Atherosclerosis and Thrombosis. 2018. 25. 1. 1-15
Takuya Watanabe, Shigeko Arita, Yuji Shiraishi, Toshiaki Suguro, Tetsuo Sakai, Shigeki Hongo, Akira Miyazaki. Human Urotensin II Promotes Hypertension and Atherosclerotic Cardiovascular Diseases. CURRENT MEDICINAL CHEMISTRY. 2009. 16. 5. 550-563
Akira Miyazaki, Tomoko Kanome, Takuya Watanabe. Inhibitors of acyl-coenzyme A: Cholesterol acyltransferase. Current Drug Targets - Cardiovascular and Haematological Disorders. 2005. 5. 6. 463-469
T Jono, A Miyazaki, R Nagai, T Sawamura, T Kitamura, S Horiuchi. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). FEBS LETTERS. 2002. 511. 1-3. 170-174
WQ Zhu, H Sano, R Nagai, K Fukuhara, A Miyazaki, S Horiuchi. The role of galectin-3 in endocytosis of advanced glycation end products and modified low density lipoproteins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001. 280. 4. 1183-1188
1987 - 1991 Kumamoto University Kumamoto University
1978 - 1984 Kumamoto University School of Medicine School of Medicine
Professional career (1)：
医学博士 (熊本大学)
Work history (3)：
2002/11 - 現在 Showa University School of Medicine Department of Biochemistry Professor
1997/11 - 2002/10 Kumaomoto University School of Medicine Second Department of Biochemistry Associate Professor
1992/10 - 1997/10 Kumamoto University School of Medicine Second Department of Biochemistry Assistant Professor
Committee career (1)：
2013/04 - 2015/03 日本学術振興会 科研費審査委員
Awards (1)：
1994/06 - The second YIA from Japan Atherosclerosis Society Acetylated low density lipoprotein reduces its ligand activity for the scavenger receptor after interaction with reconstituted high density lipoprotein. (J Biol Chem. 1994;269(7):5264-5269.)
Association Membership(s) (5)：
日本血管生物医学会
, THE JAPANESE CANCER ASSOCIATION
, THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS
, JAPAN ATHEROSCLEROSIS SOCIETY
, THE JAPANESE BIOCHEMICAL SOCIETY
