Research field (5)：
Cell biology
, Metabolism and endocrinology
, Pharmaceuticals - health and biochemistry
, Pathobiochemistry
, Molecular biology
Research keywords (8)：
ケミカルバイオロジー
, Mitochondria
, Chemical screening
, マルチオミックス
, 神経変性疾患
, 加齢性疾患
, マクロファージ
, inflammation
Research theme for competitive and other funds (3)：
2022 - 2025 ナノ材料に対する細胞毒性を用いたNLRP3インフラマソーム炎症機構の解析
2014 - 2016 Dissecting the function and regulation of mitochondrial quality control system using multi-matrixed screening assay
2013 - 2014 Chemical dissection of mitochondrial function and inflammasome activation
Papers (18)：
Tran UT, Kitami T. Chemical screens for particle-induced macrophage death identifies kinase inhibitors of phagocytosis as targets for toxicity. Journal of nanobiotechnology. 2024
Tadashi Takeuchi, Tetsuya Kubota, Yumiko Nakanishi, Hiroshi Tsugawa, Wataru Suda, Andrew Tae-Jun Kwon, Junshi Yazaki, Kazutaka Ikeda, Shino Nemoto, Yoshiki Mochizuki, et al. Gut microbial carbohydrate metabolism contributes to insulin resistance. Nature. 2023. 621. 7978. 389-395
Paul Wilmes, Jean-Pierre Trezzi, Velma Aho, Christian Jäger, Sebastian Schade, Annette Janzen, Oskar Hickl, Benoit Kunath, Mélanie Thomas, Kristopher Schmit, et al. Artefactual source of 2-hydroxypyridine. 2023
Ami Kobayashi, Kotaro Azuma, Toshihiko Takeiwa, Toshimori Kitami, Kuniko Horie, Kazuhiro Ikeda, Satoshi Inoue. A FRET-based respirasome assembly screen identifies spleen tyrosine kinase as a target to improve muscle mitochondrial respiration and exercise performance in mice. Nature communications. 2023. 14. 1. 312-312
Paul Wilmes, Jean-Pierre Trezzi, Velma Aho, Christian Jäger, Sebastian Schade, Annette Janzen, Oskar Hickl, Benoit Kunath, Mélanie Thomas, Kristopher Schmit, et al. An archaeal compound as a driver of Parkinson’s disease pathogenesis. 2022
1995 - 1999 University of Notre Dame (U.S.A.) Department of Biological Sciences
Professional career (2)：
博士号(Ph.D. in Genetics) (Case Western Reserve University (U.S.A.))
Bachelor of Science (B.S.) (University of Notre Dame (U.S.A.))
Work history (5)：
2021/04 - 現在 理化学研究所 生命医科学研究センター チームリーダー
2020/04 - 2021/03 University of Luxembourg Luxembourg Centre for Systems Biomedicine (LCSB) Research Scientist
2013/04 - 2020/03 理化学研究所 生命医科学研究センター 上級研究員
2005 - 2013 Broad Institute of MIT & Harvard Metabolism Program Postdoc, Research Scientist I
1999 - 2005 Case Western Reserve University Department of Genetics Ph.D. student
Awards (1)：
2016/10 - The 13th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM) and the 16th Conference of Japanese Society of Mitochondrial Research & Medicine (J-mit) Poster Award
