Research theme for competitive and other funds (15):
2024 - 2028 Accelerating Aging Effects of Mitochondrial Metabolic Abnormalities in Human Aging Models
2024 - 2027 Multidisciplinary research aiming at improving the medical standards and better prognosis of progeroid syndromes
2024 - 2027 Development of Innovative Treatment for Werner Syndrome
2023 - 2026 Evidence creation and treatment development by accumulating long-term data based on the Werner Syndrome Registry
2023 - 2026 Multifaceted Analysis of Progeroid Syndromes for Understanding the Pathophysiology of Aging and Diseases
2023 - 2026 Exploring Novel Anti-Aging and Rejuvenation Mechanisms Through Human Aging Models
2022 - 2025 Unveiling the risk factors of ageing to promote healthy longevity
2022 - 2024 Deciphering the pathogenesis of Werner syndrome using a non-human primate model and patient-specific iPS cells
2022 - 2024 Development of Innovative Treatment for Werner Syndrome
2022 - 2024 Elucidation of the relationship between aberrant nucleic acid metabolism and accelerated aging in Werner syndrome
2021 - 2024 Nationwide study to improve the quality of medical care and patient QOL through the accumulation of evidence on progeroid syndromes
2020 - 2023 The role of Pericyte Senescence in Diabetic Complications
2021 - 2022 Effects of a newly discovered mitochondrial toxin on aging and its universality as an aging biomarker
2020 - 2022 Deciphering the aging mechanism directed by exosomes in the adult progeria Werner syndrome
2019 - 2021 The effects of mechanical stress on cellular senescence in adult progeria Werner syndrome
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Papers (47):
Kazuto Aono, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Yukari Maeda, Hisaya Kato, Yoshiro Maezawa, Makoto Miyabayashi, Mai Ishikawa, Akiko Sekiguchi, et al. Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry. Aging. 2024. 16
Kazuto Aono, Yoshiro Maezawa, Hisaya Kato, Hiyori Kaneko, Yoshitaka Kubota, Toshibumi Taniguchi, Toshiyuki Oshitari, Sei-Ichiro Motegi, Hironori Nakagami, Akira Taniguchi, et al. Recommendations for cancer screening and surveillance in patients with Werner syndrome. Geriatrics & Gerontology International. 2024
Sudip Kumar Paul, Motohiko Oshima, Ashwini Patil, Masamitsu Sone, Hisaya Kato, Yoshiro Maezawa, Hiyori Kaneko, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, et al. Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model. Nature communications. 2024. 15. 1. 4772-4772
Clinical and Basic Biology of Werner Syndrome, the Model Disease of Human Aging. In: Mori, N. (eds) Aging Mechanisms II .
Springer, Singapore. 2022 ISBN:9789811679766
A clinical trial of nicotinamide riboside for patients with Werner syndrome: EMPOWER
(Third Meeting of the Anglo-Japanese Global Partnership Award Group 2025)
Aging research and therapeutic development based on the progeroid Werner syndrome
(SPC (Science Pioneers Consortium) 2024 2024)
The role of GLP-1 receptor agonists in diabetes treatment
(GLP-1 Web seminar 2024)
Translational Research in Werner Syndrome as a Model of Progeria: Including Implications for Diabetes Treatment
(13th Clinical & Basic Research Forum 2024)
Innovative Treatments for Werner Syndrome Using NAD+ Precursors and Development of Nucleic Acid Therapeutics via Exon Skipping
(The 66th Annual Meeting of the Japan Geriatrics Society 2024)
2015 - 2019 Chiba University Graduate School of Medical and Pharmaceutical Sciences, Ph.D. Program Graduate student
2015 - 2016 Hiroshima University Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences Visiting graduate student
2005 - 2011 Chiba University School of Medicine Undergraduate student
Professional career (2):
Ph.D. (Chiba University Graduate School of Medical and Pharmaceutical Sciences)
M.D. (Chiba University School of Medicine)
Work history (3):
2020/06 - 現在 Chiba University Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine Assistant Professor
2019/04 - 2020/05 Chiba University Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine Assistant Professor
2015/04 - 2019/03 Chiba University Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine Clinical Fellow
Committee career (1):
2023/06 - 現在 The Japan Geriatrics Society Delegate
Awards (4):
2024/12 - Science Pioneers Consortium & Taisho Pharmaceutical Co., Ltd. Young Investigator Taisho Award (YITA)
2022/06 - The Japan Geriatrics Society The 4th Japan Geriatrics Society Young Investigator Award
2022/01 - Japan Intractable Diseases (Nanbyo) Research Foundation FY2021 Medical Research Encouragement Grant
2018/02 - The RECQ Organizing Committee & Japan Intractable Diseases (Nanbyo) Research Foundation Poster Award
Association Membership(s) (4):
The Japan Endocrine Society
, The Japan Geriatrics Society
, The Japan Diabetes Society
, The Japanese Society of Internal Medicine