Yoshioka Hiromasa

Affiliation and department：
Job title： Special Postdoctoral Researcher

Research field (5)： Applied biochemistry , Applied molecular and cellular biology , Pharmaceuticals - chemistry and drug development , Chemical biology , Bioorganic chemistry

Research theme for competitive and other funds (4)：

2024 - 2027 生体内で安定な人工金属触媒の開発と、組織特異的SQLE分解誘導剤合成への応用
2023 - 2026 組織選択的なタンパク質安定性制御方法の開発
2022 - 2024 Development of robust catalysts applicable in-blood synthesis and their application to tissue-specific drug synthesis.
2018 - 2020 Development of small molecules that modulate cholesterol homeostasis via ligand-mediated stabilization/destabilization.

Papers (13)：

Takatsugu Kasahara, Tsung-Che Chang, Hiromasa Yoshioka, Sayaka Urano, Yasuko Egawa, Michiko Inoue, Tsuyoshi Tahara, Koji Morimoto, Ambara R. Pradipta, Katsunori Tanaka. Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein. Chemical Science. 2024
Igor Nasibullin, Hiromasa Yoshioka, Akari Mukaimine, Akiko Nakamura, Yuriko Kusakari, Tsung-Che Chang, Katsunori Tanaka. Catalytic olefin metathesis in blood. Chemical Science. 2023
Kawamura K, Yoshioka H, Sato C, Yajima T, Furuyama Y, Kuramochi K, Ohgane K. Fine-tuning of nitrogen-containing bisphosphonate esters that potently induce degradation of HMG-CoA reductase. Bioorganic & medicinal chemistry. 2022. 78
Hiromasa Yoshioka, Tatsuro Kawamura, Makoto Muroi, Yasumitsu Kondoh, Kaori Honda, Makoto Kawatani, Harumi Aono, Herbert Waldmann, Nobumoto Watanabe, Hiroyuki Osada. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1). ACS Chemical Biology. 2022. 17. 2. 483-491
Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane. Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs. PLOS ONE. 2020. 15. 12. e0243746

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MISC (4)：

吉岡広大. BOOKS紹介実験医学別冊論文図表を読む作法はじめて出会う実験&解析法も正しく解釈!生命科学・医学論文をスラスラ読むためのFigure事典. MEDCHEM NEWS. 2024. 34. 2. 102-102
Introducing Our Authors. ACS Chemical Biology. 2022. 17. 3. 493-494
Hiromasa Yoshioka. コレステロール生合成の新たな制御ポイント. 生化学. 2021. 93. 1. 147-151
Hiromasa Yoshioka. 細胞内で標的選択的に共有結合を形成するプロドラッグ. ファルマシア. 2021. 57. 2. 147-147

Lectures and oral presentations (27)：

がん細胞内で起こる[4+4]付加環化反応の生物学的な意義の解明に向けて
(日本化学会第104春季年会 2024)
フェロトーシスを制御する低分子化合物の探索
(第96回日本生化学会大会 2023)
がん細胞内で起こる[4+4]付加環化反応の意義の解明に向けて
(第13回 CSJ化学フェスタ2023 2023)
6-アザ-アルテミシニンのエナンチオ分岐合成およびケミカルプローブを用いた制がん機構研究
(2023年度若手支援技術講習会 2023)
Targeted therapy for KRAS-mutant cancer using glycosylated artificial metalloenzymes via therapeutic in vivo synthetic chemistry
(2023)

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Works (1)：

Quantification of Gel Bands by an Image J Macro, Band/Peak Quantification Tool
Kenji Ohgane, Hiromasa Yoshioka 2019 -

Education (3)：

2015 - 2020 The University of Tokyo Graduate School of Pharmaceutical Sciences
2011 - 2015 Yokohama City University
2008 - 2011 東京都市大学附属高等学校

Professional career (1)：

博士(薬科学) (東京大学)

Work history (6)：

2024/04 - 現在 RIKEN Special Postdoctoral Researcher
2021/10 - 現在 Ochanomizu University Faculty of Science
2022/04 - 2024/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
2022/04 - 2024/03 RIKEN Biofunctional Synthetic Chemistry Laboratory Postdoctoral Researcher
2020/04 - 2022/03 RIKEN CSRS Chemical Biology research group post-doctoral researcher

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Association Membership(s) (3)：

JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE JAPANESE BIOCHEMICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN

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