Research field (2)：
Chemical biology
, Biochemistry
Research keywords (4)：
Chemical biology
, Nucleic acids chemistry
, Drug delivery system
, DNA
Research theme for competitive and other funds (7)：
2023 - 2024 Development of novel nucleic acid medicines utilizing hydrophobic intereactions with Toll-like receptors
2021 - 2024 Development of multivalent and multifunctional nucleic acids medicines using branching structures
2021 - Development of highly structured nucleic acids medicines with less side effects
2020 - 2021 Development of drug delivery system using multifunctional DNA micelles
2018 - 2019 Development of the fluorescence-based methods to monitor gene regulation processes in nucleic acids
2018 - 2018 Monitoring and elucidating gene regulation process by structural change of DNA
2015 - 2018 Development of the new class of the DNA-binding pyrrole-imidazole polyamides
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Papers (25)：
Deepak Karna, Lin Liang, Grinsun Sharma, Shankar Mandal, Sefan Asamitsu, Yusuke Kawamoto, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama, Hanbin Mao. Modulation of dynamic DNA G-quadruplex structures in the hTERT promoter region by ligands. Nucleic Acids Research. 2024
Yusuke Kawamoto, You Wu, Soyoung Park, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Yoshinobu Takakura. Multivalent dendritic DNA aptamer molecules for the enhancement of therapeutic effects. Chemical Communications. 2024. 60. 49. 6256-6259
Keisuke Umemura, Yusuke Kawamoto, Yuki Takahashi, Yoshinobu Takakura. Development of a Cytosolic DNA Sensor Agonist Using GALA Peptide-Conjugated DNA and Long Single-Stranded DNA. Molecular Pharmaceutics. 2024. 21. 3. 1204-1213
Wakana Oda, Keisuke Umemura, Koichi Ito, Yusuke Kawamoto, Yuki Takahashi, Yoshinobu Takakura. Development of potent unmethylated CpG DNA hydrogel by introducing i-motifs into long single-stranded DNA. International Journal of Pharmaceutics. 2023. 646. 123438-123438
Yusuke Kawamoto, You Wu, Yuki Takahashi, Yoshinobu Takakura. Development of Nucleic Acid Medicines Based on Chemical Technology. Advanced Drug Delivery Reviews. 2023. 199. 114872
Yuki Mochida, Yusuke Kawamoto. Tips for your DDS research High Performance Liquid Chromatography. Drug Delivery System. 2023. 38. 4. 329-333
Yusuke Kawamoto. Drug Delivery System to Imptove Functions of Middle Molecules. Drug Delivery System. 2023. 38. 2. 178-179
Books (1)：
Synthesis and Biological Evaluation of Pyrrole-Imidazole Polyamide Probes for Visualization of Telomeres
Springer 2019
Lectures and oral presentations (26)：
Synthesis and Evaluation of Dendritic Oligonucleotides for Therapeutics
(The 8th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan 2023)
Development of Dendritic Multivalent Oligonucleotides for Therapeutics
(The 143rd Annual Meeting of the Pharmaceutical Society of Japan 2023)
Development of Dendritic Multivalent Oligonucleotides for Therapeutics
(The 143rd Annual Meeting of the Pharmaceutical Society of Japan 2023)
Development of the Dendritic Oligonucleotides for Therapeutics
(The 7th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan 2022)
Immunostimulatory Activity of DNA Dendrimers
(The 48th International Symposium on Nucleic Acids Chemistry 2021)
2013 - 2018 Kyoto University Graduate School of Science Department of Chemistry
2009 - 2013 Kyoto University Faculty of Science
Professional career (1)：
Ph.D. in Science (Kyoto University)
Work history (4)：
2019/10 - 2024/09 Kyoto University Graduate School of Pharmaceutical Sciences Assistant Professor
2018/07 - 2019/09 Japan Society for the Promotion of Science JSPS Overseas Research Fellow
2018/04 - 2019/09 University of California, San Diego Department of Chemistry and Biochemistry Postdoctoral Fellow
2015/04 - 2018/03 Japan Society for the Promotion of Science JSPS Research Fellow (DC1)
Awards (3)：
2018/09 - Springer Nature Springer Theses Award
2018/08 - The International Society of Nucleosides, Nucleotides & Nucleic Acids XXIII International Roundtable of Nucleosides, Nucleotides And Nucleic Acids (IRT 2018) Holy Poster Prize
2017/03 - Student Presentation Award 2017 at the 97th CSJ Annual Meeting
Association Membership(s) (5)：
日本DDS学会
, 日本核酸医薬学会
, The Japan Society of Nucleic Acids Shemistry
, The Pharmaceutical Society of Japan
, THE CHEMICAL SOCIETY OF JAPAN
