2020 - 2024 Fundamental research on cardiac nanophysiology for clinical application
2018 - 2022 In vivo nano-analysis of cardiac excitation-contraction coupling.
2015 - 2018 Elucidation of cardiac regulatory mechanisms by in vivo nano-imaging
2014 - 2018 Development of core technologies for heart diagnostic imaging apparatus based on nanoanalysis
2016 - ラット摘出灌流心臓における心筋収縮動態の高速高精度解析
2011 - 2016 Elucidation of the heart's functions by in vivo nano-imaging
2011 - 2015 Analysis of cell dynamics using intravital nano-imaging.
2011 - 2015 Elucidation of cardiac excitation-contraction coupling by in vivo nano-imaging
2011 - 2014 In vivo ナノイメージングによる心疾患の病態解析
2011 - 2013 Development of molecular imaging technologies for the early diagnosis of heart disease
2010 - In vivo心筋ナノイメージングを用いた心筋収縮・弛緩の分子メカニズム解析
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Papers (23):
Tomohiro Nakanishi, Kotaro Oyama, Hiroyuki Tanaka, Fuyu Kobirumaki-Shimozawa, Shuya Ishii, Takako Terui, Shin’ichi Ishiwata, Norio Fukuda. Effects of omecamtiv mecarbil on the contractile properties of skinned porcine left atrial and ventricular muscles. Frontiers in Physiology. 2022. 13
Fuyu Kobirumaki-Shimozawa, Togo Shimozawa, Kotaro Oyama, Shunsuke Baba, Jia Li, Tomohiro Nakanishi, Takako Terui, William E Louch, Shin'ichi Ishiwata, Norio Fukuda. Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart. The Journal of general physiology. 2021. 153. 11
Fuyu Kobirumaki-Shimozawa, Tomohiro Nakanishi, Togo Shimozawa, Takako Terui, Kotaro Oyama, Jia Li, William Louch, Shin'ichi Ishiwata, Norio Fukuda. Real-time in vivo imaging of mouse left ventricle reveals fluctuating movements of the intercalated discs. Nanomaterials. 2020. 10. 3. E532
Shuya Ishii, Kotaro Oyama, Tomomi Arai, Hideki Itoh, Seine A Shintani, Madoka Suzuki, Fuyu Kobirumaki-Shimozawa, Takako Terui, Norio Fukuda, Shin'ichi Ishiwata. Microscopic heat pulses activate cardiac thin filaments. The Journal of general physiology. 2019. 151. 6. 860-869
Fuyu Kobirumaki-Shimozawa, Kotaro Oyama, Akari Mizuno, Takako Terui, Togo Shimozawa, Takashi Ohki, Shin'ichi Ishiwata, Norio Fukuda. Real-Time Imaging of Sarcomere Dynamics in the Mouse Heart In Vivo. BIOPHYSICAL JOURNAL. 2014. 106. 2. 645A-646A
Teruyuki Fujii, Takako Terui, Norio Fukuda. Effect of intravenous anesthetic propofol on Ca2+-activated force in skinned porcine left ventricular muscle. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S274-S274
Thin filament-based regulation of length-dependent activation in skinned porcine ventricular muscle.
(36th International Congress of Physiological Sciences 2009)
Role of thin filament cooperative activation in length-dependent activation in skinned porcine ventricular muscle.
(53rd Biophysical Society Annual Meeting 2009)