Rchr
J-GLOBAL ID：201901011405644433
Update date: Sep. 05, 2024
Tsunaka Yasuo
ツナカ ヤスオ | Tsunaka Yasuo
Affiliation and department：
Job title：
Specially Appointed Associate Professor
Research field (5)：
Applied biochemistry
, Pharmaceuticals - analytical and physicochemistry
, Functional biochemistry
, Molecular biology
, Structural biochemistry
Research keywords (17)：
Purification of virus vector
, Purification of protein complexes
, Column Chromatography
, Viral Vector manufacturing for gene therapy
, FACT
, Synergistic structural biology
, NMR
, Cryo-electron microscopy
, Intrinsically disordered protein
, X-ray crystal structure analysis
, Histone
, Chromatin
, Structural Biology
, Epigenetics
, Nucleosome
, Histone chaperone
, Chromatin remodeling
Research theme for competitive and other funds (6)：
Papers (33)：
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Sereirath Soth, Mikako Takakura, Masahiro Suekawa, Takayuki Onishi, Kiichi Hirohata, Tamami Hashimoto, Takahiro Maruno, Mitsuko Fukuhara, Yasuo Tsunaka, Tetsuo Torisu, et al. Quantification of full and empty particles of adeno-associated virus vectors via a novel dual fluorescence-linked immunosorbent assay. Molecular therapy. Methods & clinical development. 2024. 32. 3. 101291-101291
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Tomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama. Higher-Order Structure of Adeno-Associated Virus Serotype 8 by Hydrogen/Deuterium Exchange Mass Spectrometry. Viruses. 2024. 16. 4. 585
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Yuki Yamaguchi, Kentaro Ishii, Sachiko Koizumi, Hiroaki Sakaue, Takahiro Maruno, Mitsuko Fukuhara, Risa Shibuya, Yasuo Tsunaka, Aoba Matsushita, Karin Bandoh, et al. Glycosylation of recombinant adeno-associated virus serotype 6. Molecular Therapy - Methods & Clinical Development. 2024. 32. 2. 101256-101256
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Haruka Nishiumi, Kiichi Hirohata, Mitsuko Fukuhara, Aoba Matsushita, Yasuo Tsunaka, Mark Allen Vergara Rocafort, Takahiro Maruno, Tetsuo Torisu, Susumu Uchiyama. Combined 100 keV cryo-electron microscopy and image analysis methods to characterize the wider adeno-associated viral products. Journal of pharmaceutical sciences. 2024
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Hideaki Ohtomo, Tsutomu Yamane, Takashi Oda, Noriyuki Kodera, Jun-Ichi Kurita, Yasuo Tsunaka, Romain Amyot, Mitsunori Ikeguchi, Yoshifumi Nishimura. Dynamic Solution Structures of Whole Human NAP1 Dimer Bound to One and Two Histone H2A-H2B Heterodimers Obtained by Integrative Methods. Journal of Molecular Biology. 2023. 435. 15. 168189-168189
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MISC (39)：
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Structural characterization of dynamic changes of histone H3 N-tails through FACT using synergistic structural biology approaches. 2021
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Yasuo Tsunaka, Hideaki Ohtomo, Kosuke Morikawa, Yoshifumi Nishimura. Dynamic behavior of histone H3 N-tails in chromatin remodeling by FACT. The 14th Annual Meeting of the Japanese Society for Epigenetics. 2021
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Yasuo Tsunaka, Hideaki Ohtomo, Kosuke Morikawa, Yoshifumi Nishimura. NMR analysis for dynamic behavior of histone H3 N-tails invisible in the EM structure of nucleosomal complex with FACT. 2020. 43nd. ROMBUNNO.1P-0049 (WEB ONLY)
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津中康央, 真柳浩太, 七種和美, 宮崎直幸, 明石知子, 岩崎憲治, 西村善文, 森川耿右. FACTによって引き起こされるヘキサゾーム構造の電子顕微鏡解析. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd. ROMBUNNO.3P-0131 (WEB ONLY)
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Structural snapshots of nucleosome reorganization mechanism by human FACT. 2019
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Lectures and oral presentations (14)：
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クライオ電顕構造とNMR解析を組み合わせてFACTを介したヒストンテイルの動的構造変化にせまる
(第39回染色体ワークショップ・ 第20回核ダイナミクス研究会 2021)
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Structural characterization for dynamic changes of histone H2A and H2B tails by FACT
(The 44th Annual Meeting of the Molecular Biology Society of Japan 2021)
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FACT acts as a modulator for dynamic behavior of nucleosome, thereby altering the accessibility.
(The 94th Annual Meeting of the Japanese Biochemical Society 2021)
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Structural characterization of dynamic changes of histone H3 N-tails through FACT using synergistic structural biology approaches
(2021)
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Dynamic behavior of histone H3 N-tails in chromatin remodeling by FACT
(The 14th Annual Meeting of the Japanese Society for Epigenetics 2021)
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Education (3)：
- 2001 - 2004 Osaka University Graduate School of Engineering
- 1999 - 2001 Osaka University Graduate School of Engineering
- 1995 - 1999 Osaka University School of Engineering
Professional career (1)：
Work history (7)：
Awards (1)：
- 2016/12 - The 39th annual meeting of the Molecular Biology Society of Japan Excellent poster award Molecular mechanism for chromatin remodeling by FACT
Association Membership(s) (4)：
PROTEIN SCIENCE SOCIETY OF JAPAN
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY
, The Japanese Society for Epigenetics
