Sakai Yuji

サカイユウジ | Sakai Yuji

Affiliation and department：
Job title： Program-Specific Associate Professor
Other affiliations (2)：

The University of Tokyo Graduate School of Medicine Visiting Researcher
RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program Visiting Researcher

Research field (4)： Cell biology , Biophysics , Genetics , Bio-, chemical, and soft-matter physics

Research keywords (8)： Theoretical Biology , Biophysics , Cell Biology , Molecular Biology , Soft Matter Physics , Organelle , Chromosome , Autophagy

Research theme for competitive and other funds (8)：

2023 - 2027 Theoretical study of autophagic membrane dynamics
2023 - 2025 Theoretical study of intracellular degradation mechanisms
2023 - 2024 Elucidation of intracellular lipid transfer mechanism using molecular dynamics simulations
2020 - 2023 Theoretical study for mitotic chromosome assembly
2018 - 2020 Theoretical study of autophagy dynamics

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Papers (41)：

Yuji Sakai, Satoru Takahashi, Ikuko Koyama-Honda, Chieko Saito, Noboru Mizushima. Experimental determination and mathematical modeling of standard shapes of forming autophagosomes. Nature communications. 2024. 15. 1. 91-91
Tetsuya Kotani, Yuji Sakai, Hiromi Kirisako, Chika Kakuta, Soichiro Kakuta, Yoshinori Ohsumi, Hitoshi Nakatogawa. A mechanism that ensures non-selective cytoplasm degradation by autophagy. Nature Communications. 2023. 14. 1. 5815-5815
Zi Yang, Saori R. Yoshii, Yuji Sakai, Haruka Chino, Roland L. Knorr, Noboru Mizushima. Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates. 2023
Saori Shinoda, Yuji Sakai, Takahide Matsui, Masaaki Uematsu, Ikuko Koyama-Honda, Jun-ichi Sakamaki, Hayashi Yamamoto, Noboru Mizushima. Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation. eLife. 2023
Yuji SAKAI. Mathematical Model of Membrane Deformation Dynamics in Autophagosome Formation. Seibutsu Butsuri. 2022. 62. 1. 50-52

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MISC (58)：

Yuji Sakai. Mathematical Model of Membrane Deformation Dynamics in Autophagosome Formation. 生物物理(Web). 2022. 62. 1
Yuji Sakai, Satoru Takahashi, Ikuko Koyama-Honda, Chieko Saito, Noboru Mizushima. Modeling membrane morphogenesis in autophagosome formation. 日本数理生物学会年会(Web). 2022. 32nd
境祐二. Modeling mitotic chromosome organization and segregation mediated by condensins. 月刊細胞. 2022. 54. 11
境祐二. オートファゴソーム形成の膜変形ダイナミクスの数理モデル. 生物物理. 2022. 62. 1. 50-52
小山郁子[本田], 境祐二, 立川正志, 田村律人, 水島昇. 神経系におけるオルガネラコミュニケーションとダイナミクスオートファゴソーム膜の形態と物理モデル. 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [1S06e-05]

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Lectures and oral presentations (4)：

Experimental determination and theoretical model of standard shapes of forming autophagosomes
(ICBP 2023 - International Conference on Biological Physics 2023)
Molecular dynamics of autophagosomal lipid transfer Atg2
(CCP2023 - 34th IUPAP Conference on Computational Physics 2023)
オートファゴソーム形成の数理モデル
(ERATO 水島細胞内分解ダイナミクスプロジェクト最終シンポジウム「細胞内分解研究の未来を拓く」 2023)
分裂期染色体形成の数理モデル
(第75回日本細胞生物学会大会 2023)

Education (1)：

Professional career (1)：

Work history (7)：

2022/04 - 現在 Kyoto University Institute for Frontier Life and Medical Sciences Program-Specific Associate Professor
2017/04 - 2022/03 The University of Tokyo Graduate School of Medicine Assistant Professor
2014/04 - 2022/03 Seikei University Faculty of Science and Technology Lecturer (part-time)
2015/04 - 2017/03 RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program
2014/04 - 2016/03 RIKEN

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