Sakai Yuji

サカイユウジ | Sakai Yuji

Affiliation and department：
Job title： Specially Appointed Associate Professor
Other affiliations (2)：

The University of Tokyo Graduate School of Medicine Visiting Researcher
RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program Visiting Researcher

Research field (4)： Cell biology , Biophysics , Genetics , Bio-, chemical, and soft-matter physics

Research keywords (8)： Theoretical Biology , Biophysics , Cell Biology , Molecular Biology , Soft Matter Physics , Organelle , Chromosome , Autophagy

Research theme for competitive and other funds (9)：

2024 - 2028 フェリチン液滴オートファジーの分子メカニズムの総合的理解
2023 - 2027 Theoretical study of autophagic membrane dynamics
2023 - 2025 Theoretical study of intracellular degradation mechanisms
2023 - 2024 Elucidation of intracellular lipid transfer mechanism using molecular dynamics simulations
2020 - 2023 Theoretical study for mitotic chromosome assembly

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Papers (47)：

Zi Yang, Saori R Yoshii, Yuji Sakai, Jing Zhang, Haruka Chino, Roland L Knorr, Noboru Mizushima. Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates. The EMBO Journal. 2024
Kayo Hibino, Yuji Sakai, Sachiko Tamura, Masatoshi Takagi, Katsuhiko Minami, Toyoaki Natsume, Masa A Shimazoe, Masato T Kanemaki, Naoko Imamoto, Kazuhiro Maeshima. Single-nucleosome imaging unveils that condensins and nucleosome-nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes. Nature communications. 2024. 15. 1. 7152-7152
Yuji Sakai, Satoru Takahashi, Ikuko Koyama-Honda, Chieko Saito, Noboru Mizushima. Experimental determination and mathematical modeling of standard shapes of forming autophagosomes. Nature communications. 2024. 15. 1. 91-91
Tetsuya Kotani, Yuji Sakai, Hiromi Kirisako, Chika Kakuta, Soichiro Kakuta, Yoshinori Ohsumi, Hitoshi Nakatogawa. A mechanism that ensures non-selective cytoplasm degradation by autophagy. Nature Communications. 2023. 14. 1. 5815-5815
Saori Shinoda, Yuji Sakai, Takahide Matsui, Masaaki Uematsu, Ikuko Koyama-Honda, Jun-ichi Sakamaki, Hayashi Yamamoto, Noboru Mizushima. Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation. eLife. 2023

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MISC (59)：

堀江(川俣)朋子, 境祐二, 野田展生, 大隅良典. 液胞で働くメンブレンアーゼをロック/アンロックするために. 脂質生化学研究. 2024. 66
山本渓一, 境祐二, 望月敦史. Study of cone mosaic formation in fish retinas using a mathematical model. 日本数理生物学会年会(Web). 2023. 2023
小山(本田)郁子, 境祐二, 高橋暁, 高橋暁, 齊藤知恵子, 立川正志, 水島昇. マクロオートファジーにおける細胞質ゾーニング. 日本生化学会大会(Web). 2023. 96th
境祐二, 境祐二, 高橋暁, 本田郁子, 齊藤知恵子, 水島昇. 未閉鎖オートファゴソームの標準形態の実験的決定と理論モデル. 日本生化学会大会(Web). 2023. 96th
日比野佳代, 日比野佳代, 日比野佳代, 境祐二, 鐘巻将人, 鐘巻将人, 前島一博, 前島一博. ヒト染色体凝縮過程の単一ヌクレオソームイメージング. 日本遺伝学会大会プログラム・予稿集. 2022. 94th (CD-ROM)

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Lectures and oral presentations (75)：

Modeling mitotic chromatin dynamics
(遺伝研研究会「第2回ゲノムモデリング研究会」 2024)
Experimental determination and theoretical model of standard shapes of forming autophagosomes
(ICBP 2023 - International Conference on Biological Physics 2023)
Molecular dynamics of autophagosomal lipid transfer Atg2
(CCP2023 - 34th IUPAP Conference on Computational Physics 2023)
オートファゴソーム形成の数理モデル
(ERATO 水島細胞内分解ダイナミクスプロジェクト最終シンポジウム「細胞内分解研究の未来を拓く」 2023)
分裂期染色体形成の数理モデル
(第75回日本細胞生物学会大会 2023)

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Education (1)：

Professional career (1)：

Work history (8)：

2024/05 - 現在 Yokohama City University School of Science Graduate School of Nanobioscience Department of Materials System Science Specially Appointed Associate Professor
2022/04 - 2024/03 Kyoto University Institute for Frontier Life and Medical Sciences Program-Specific Associate Professor
2017/04 - 2022/03 The University of Tokyo Graduate School of Medicine Assistant Professor
2014/04 - 2022/03 Seikei University Faculty of Science and Technology Lecturer (part-time)
2015/04 - 2017/03 RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program

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