Hojo Hironori

ホウジョウヒロノリ | Hojo Hironori

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://grn.tokyo/med/ , https://grn.tokyo/med/en/

Research field (1)： Biomedical engineering

Research keywords (5)： Skeletal development and regeneration , Enhancer landscape , Omics analysis , Human Pluripotent Stem Cells , CRISPR technology

Research theme for competitive and other funds (27)：

2022 - 2025 Study on the role of sulfur respiration in homeostasis and disruption of the skeletal system under hypoxic conditions
2022 - 2025 Evaluation of properties by epigenome analysis for human umbilical cord-derived stromal cells and research for bone regenerative medicine
2022 - 2025 Sp7-Dlx相互作用の顎顔面骨再生における機能の解明と歯科矯正治療への応用
2021 - 2025 ヒト骨発生機構の理解に基づく組織再生研究基盤の構築
2021 - 2025 Comprehensive understanding of the enhancer cluster regulating the expression of Indian hedgehog in the skeletal system

2022 - 2024 Development of effective tissue regeneration method based on single cell genomics of neural crest derived cell

2021 - 2024 一細胞CRISPRスクリーニング法を駆使した機能的GWAS-SNP検出法の確立

2021 - 2024 Prohibitinの軟骨分化機能解析とその知見を用いた変形性関節症薬の探索

2020 - 2024 骨発生・骨修復におけるエピゲノムダイナミクスの比較解析と骨再生への応用

2021 - 2023 Investigation of the mechanism of actions of the helioxanthin-derivative and its application as a multi-kinase inhibitor

2021 - 2023 組織リモデリングの理解に基づく骨再生法の開発

2018 - 2021 In vitro modeling of human bone metabolism using pluripotent stem cell-derived bone organoids

2018 - 2021 Development of functional enhancer screening system by integrating genome editing technology with single-cell RNA-seq

2018 - 2021 Elucidation of stem cell signal using genome structure as an index and application to bone regenerative medicine

2017 - 2021 Fundamental study of bone regeneration with site-specific epigenome editing

2016 - 2021 Development of 4-dimensional scaffold system that integrates signaling factors and 3-dimensional structural biomaterials

2017 - 2020 Identification of regulatory factors contributing to migration or recruitment of osteoblast progenitors by genome-wide approach and the application for bone repair

2017 - 2020 Understanding of Runx2-mediated hierarichical gene regulatory network in bone formation and application of the network for bone regeneration

2017 - 2020 Identification of osteoclast-supporting cells and the investigation of the in vivo functions of the cells using mouse ES cells

2017 - 2019 転写因子Runx2を中心とする階層的骨形成転写ネットワークの解明とその応用

2015 - 2018 Identification of the molecular network regulating movement of Hedgehog proteins on cell surface during skeletal development

2014 - 2018 Dynamics of epigenome and transcription during the Hedgehog signaling-mediated specification of skeletal cells

2018 - ゲノム編集技術と一細胞RNA-seq解析を融合した機能的エンハンサー探索法の開発

2011 - 2013 新規器官培養系を用いた骨軟骨前駆細胞の分化決定制御機構の解明と骨再生療法への応用

2011 - 新規器官培養系を用いた骨軟骨前駆細胞の分化決定制御機構の解明と骨再生療法への応用

2008 - 2010 バイオ・ナノ融合テクノロジーを基盤とした新規的な骨・軟骨誘導剤の開発

2008 - バイオ・ナノ融合テクノロジーを基盤とした新規的な骨・軟骨誘導剤の開発

Show all

Papers (74)：

Dahlia Eldeeb, Yuki Ikeda, Hironori Hojo, Shinsuke Ohba. Unraveling the hidden complexity: Exploring dental tissues through single-cell transcriptional profiling. Regenerative Therapy. 2024
Shant Nepal, Jinyan Si, Shohei Ishikawa, Masaki Nishikawa, Yasuyuki Sakai, Aya M. Akimoto, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Takamasa Sakai, et al. Injectable phase-separated tetra-armed poly(ethylene glycol) hydrogel scaffold allows sustained release of growth factors to enhance the repair of critical bone defects. Regenerative Therapy. 2024. 25. 24-34
Qing Jiang, Xin Qin, Takeshi Moriishi, Ryo Fukuyama, Shinichi Katsumata, Hiroshi Matsuzaki, Hisato Komori, Yuki Matsuo, Chiharu Sakane, Kosei Ito, et al. Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23. International Journal of Molecular Sciences. 2024
Yuki Ikeda, Shoichiro Tani, Takeshi Moriishi, Aiko Kuroda, Yuki Matsuo, Naoya Saeki, Chizuko Inui-Yamamoto, Makoto Abe, Takashi Maeda, David W. Rowe, et al. Modeling of intramembranous ossification using human pluripotent stem cell-derived paraxial mesoderm derivatives. Regenerative Therapy. 2023. 24. 536-546
Hiroyuki Okada, Ung-Il Chung, Hironori Hojo. Practical Compass of Single-Cell RNA-Seq Analysis. Current osteoporosis reports. 2023

ｍore...

MISC (46)：

行森茜, 田中準一, 北條宏徳, 安原理佳, 鯨岡聡子, 石田尚子, 大庭伸介, 美島健二. ChIP-seqを用いた胎生期マウス顎下腺組織におけるFoxc1による発現制御遺伝子の網羅的解析. 日本病理学会会誌. 2023. 112. 1. 292-292
山下裕輔, 金英一, 中村唱乃, 粟田ちひろ, 金武祚, 北浦義昭, 鄭雄一, 北條宏徳, 大庭伸介. 骨形成促進作用を有する卵黄由来ペプチドVNPEの発見(その1 ペプチド探索と体内動態). 日本栄養・食糧学会大会講演要旨集. 2023. 77回. 288-288
金英一, 山下裕輔, 中村唱乃, 粟田ちひろ, 金武祚, 北浦義昭, 鄭雄一, 北條宏徳, 大庭伸介. 骨形成促進作用を有する卵黄由来ペプチドVNPEの発現(その2 モデル動物における生理活性評価). 日本栄養・食糧学会大会講演要旨集. 2023. 77回. 289-289
永田向生, 齋藤琢, 北條宏徳, 矢野文子, 岡田寛之, 大庭伸介, 鄭雄一, 田中栄. Runx2とRunx3は手術誘導された変形性関節症において関節軟骨に異なる役割を果たす. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2023. 41st
池田悠希, 谷彰一郎, 森石武史, 黒田愛子, 松尾友紀, 乾千珠子, 阿部真土, 前田隆史, 鄭雄一, 北條宏徳, et al. ヒト多能性幹細胞による膜内骨化再現系の開発. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2023. 128th

ｍore...

Education (3)：

2007 - 2011 The University of Tokyo Graduate School of Medicine
2005 - 2007 Kanazawa University Graduate School of Natural Science and Technology Division of Pharmaceutical Sciences
2001 - 2005 Kanazawa University School of Pharmacy

Professional career (1)：

PhD (The University of Tokyo)

Work history (7)：

2019 - 現在 Associate Professor, Center for Disease Biology and Integrative Medicine, the University of Tokyo
2017 - 2019 Assistant Professor, Center for Disease Biology and Integrative Medicine, the University of Tokyo
2016 - 2017 Project Assistant Professor, Department of Bioengineering, Graduate School of Engineering, the University of Tokyo
2014 - 2016 Postdoctoral Fellowship for Research Abroad, Japan Society for Promotion of Science
2012 - 2016 Postdoctoral Fellow, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California

Show all

Awards (4)：

2020 - 日本骨代謝学会優秀演題賞
2019 - The American Society for Bone and Mineral Research Rising Star Awards
2015 - The American Society for Bone and Mineral Research Young Investigator Awards
2012 - The American Society for Bone and Mineral Research Young Investigator Travel Grant

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page