Hojo Hironori

ホウジョウヒロノリ | Hojo Hironori

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://grn.tokyo/med/ , https://grn.tokyo/med/en/

Research field (1)： Biomedical engineering

Research keywords (5)： Skeletal development and regeneration , Enhancer landscape , Omics analysis , Human Pluripotent Stem Cells , CRISPR technology

Research theme for competitive and other funds (31)：

2024 - 2027 The mechanism of joint homeostasis in the coupling of articular cartilage and synovium
2023 - 2027 関節の恒常性を司る、滑膜と軟骨の連関制御機構の解明
2023 - 2026 Foxc1によるFgfr2発現機構の解明
2022 - 2025 Study on the role of sulfur respiration in homeostasis and disruption of the skeletal system under hypoxic conditions
2022 - 2025 Evaluation of properties by epigenome analysis for human umbilical cord-derived stromal cells and research for bone regenerative medicine

2022 - 2025 Sp7-Dlx相互作用の顎顔面骨再生における機能の解明と歯科矯正治療への応用

2021 - 2025 ヒト骨発生機構の理解に基づく組織再生研究基盤の構築

2021 - 2025 Comprehensive understanding of the enhancer cluster that regulates the expression of Indian hedgehog in the skeletal system

2021 - 2025 Comprehensive understanding of the enhancer cluster regulating the expression of Indian hedgehog in the skeletal system

2022 - 2024 Development of effective tissue regeneration method based on single cell genomics of neural crest derived cell

2021 - 2024 一細胞CRISPRスクリーニング法を駆使した機能的GWAS-SNP検出法の確立

2021 - 2024 Prohibitinの軟骨分化機能解析とその知見を用いた変形性関節症薬の探索

2020 - 2024 骨発生・骨修復におけるエピゲノムダイナミクスの比較解析と骨再生への応用

2021 - 2023 Investigation of the mechanism of actions of the helioxanthin-derivative and its application as a multi-kinase inhibitor

2021 - 2023 Development of bone regeneration methods based on understanding of tissue remodeling

2018 - 2021 In vitro modeling of human bone metabolism using pluripotent stem cell-derived bone organoids

2018 - 2021 Development of functional enhancer screening system by integrating genome editing technology with single-cell RNA-seq

2018 - 2021 Elucidation of stem cell signal using genome structure as an index and application to bone regenerative medicine

2017 - 2021 Fundamental study of bone regeneration with site-specific epigenome editing

2016 - 2021 Development of 4-dimensional scaffold system that integrates signaling factors and 3-dimensional structural biomaterials

2017 - 2020 Identification of regulatory factors contributing to migration or recruitment of osteoblast progenitors by genome-wide approach and the application for bone repair

2017 - 2020 Understanding of Runx2-mediated hierarichical gene regulatory network in bone formation and application of the network for bone regeneration

2017 - 2020 Identification of osteoclast-supporting cells and the investigation of the in vivo functions of the cells using mouse ES cells

2017 - 2019 転写因子Runx2を中心とする階層的骨形成転写ネットワークの解明とその応用

2015 - 2018 Identification of the molecular network regulating movement of Hedgehog proteins on cell surface during skeletal development

2014 - 2018 Dynamics of epigenome and transcription during the Hedgehog signaling-mediated specification of skeletal cells

2018 - ゲノム編集技術と一細胞RNA-seq解析を融合した機能的エンハンサー探索法の開発

2011 - 2013 新規器官培養系を用いた骨軟骨前駆細胞の分化決定制御機構の解明と骨再生療法への応用

2011 - 新規器官培養系を用いた骨軟骨前駆細胞の分化決定制御機構の解明と骨再生療法への応用

2008 - 2010 バイオ・ナノ融合テクノロジーを基盤とした新規的な骨・軟骨誘導剤の開発

2008 - バイオ・ナノ融合テクノロジーを基盤とした新規的な骨・軟骨誘導剤の開発

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Papers (77)：

Dahlia Eldeeb, Yuki Ikeda, Hironori Hojo, Shinsuke Ohba. Unraveling the hidden complexity: Exploring dental tissues through single-cell transcriptional profiling. Regenerative Therapy. 2024
Hironori Hojo, Shoichiro Tani, Shinsuke Ohba. Modeling of Skeletal Development and Diseases Using Human Pluripotent Stem Cells. Journal of Bone and Mineral Research. 2024
Jinyan Si, Shohei Ishikawa, Shant Nepal, Hiroyuki Okada, Ung-il Chung, Takamasa Sakai, Hironori Hojo. Osteogenic differentiation capabilities of multiarm PEG hydrogels: involvement of gel-gel-phase separation in cell differentiation. Polymer Journal. 2024
Dahlia Eldeeb, Hiroyuki Okada, Yutaka Suzuki, Masahide Seki, Junichi Tanaka, Kenji Mishima, Ung-Il Chung, Shinsuke Ohba, Hironori Hojo. Exploring the Role of DNMT1 in Dental Papilla Cell Fate Specification during Mouse Tooth Germ Development through Integrated Single-Cell Transcriptomics and Bulk RNA Sequencing. Journal of oral biosciences. 2024
Shant Nepal, Jinyan Si, Shohei Ishikawa, Masaki Nishikawa, Yasuyuki Sakai, Aya M. Akimoto, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Takamasa Sakai, et al. Injectable phase-separated tetra-armed poly(ethylene glycol) hydrogel scaffold allows sustained release of growth factors to enhance the repair of critical bone defects. Regenerative Therapy. 2024. 25. 24-34

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MISC (63)：

行森茜, 田中準一, 北條宏徳, 安原理佳, 鯨岡聡子, 石田尚子, 大庭伸介, 美島健二. ChIP-seqを用いた胎生期マウス顎下腺組織におけるFoxc1による発現制御遺伝子の網羅的解析. 日本病理学会会誌. 2023. 112. 1. 292-292
山下裕輔, 金英一, 中村唱乃, 粟田ちひろ, 金武祚, 北浦義昭, 鄭雄一, 北條宏徳, 大庭伸介. 骨形成促進作用を有する卵黄由来ペプチドVNPEの発見(その1 ペプチド探索と体内動態). 日本栄養・食糧学会大会講演要旨集. 2023. 77回. 288-288
金英一, 山下裕輔, 中村唱乃, 粟田ちひろ, 金武祚, 北浦義昭, 鄭雄一, 北條宏徳, 大庭伸介. 骨形成促進作用を有する卵黄由来ペプチドVNPEの発現(その2 モデル動物における生理活性評価). 日本栄養・食糧学会大会講演要旨集. 2023. 77回. 289-289
岡田寛之, 岡田寛之, 岡田寛之, 照井悠太, 小俣康徳, 小俣康徳, 関真秀, 谷彰一郎, 谷彰一郎, 谷彰一郎, et al. 運動器発のサブセルラーシーケンスで,細胞生物学の常識に挑む. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2023. 41st
岡田寛之, 岡田寛之, 岡田寛之, 照井悠太, 小俣康徳, 小俣康徳, 関真秀, 谷彰一郎, 谷彰一郎, 宮原潤也, et al. 1生細胞内シーケンスで多核巨細胞の遺伝子発現制御に挑む. 日本生化学会大会(Web). 2023. 96th

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Education (3)：

2007 - 2011 The University of Tokyo Graduate School of Medicine
2005 - 2007 Kanazawa University Graduate School of Natural Science and Technology Division of Pharmaceutical Sciences
2001 - 2005 Kanazawa University School of Pharmacy

Professional career (1)：

PhD (The University of Tokyo)

Work history (7)：

2019 - 現在 Associate Professor, Center for Disease Biology and Integrative Medicine, the University of Tokyo
2017 - 2019 Assistant Professor, Center for Disease Biology and Integrative Medicine, the University of Tokyo
2016 - 2017 Project Assistant Professor, Department of Bioengineering, Graduate School of Engineering, the University of Tokyo
2014 - 2016 Postdoctoral Fellowship for Research Abroad, Japan Society for Promotion of Science
2012 - 2016 Postdoctoral Fellow, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California

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Awards (4)：

2020 - 日本骨代謝学会優秀演題賞
2019 - The American Society for Bone and Mineral Research Rising Star Awards
2015 - The American Society for Bone and Mineral Research Young Investigator Awards
2012 - The American Society for Bone and Mineral Research Young Investigator Travel Grant

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