Hozumi Isao

ホズミイサオ | Hozumi Isao

Affiliation and department：
Other affiliations (1)：

Research field (1)： Neurology

Research theme for competitive and other funds (15)：

2019 - 2024 Studies on stem cell differentiation and growth process in neurodegenerative diseases focusing on biometals
2017 - 2021 Research on the molecular mechanism of intracranial calcification and novel therapies
2017 - 2020 Novel therapeutic strategies for amyotrophic lateral sclerosis using human deciduous dental pulp stem cells and their active ingredients
2016 - 2019 Investigation on pathomechanism and treatment of canine degenerative myelopathy using disease-specific iPS cell
2015 - 2017 Pathogenic mechanism of neurodegenerative diseases associated with dysfunction of ubiquitin ligase

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Papers (86)：

Hisaka Kurita, Haruka Masuda, Ayu Okuda, Suzuna Go, Kazuki Ohuchi, Hiroki Yoshioka, Masatake Fujimura, Isao Hozumi, Masatoshi Inden. Epigenetic alternations in the SYP and DLG4 genes due to low-level methylmercury exposure during neuronal differentiation in vitro. Journal of applied toxicology : JAT. 2024
Hisaka Kurita, Naoki Hirasawa, Saori Yabe, Ayu Okuda, Takanori Murakami, Kazuki Ohuchi, Aya Ogata, Hiroki Yoshioka, Akiyoshi Kakita, Isao Hozumi, et al. MicroRNA-5572 Is Associated with Endoplasmic Reticulum Stress Responses in Low Zinc Treated and SOD1 G85R-Transfected HEK293 Cells. Biological & pharmaceutical bulletin. 2024. 47. 10. 1717-1725
Junya Murata, Kazuki Ohuchi, Yuto Murayama, Ayane Mishima, Hisaka Kurita, Isao Hozumi, Masatoshi Inden. TIC10/ONC201 Enhances Phosphate Uptake in the Human Neuroblastoma Cell Line SH-SY5Y. BPB Reports. 2024. 7. 4. 96-100
Hisaka Kurita, Misa Ueda, Miyu Kimura, Ayu Okuda, Kazuki Ohuchi, Isao Hozumi, Masatoshi Inden. Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway. Biological & pharmaceutical bulletin. 2024. 47. 4. 796-800
Ayaka Fujimaki, Kazuki Ohuchi, Shinnosuke Takizawa, Takanori Murakami, Hisaka Kurita, Isao Hozumi, Xiaopeng Wen, Yoshihisa Kitamura, Zhiliang Wu, Yoichi Maekawa, et al. The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells. Scientific Reports. 2023. 13. 1

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MISC (96)：

中島健二, 祖父江元, 長谷川一子, 饗場郁子, 青木正志, 阿部康二, 池内健, 小野寺理, 梶龍兒, 吉良潤一, et al. Huntington病の診断、治療、療養の手引き. 神経治療学. 2020. 37. 1. 61-104
山田恵, 田中真生, 金子雅幸, 二宮勇平, 栗田尚佳, 位田雅俊, 林祐一, 石浦浩之, 三井純, 岩田淳, et al. 本邦における特発性基底核石灰化症(IBGC)の臨床的・遺伝学的検討(第2報). 臨床神経学. 2016. 56. Suppl. S287-S287
Sekine S, Kondo T, Miki K, Yoshida Y, Kurita H, Inden M, Hozumi I, Inoue H. Modeling idiopathic basal ganglia calcification using patient iPSCs. 57th Annual Meeting of the Japanese Society of Neurology, Kobe. 2016
亀井孝紀, 位田雅俊, 関根信一郎, 栗田尚佳, 柴田敏之, 保住功. 家族性特発性基底核石灰化症の患者由来iPS細胞の作製と機能解析. 日本薬学会年会要旨集. 2016. 136年会. 3. 163-163
山田恵, 田中真生, 高木麻里, 小林清樹, 田口芳治, 高嶋修太郎, 田中耕太郎, 峠哲男, 初田裕幸, 村山繁雄, et al. 本邦における特発性大脳基底核石灰化症の臨床的・遺伝学的検討. 臨床神経学. 2014. 54. Suppl. S66-S66

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Professional career (1)：

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