Miki Toshio

ミキトシオ | Miki Toshio

Affiliation and department：
Job title： Professor

Research field (2)： Clinical pharmacy , Physiology

Research keywords (5)： Cell Transplantation , Hepatocyte , Stem cells , Amniotic epithelial cell , Regenerative Medicine

Research theme for competitive and other funds (6)：

2022 - 2025 細胞間ミトコンドリア移送開始シグナルの解明
2022 - 2025 ブタを用いた羊膜上皮幹細胞の門脈内移植後体内動態及び機能評価
2022 - 2025 羊膜由来幹細胞が肝内膵島生着環境に与える影響の解明
2020 - 2023 先天代謝異常症に対する羊膜上皮細胞治療の開発
2019 - 2021 羊膜上皮細胞由来エクソソーマル miR483-5p による肝星細胞活性制御機序の解明

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Papers (22)：

Masahiro Ogawa, Mitsuhiko Moriyama, Yutaka Midorikawa, Hitomi Nakamura, Toshikatu Shibata, Kazumichi Kuroda, Hisashi Nakayama, Kazunori Kanemaru, Toshio Miki, Masahiko Sugitani, et al. The significance of CDT1 expression in non-cancerous and cancerous liver in cases with hepatocellular carcinoma. Journal of Clinical Biochemistry and Nutrition. 2023. 73. 3. 234-248
Mitsuhiko Moriyama, Tatsuo Kanda, Yutaka Midorikawa, Hiroshi Matsumura, Ryota Masuzaki, Hitomi Nakamura, Masahiro Ogawa, Shunichi Matsuoka, Toshikatu Shibata, Motomi Yamazaki, et al. The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma. Scientific Reports. 2022. 20508
Taiko I, Takano C, Nomoto M, Hayashida S, Kanemaru K, Miki T. Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria. Scientific Reports. 2022. 12. 19841
Takano C, Horie M, Taiko I, Trinh QD, Kanemaru K, Komine-Aizawa S, Hayakawa S, Miki T. Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells. Stem Cell Reviews and Reports. 2022. 18. 8. 3083-3091
Abe S, Kaida A, Kanemaru K, Nakazato K, Yokomizo N, Kobayashi Y, Miura M, Miki T, Hidai C, Kitano H, et al. Differences in the stemness characteristics and molecular markers of distinct human oral tissue neural crest-derived multilineage cells. Cell Proliferation. 2022. 55. 10. e13286

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Lectures and oral presentations (17)：

ミトコンドリアの細胞間水平移動と再生医療への新展望
(第24回協和キリン腎臓シンポジウム 2023)
シングルセル解析を用いたヒト羊膜上皮細胞の系統学的多様性の解明
(第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会 2023)
Effect of human Amniotic Epithelial Cells on intraportal islet transplantation
(2023-IPITA-IXA-CTRMS 2023)
Single-cell transcriptomes reveal phylogenetic diversification of human amniotic epithelial cells
(2023-IPITA-IXA-CTRMS 2023)
Unlocking the Potential of Amniotic Epithelial Cells: Past Achievements and Future Prospects
(2023-IPITA-IXA-CTRMS 2023)

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Education (1)：

- 1992 Nihon University 医学部医学科

Professional career (1)：

医学博士 (日本大学)

Work history (4)：

2019/04 - 現在日本大学医学部生体機能医学系生理学分野教授
2011/01 - 2019/03 University of Southern California Stem Cell/Biochemistry/Surgery Associate Professor
1998/04 - 2010/12 University of Pittsburhgh Transplant surgery/Pathology/Regenerative medicine Postdoctoral fellow/assistant professor
1992/04 - 1998/03 Nihon University School of Medicine Surgery

Committee career (3)：

2023/11 - 2025/10 Cell Transplant and Regenerative Medicine Society President
2021 - 2023 Cell Transplant and Regenerative Medicine Society President elect
2017 - 2021 Cell Transplant and Regenerative Medicine Society Councilor

Awards (2)：

2011 - Nihon University University Alumni Award
2000 - American Society of Transplant Surgeons Young Investigator Award

Association Membership(s) (8)：

日本細胞外小胞学会 , 肝細胞研究会 , JAPAN SURGICAL SOCIETY , THE JAPAN SOCIETY FOR MEDICAL EDUCATION , THE JAPAN SOCIETY FOR TRANSPLANTATION , THE PHYSIOLOGICAL SOCIETY OF JAPAN , Cell Transplant and Regenerative Medicine Society , 日本先天代謝異常学会

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