Rchr
J-GLOBAL ID：201901013553287146
Update date: Jul. 17, 2024
Shimokawa Noriaki
Shimokawa Noriaki
Affiliation and department：
Research field (1)：
Physiology
Research theme for competitive and other funds (26)：
- 2023 - 2027 Elucidation of the mechanism of parental abandonment caused by perinatal stress
- 2022 - 2025 ネグレクト回避のための腸内環境の構築
- 2022 - 2025 脂肪細胞分化抑制因子EID1はヒト肝細胞への脂肪の蓄積を抑制するか
- 2021 - 2023 環境化学物質曝露により産生される異常な細胞外小胞による毒性発現メカニズムの解明
- 2020 - 2023 ネグレクトの抑制における分子作用機序の解明:乳汁成分とエピゲノム修飾の解析
- 2018 - 2022 Epigenetic modulation by chemical substances on thyroid hormone-mediated brain development.
- 2017 - 2020 Analysis of the fetal/uterine environment on nurturing behavior in the next generation: understanding the causes of neglect and its recovery
- 2016 - 2019 Comprehensive analysis of gene expression in congenital scoliosis
- 2014 - 2017 Establishment of disease due to CIN85 abnormality: Analysis of pathology and molecular variation of hyperactivity, maternal neglect and mental retardation
- 2013 - 2017 Effects of environmental factors on small lipophilic hormone-mediated development of brain function
- 2014 - 2016 A novel pathway of the differenciation of Beige cells - analisis of adipocyte specific EID1-overexpressed mice
- 2013 - 2016 Comprehensive analysis of gene expression in the spine of congenital kyphoscoliosis obtained using DNA microarrays
- 2012 - 2015 Whether hyperactivity disorder is genetic diseases or not? The establishment of gene diagnosis for hyperactivity disorder due to CIN85 abnormality.
- 2012 - 2014 胎児期における脳内環境の破綻と育児放棄の発症機序の解明
- 2009 - 2012 Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals.
- 2009 - 2011 Analysis of behavior disorder and the deficient rescue of CIN85 knockout mouse that shows hyperactivity and rearing neglect to newborns
- 2008 - 2009 トランスポートソームの機能破綻による神経性異常とヒトにおける病態解析
- 2006 - 2008 Analysis of behavioral quantity by the loss of function of CIN85 related to receptor endocytosis
- 2005 - 2008 Molecular mechanisms generating a critical period of thyroid hormone action on brain development and its modulation by environmental chemicals
- 2006 - 2007 受容体の膜輸送を制御する分子複合体構成蛋白質CIN85の役割と機能欠失の解析
- 2002 - 2004 Analysis of knockout mouse of a brain-specific H^+ transporter ASPT.
- 2002 - 2004 The role of thyroid hormone action in the developing brain and the mechanism generating critical period of its action.
- 1999 - 2001 Gene targeting approach to study functions on respiratory and circulatory regulation of novel H^+ Channel
- 1997 - 1998 核内転写因子AP-1欠損マウスによる胎仔神経細胞の非分裂化の解析と欠損修復の試み
- 1996 - 1996 胎仔神経細胞の非分裂化におけるfos/junの役割とその発現細胞の分離・培養
- 1995 - 1995 潰瘍発現性薬物によりFosを発現する神経細胞の分離・培養とそのCRH分泌特性
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Papers (74)：
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Taku James Sairenji, Shinnosuke Masuda, Yuya Higuchi, Mitsue Miyazaki, Hiroyuki Yajima, Oh Kwan Ee, Yuki Fujiwara, Takuya Araki, Noriaki Shimokawa, Noriyuki Koibuchi. Plasma prolactin axis shift from placental to pituitary origin in late prepartum mice. Endocrine journal. 2024
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Shinnosuke Masuda, Oh Kwan Ee, Taku James Sairenji, Seika Sato, Hiroyuki Yajima, Izuki Amano, Noriyuki Koibuchi, Noriaki Shimokawa. Maternal prolactin levels during late pregnancy and nurturing behavior of offspring in mice. Developmental psychobiology. 2022. 64. 3. e22264
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大野 洋一, 下川 哲昭, 鯉淵 典之. ラットに対する長期的な運動負荷が酸化ストレスおよび抗酸化力に与える影響の検証. The Japanese Journal of Rehabilitation Medicine. 2021. 58. 秋季特別号. S520-S520
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Tomohiko Sato, Diana Vargas, Kakushin Miyazaki, Kaoru Uchida, Winda Ariyani, Mitsue Miyazaki, Junichi Okada, Fernando Lizcano, Noriyuki Koibuchi, Noriaki Shimokawa. EID1 suppresses lipid accumulation by inhibiting the expression of GPDH in 3T3-L1 preadipocytes. Journal of cellular physiology. 2020. 235. 10. 6725-6735
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Sho Ishiwata, Haku Iizuka, Hiroyuki Sonoda, Daisuke Tsunoda, Yuki Tajika, Hirotaka Chikuda, Noriyuki Koibuchi, Noriaki Shimokawa. Upregulated miR-224-5p suppresses osteoblast differentiation by increasing the expression of Pai-1 in the lumbar spine of a rat model of congenital kyphoscoliosis. Molecular and cellular biochemistry. 2020. 475. 1-2. 53-62
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MISC (15)：
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大野洋一, 高橋樹, 下川哲昭, 鯉淵典之. ラットに対する有酸素運動および無酸素運動による長期介入が脳内および血中酸化ストレス動態に与える影響. 日本酸化ストレス学会学術集会プログラム・抄録集. 2022. 75th (CD-ROM)
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大野洋一, 下川哲昭, 鯉淵典之. ラットに対する長期的な運動負荷が酸化ストレスおよび抗酸化力に与える影響の検証. Japanese Journal of Rehabilitation Medicine. 2021. 58. Autumn
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Shimokawa N, Masuda S, Masuda H, Koibuchi N. CIN85 defect in brain and neurobehavioral disorder: involvement in excess dopamine signaling. Hormonal Studies. 2013. 1
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Hideka Hayashi, Anri Azuma, Hiroyuki Mizuno, Shinosuke Masuda, Yu Lu, Ronny Lesmana, Asahi Haijima, Yusuke Takatsuru, Toshiharu Iwasaki, Noriaki Shimokawa, et al. Effect of oral administration of thyroxine on cerebellar function in congenital hypothyroid(rdw)rat. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S214-S214
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Xu, M, Sulkowski, Z. L, Parekh, P, Khan, A, Chen, T, Midha, S, Iwasaki, T, Shimokawa, N, Koibuchi, N, Zavacki, A. M, et al. Effects of Perinatal Lipopolysaccharide (LPS) Exposure on the Developing Rat Brain; Modeling the Effect of Maternal Infection on the Developing Human CNS. CEREBELLUM. 2013. 12. 4. 572-586
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Professional career (1)：
Work history (1)：
- 2014/10 - 現在 Takasaki University of Health and Welfare
Association Membership(s) (1)：
THE PHYSIOLOGICAL SOCIETY OF JAPAN
