Shiimura Yuki

シイムラユウキ | Shiimura Yuki

Affiliation and department：
Other affiliations (1)：

Graduate School of Medicine, Kyoto University Department of Cell Biology

Research field (4)： Medical biochemistry , Metabolism and endocrinology , Pharmacology , Structural biochemistry

Research keywords (5)： GPCR , Ghrelin , Ghrelin receptor (GHSR) , Protein engineering , DNA-encoded Library

Research theme for competitive and other funds (13)：

2024 - 2028 Structural study of the initial transducer engagement by GPCR
2023 - 2026 Development of Next-Generation GPCR-Targeted Drugs by Integrating Protein Engineering and Medicinal Chemistry
2022 - 2026 グレリン受容体のシグナル伝達選択機構の構造基盤
2022 - 2025 膜結合型酵素によるグレリン活性化機構の解明
2023 - 2025 Gタンパク質共役型受容体のバイアスドリガンドの探索

Show all

Papers (15)：

Dohyun Im, Mika Jormakka, Narinobu Juge, Jun-Ichi Kishikawa, Takayuki Kato, Yukihiko Sugita, Takeshi Noda, Tomoko Uemura, Yuki Shiimura, Takaaki Miyaji, et al. Neurotransmitter recognition by human vesicular monoamine transporter 2. Nature communications. 2024. 15. 1. 7661-7661
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, et al. A μ-opioid receptor modulator that works cooperatively with naloxone. Nature. 2024. 631. 8021. 686-693
Takanori Ida, Hatsumi Tominaga, Eri Iwamoto, Akito Kurogi, Ayaka Okura, Kengo Shimada, Johji Kato, Atsutoshi Kuwano, Hirotaka Ode, Sayaka Nagata, et al. Acyl modifications in bovine, porcine, and equine ghrelins. Frontiers in endocrinology. 2024. 15. 1411483-1411483
Dohyun Im, Jun-Ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, et al. Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor. Nature communications. 2023. 14. 1. 6538-6538
Takahiro Sato, Takanori Ida, Yuki Shiimura, Kazuma Matsui, Kanae Oishi, Masayasu Kojima. Insights Into the Regulation of Offspring Growth by Maternally Derived Ghrelin. Frontiers in endocrinology. 2022. 13. 852636-852636

ｍore...

MISC (9)：

佐藤貴弘, 井田隆徳, 椎村祐樹, 児島将康. Mediators of inter-organ communication-Bioactive peptides. 循環器内科. 2022. 92. 6
佐藤貴弘, 椎村祐樹, 梶谷宇, 岩田想, 児島将康. 食欲制御のコンダクター:グレリン. 生体の科学. 2021. 72. 5
椎村祐樹, 児島将康. グレリン受容体のX線結晶構造解析から分かったこと. 亜鉛栄養治療. 2021. 11. 2. 258-261
Yuki Shiimura, So Iwata, Masayasu Kojima. Protein Crystallography: Crystal structure of an antagonist-bound ghrelin receptor. Spring-8/SACLA Research Frontiers 2020. 2021. 18-19
椎村祐樹, 佐藤貴弘, 児島将康. 分泌タンパク質オクタノイル化. 生体の科学. 2018

ｍore...

Lectures and oral presentations (1)：

Structural Insights into Ghrelin Receptor
(JKT Symposium on "The 5Gs in Obesity (GLP-1, GIP, Glucagon, Ghrelin and Gut hormone):Basic and Clinical Research" 2023)

Education (3)：

2011 - 2015 Kurume University Graduate School of Medicine
2007 - 2009 Kagoshima University Graduate School of Medical and Dental Sciences
2003 - 2007 Kyushu University of Health and Welfare School of Pharmaceutical Sciences

Professional career (1)：

博士(医学) (久留米大学)

Work history (7)：

2017/04 - 現在 Graduated school of medicine, Kyoto university Cell Biology Visiting Scholar
2017/04 - 現在 Kurume University Molecular Genetics, Institute of Life Science
2023/06 - 2023/12 School of Medicine, Stanford University Molecular and Cellular Physiology (Kobilka Lab)
2021/09 - 2022/08 School of Medicine, Stanford University Molecular and Cellular Physiology (Kobilka lab) Visiting Scholar
2016/04 - 2017/03 Kyoto University Graduate School of Medicine

Show all

Committee career (2)：

2024/07 - 現在 The Japan Endocrine Society Young Endocrinologist Conference
2024/10 - 2026/07 11th International Congress of Neuroendocrinology ICN2026 Emerging Researchers Committee

Awards (4)：

2024/07 - 内分泌学会内分泌代謝学サマーセミナーポスター賞
2023/11 - 日本心血管内分泌代謝学会高峰譲吉研究奨励賞
2019/05 - GPCR研究会松尾研究奨励賞
2018/04 - The Japan Endocrine Society Young Investigator Award

Association Membership(s) (7)：

日本心脈管作動物質学会 , The Japanese Pharmacological Society , 日本肥満学会 , The Society of Cardiovascular Endocrinology and Metabolism , Japan Neuroendocrine Society , The Pharmaceutical Society of Japan , The Japan Endocrine Society

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page