2022 - 2025 Investigation of virus RNA analysis using FFPE specimens to clarify the pathogenesis of acute rupture of chodae tendineae of the mitral valve in infants
2022 - 2025 Research for Risk Stratification of cerebral hemorrhage
2021 - 2024 心筋内炎症の鍵となる介在板分子は拡張型心筋症の予後を規定するか?
2021 - 2024 A multi-omics study to elucidate the novel molecular basis of the complex traits and ethnicity in Brugada syndrome
2021 - 2024 心臓前駆細胞の発生を制御するエピジェネティック因子と転写因子のクロストーク
2020 - 2023 Development of a high-precision diagnostic method for heart failure utilizing abnormal biosynthesis of beta-atrial natriuretic peptide in the failing heart
2020 - 2023 Positional and quantitative regulation of the central nervous cells by interaction of pattern formation, proliferation and differentiation timing
2019 - 2022 Analysis of epigenetic disruption in cardiomyocyte senescence and disease.
2019 - 2022 Transcroiptome and Metagenome Analysis of Patients with Acute Rupture of Chordae Tendeneae of the Mitral Valve in Infants
2018 - 2021 Epigenetic regulation of cardiac progenitor cells development in lateral plate mesoderm/pharyngeal region.
2015 - 2018 Functional analysis of Polycomb group proteins in adult heart
2015 - 2018 Research on Pathogenesis of Acute Rupture of Chordae Tendinae of the Mitral Valve in Infants: Possible involvement of maternally derived anti-SSA antibody
2015 - 2017 Detection of cell-cycling cardiac muscle cells by visualizing Geminin, and regeneration of cardiac muscle cells
2013 - 2015 Molecular role for Geminin in maintaining cardiac muscles
2012 - 2015 Functional analysis of Polycomb-group genes in regulating mechanisms for self-reneual and differentiation of cardiac progenitor cells.
2011 - 2012 Detection and functional analysis of cardiac stem cells
2009 - 2011 Functional analysis of Polycomb-group gene, Pcgf5 in cardiac morphogenesis
2005 - 2006 Isolation and analysis of transcription factors associated with Nkx2-5 and cardiac differentiation
2004 - 2005 Genetic analysis of Primary Pulmonary Hypertension and possible involvement of Tbx genes via BMP signaling in the pathogenesis of PPH.
1999 - 2000 Gene Regulation in Cardiac Development
1998 - 1999 マウス心臓発生におけるPolycomb group遺伝子群の役割の解析
1996 - 1997 細胞分化の新しい制御機構の分子レベル及び個体レベルでの解析
1995 - 1997 GENERATION OF MOUSE MODELS FOR HUMAN GENETIC DISEASESTHROUGH GENE TARGETING
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Papers (38)：
Tomohiko Ishibashi, Tadakatsu Inagaki, Makoto Okazawa, Akiko Yamagishi, Keiko Ohta-Ogo, Ryotaro Asano, Takeshi Masaki, Yui Kotani, Xin Ding, Tomomi Chikaishi-Kirino, et al. IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 16. e2315123121
Maho Yamamoto, Agnes Lee Chen Ong, Takuma Shinozuka, Manabu Shirai, Noriaki Sasai. Manipulation of Signal Gradient and Transcription Factors Recapitulates: Multiple Hypothalamic Identities. Stem cells (Dayton, Ohio). 2023. 41. 5. 453-467
Maho Yamamoto, Agnes Ong Lee Chen, Takuma Shinozuka, Manabu Shirai, Noriaki Sasai. Hedgehog Activity Gradient in Combination with Transcription Network Confers Multiple Hypothalamic Identities. 2022
Kyung-Duk Min, Masanori Asakura, Manabu Shirai, Satoru Yamazaki, Shin Ito, Hai Ying Fu, Hiroshi Asanuma, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, et al. ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis. Scientific reports. 2021. 11. 1. 23056-23056
Yuka Kobayashi, Shizuka Watanabe, Agnes Lee Chen Ong, Manabu Shirai, Chiemi Yamashiro, Tadahiko Ogata, Fumiaki Higashijima, Takuya Yoshimoto, Takahide Hayano, Yoshiyuki Asai, et al. Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina. Disease models & mechanisms. 2021. 14. 11
Yoh Arita, Yoshikazu Nakaoka, Taichi Marsunaga, Hiroyasu Kidoya, Kohei Yamamizu, Yuichiro Arima, Kaori Higuch, Manabu Shirai, Taku Yasui, Kuniyasu Ikeoka, et al. Angiopoietin-1 is Essential for Coronary Vein Formation in the Developing Heart. CIRCULATION. 2012. 126. 21
M Sano, M Shirai, DJ Rossi, TP Makela, GE Taffet, KA Youker, LH Michael, ML Entman, RJ Schwartz, MD Schneider. RNA polymerase II C-terminal domain kinases in heart failure. CIRCULATION. 2003. 108. 17. 159-159
M Sano, M Shirai, DJ Rossi, TP Makela, GE Taffet, KA Youker, LH Michael, ML Entman, RJ Schwartz, MD Schneider. RNA polymerase II C - Terminal domain kinases in heart failure. CIRCULATION. 2003. 108. 17. J-J
