Hiroki Hayano

Affiliation and department：

Research field (1)： Prosthodontics

Research theme for competitive and other funds (1)：

2020 - 2023 Exploration of pathogenesis of medication-related osteonecrosis of the jaw based on macrophages

Papers (12)：

Rhyohei Kozutsumi, Shinichiro Kuroshima, Farah A. Al-Omari, Hiroki Hayano, Kazunori Nakajima, Hiroe Kakehashi, Takashi Sawase. Response to letter to the editor regarding, “Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice”. Bone. 2024. 181. 117010-117010
Ryohei Kozutsumi, Shinichiro Kuroshima, Farah A. Al-Omari, Hiroki Hayano, Kazunori Nakajima, Hiroe Kakehashi, Takashi Sawase. Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice. Bone. 2023. 116899-116899
Haruka Kaneko, Shinichiro Kuroshima, Ryohei Kozutsumi, Farah A Al-Omari, Hiroki Hayano, Kazunori Nakajima, Takashi Sawase. Zoledronate/Anti-VEGF Neutralizing Antibody Combination Administration Increases Osteal Macrophages in a Murine Model of MRONJ Stage 0-like Lesions. Journal of clinical medicine. 2023. 12. 5
Shinichiro Kuroshima, Kazunori Nakajima, Muneteru Sasaki, Hiroki Hayano, Maaya Inoue, Ryohei Kozutsumi, Takashi Sawase. Gene expression analysis of fresh extraction wounds prior to onset of bisphosphonate-related osteonecrosis of the jaw-like lesions in mice: A preliminary animal study. Journal of prosthodontic research. 2021. 65. 4. 546-553
Riho Kanai, Shinichiro Kuroshima, Michimasa Kamo, Muneteru Sasaki, Yusuke Uto, Nao Inaba, Yusuke Uchida, Hiroki Hayano, Saki Tamaki, Maaya Inoue, et al. Effects of surface sub-micrometer topography following oxalic acid treatment on bone quantity and quality around dental implants in rabbit tibiae. International journal of implant dentistry. 2020. 6. 1. 75-75

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MISC (34)：

小堤涼平, 黒嶋伸一郎, 金子遥, 早野博紀, 澤瀬隆. Pathophysiology and pathology of a murine model of bisphosphonate-related osteonecrosis of the jaw stage 0-like lesions based on clinical perspective. 日本口腔インプラント学会誌. 2021. 34
黒嶋伸一郎, 佐々木宗輝, 中島和慶, 早野博紀, 井上真愛弥, 澤瀬隆. Correlation of gene profiles with histopathology and immunopathology in high-prevalence BRONJ-like lesions in mice. 日本補綴歯科学会誌(Web). 2020. 12
黒嶋伸一郎, 早野博紀, 佐々木宗輝, 中島和慶, 澤瀬隆. 高頻度発現型BRONJマウスモデルを用いた早期における遺伝子パターン解析. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2020. 38th
早野博紀, 黒嶋伸一郎, 玉城沙貴, 井上真愛弥, 澤瀬隆. 免疫病理組織所見が異なるビスホスホネート製剤と抗RANKL抗体誘発性顎骨壊死様病変. 第37回日本骨代謝学会学術集会.プログラム抄録集. 2019. 214-214
黒嶋伸一郎, 玉城沙貴, 早野博紀, 井上真愛弥, 澤瀬隆. 抗RANKL抗体製剤の休止が高頻度発現型マウス顎骨壊死様病変に与える影響. 第37回日本骨代謝学会学術集会.プログラム抄録集. 2019. 224-224

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Lectures and oral presentations (8)：

免疫病理組織所見が異なるビスホスホネート製剤と抗RANKL抗体誘発性顎骨壊死様病変
(2019)
骨吸収抑制薬と抗癌剤の併用投与がマウス抜歯窩治癒に与える影響
(第39回日本骨形態計測学会 2019)
Effects of antiresorptives/chemotherapeutic combination therapy on tooth extraction socket healing
(97th General session & Exhibition of the IADR 2019)
ビスフォスフォネート製剤とデノスマブ誘発性顎骨壊死の病因・病態は脈管形成依存性に異なる
(公益社団法人日本口腔インプラント学会第48回公益社団法人日本口腔インプラント学会学術大会 2018)
吸収抑制薬と抗癌剤の併用投与がマウスの抜歯窩治癒に与える影響
(第36回日本骨代謝学会学術集会 2018)

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Education (2)：

2016 - 現在 Nagasaki University
2009 - 2015 Nagasaki University School of Dentistry

Awards (2)：

2019/07 - 日本骨形態計測学会若手研究者賞骨吸収抑制薬と抗癌剤の併用投与がマウス抜歯窩治癒に与える影響
2018/09 - 公益社団法人日本口腔インプラント学会優秀研究発表賞ビスフォスフォネート製剤とデノスマブ誘発性顎骨壊死の病因・病態は脈管形成依存性に異なる

Association Membership(s) (4)：

JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH , JAPANESE SOCIETY FOR BONE MORPHOMETRY , JAPANESE SOCIETY OF ORAL IMPLANTOLOGY , JAPAN PROSTHODONTIC SOCIETY

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