Ishikawa Taisuke

イシカワタイスケ | Ishikawa Taisuke

Affiliation and department：

Research field (1)： Cardiology

Research keywords (12)： arrhythmia , cardiology , inherited arrhythmia , Brugada syndrome , Genome-Wide Association Study , electrophysiology , patch-calmp , genetic testing , gap junction , cardiac conduction disturbance , 分子心臓病態学 , human genetics

Research theme for competitive and other funds (10)：

2021 - 2024 A multi-omics study to elucidate the novel molecular basis of the complex traits and ethnicity in Brugada syndrome
2020 - 2023 Integrated analysis of pathgenesis of hereditary hemorrhagic telangiectasia
2020 - 2023 Elucidation of molecular pathogenesis for inherited lethal arrhythmia associated with transporter abnormalities
2018 - 2021 Ethnicity-oriented genomic analysis of pathogenesis underlysing sudden cardiac death of unknown cause
2019 - 2020 ブルガダ症候群における致死性不整脈発症に関連するゲノム領域の特定と個別化リスク予測法の樹立

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Papers (80)：

Taisuke Ishikawa, Tatsuo Masuda, Tsuyoshi Hachiya, Christian Dina, Floriane Simonet, Yuki Nagata, Michael W T Tanck, Kyuto Sonehara, Charlotte Glinge, Rafik Tadros, et al. Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci. European Heart Journal. 2024. 45. 26. 2320-2332
Manon Baudic, Hiroshige Murata, Fernanda M. Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E. van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, et al. TAD boundary deletion causes PITX2-related cardiac electrical and structural defects. Nature Communications. 2024. 15. 1
Taisuke Ishikawa, Hiroshi Aoki. Nav-igating the pathogenicity of candidate gene mutations: Spotlight on paralog Nav genes. Journal of Veterinary Internal Medicine. 2023. 37. 3. 791-792
Huang Hai, Makiyama Takeru, Shirai Manabu, Wakabayashi Masaki, Ishikawa Taisuke, Nishiuchi Suguru, Moriuchi Kenji, Gao Jingshan, Kashiwa Asami, Imamura Tomohiko, et al. ミスセンス変異Lmna-S143Pを有するLMNA関連心筋症のラットモデル(Rat Model of LMNA-related Cardiomyopathy Carrying a Missense Mutation, Lmna-S143P). 日本循環器学会学術集会抄録集. 2023. 87回. OE05-9
Yuki Nagata, Ryo Watanabe, Christian Eichhorn, Seiko Ohno, Takeshi Aiba, Taisuke Ishikawa, Yukiko Nakano, Yoshiyasu Aizawa, Kenshi Hayashi, Nobuyuki Murakoshi, et al. Targeted deep sequencing analyses of long QT syndrome in a Japanese population. PloS one. 2022. 17. 12. e0277242

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MISC (32)：

CHA Pei-Chieng, 高橋篤, 鎌倉令, 林研至, 八木原伸江, 中野由紀子, 斯波(原田)真理子, 石川泰輔, 園田桂子, 伊藤英樹, et al. 次世代シーケンス解析を用いた特発性心室細動の原因遺伝子同定. 日本人類遺伝学会大会プログラム・抄録集. 2021. 66th (CD-ROM)
KASHIWA Asami, MAKIYAMA Takeru, KOUJITANI Hirohiko, YAMAMOTO Yuta, YAMAMOTO Yuta, GAO Jingshan, HUANG Hai, IMAMURA Tomohiko, AIZAWA Takanori, ISHIKAWA Taisuke, et al. Late Sodium Current Inhibitor Shortens Prolonged Action Potential Durations in iPS Cell-derived Cardiomyocytes of long QT syndrome associated with Cav 1.2 Ion Selectivity Disruption. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
KOHJITANI Hirohiko, KASHIWA Asami, MAKIYAMA Takeru, ISHIKAWA Taisuke, TOYODA Futoshi, OHNO Seiko, HUANG Hai, GAO Jingshan, IMAMURA Tomohiko, AIZAWA Takanori, et al. Usefulness of Collaboration Between Mathematical Models and Cell Engineering for Elucidating Complex Disease Mechanisms and Discover Effective Drugs. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2021. 67th
KASHIWA Asami, MAKIYAMA Takeru, KOHJITANI Hirohiko, MAURISSEN Thomas, WURIYANGHAI Yimin, YAMAMOTO Yuta, GAO Jingshan, HUANG Hai, IMAMURA Tomohiko, AIZAWA Takanori, et al. Inhibition of Late Sodium Current Shortens Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 Ion Selectivity. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2021. 67th
YAMAMOTO Yuta, MAKIYAMA Takeru, KONDO Yoshiki, IRIYAMA Yusuke, WURIYANGHAI Yimin, KOHJITANI Hirohiko, GAO Jingshan, KASHIWA Asami, HUANG Hai, AIZAWA Takanori, et al. Antisense-Mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2021. 67th

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Books (6)：

ゼロから学ぶブルガダ症候群
大道学館出版部 2020
Precision medicine on hereditary arrhythmia by using next-generation sequencing
2020
Genetic background and molecular mechanisms of progressive cardiac conduction defect
Kagakuhyoronsha Co.,Ltd. 2018
ECG for cardiologists
Nankodo., Ltd. 2018
Genetic background and molecular mechanisms of inherited bradyarrhythmia
Kagakuhyoronsha Co.,Ltd. 2014

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Lectures and oral presentations (10)：

Cross-ancestry GWAS meta-analysis to elucidate risk genes for sudden death in Brugada syndrome.
(Japan-France Bilateral Seminar 2024: From Genes to Therapeutic Insights: Exploring the Genetic Landscape of Cardiac Arrhythmia 2024)
Population-specific and cross-ancestry GWAS for Brugada syndrome
(2023)
不整脈の分子生物学
(第115回日本獣医循環器学会 2021)
心臓刺激伝導系の分子生物学
(第111回日本獣医循環器学会 2020)
心臓突然死の発症リスク
(第9回奈良県不整脈臨床カンファレンス 2019)

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Education (2)：

2009 - 2013 Tokyo Medical and Dental Univeristy Graduate School of Medical and Dental Sciences Doctoral Program
2003 - 2009 Tokyo University of Agriculture and Technology Department of agriculture School of veterinary medicine

Professional career (1)：

博士(医学) (東京医科歯科大学大学院)

Work history (5)：

2024/05 - 現在 Kagoshima University Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine
2019/04 - 2021/09 National Cerebral and Cardiovascular Center Omics Research Center Laboratory manager in genomics
2017/10 - 2019/03 Nagasaki University Graduate school of Biomedical Sciences Senior Assistant Professor
2014/04 - 2017/09 Nagasaki University Graduate school of Biomedical Sciences Assistant Professor
2013/04 - 2014/03 Nagasaki University Graduate school of Biomedical Sciences Researcher

Committee career (2)：

2020/07 - 現在日本不整脈心電学会評議員
2016/04 - 現在日本生理学会評議員

Awards (4)：

2014/09 - The European Society of Cardiology Best Moderated Poster Award in ESC congress 2014 A novel cardiac α-myosin heavy chain (MYH6) mutation impairing sarcomere structure responsible for familial sick sinus syndrome
2014/03 - The Japanese Circulation Society Circulation Journal Awards for the Year 2013 Novel SCN3B Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.5
2013/10 - The Japanese Society of Electrocardiology Encouraging prize in the Japanese society of electrocardiology A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5.
2013/10 - The Physiological Society of Japan Encouraging prize

Association Membership(s) (5)：

HEART RHYTHM SOCIETY , Japanese Society of Veterinary Cardiology , JAPANESE HEART RHYTHM SOCIETY , THE PHYSIOLOGICAL SOCIETY OF JAPAN , The Japanese Circulation Society

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