Rchr
J-GLOBAL ID：201901015381011340   Update date: Aug. 01, 2024

Nishitsuji Kazuchika

ニシツジ カズチカ | Nishitsuji Kazuchika
Affiliation and department：
Wakayama Medical University Department of Biochemistry

About Wakayama Medical University Department of Biochemistry


Research field  (1)： Medical biochemistry
Research keywords  (12)： preeclampsia ,  胎盤形成 ,  p53 ,  卵巣癌 ,  糖鎖 ,  スルファターゼ ,  Alzheimer's disease ,  heparan sulfate ,  glycosaminoglycan ,  コンフォメーション病 ,  amyloidosis ,  amyloid
Research theme for competitive and other funds  (13)：
  • 2024 - 2027 Effests of p53 aggregates on tumor microenvironment in p53-mutated ovarian cancer
  • 2023 - 2026 細胞内脂肪滴蓄積を標的とした子宮頸癌の新たな予後予測と治療戦略
  • 2022 - 2025 p53アミロイドーシスとしてのp53遺伝子変異卵巣癌の病態メカニズムの解明
  • 2022 - 2025 Relationship between mitochondria-ER interaction in placental development
  • 2020 - 2023 Novel mechanism of amyloid beta-induced placentation defects
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Papers (79)：
  • Kazuchika Nishitsuji, Remi Mito, Midori Ikezaki, Hiromu Yano, Yukio Fujiwara, Eri Matsubara, Taro Nishikawa, Yoshito Ihara, Kenji Uchimura, Naoyuki Iwahashi, et al. Impacts of cytoplasmic p53 aggregates on the prognosis and the transcriptome in lung squamous cell carcinoma. Cancer science. 2024
  • Yoshiko Takeda-Uchimura, Midori Ikezaki, Tomoya O Akama, Yoshito Ihara, Fabrice Allain, Kazuchika Nishitsuji, Kenji Uchimura. GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated N-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium. Molecules (Basel, Switzerland). 2024. 29. 4
  • 西辻和親, 内村健治. Pathological roles of glycosaminoglycans in conformational diseases regulated by sulfation modifications. 生化学. 2024. 96. 2
  • Hiroyuki Yamada, Rin Yamada, Yoshihiro Komohara, Remi Mito, Kazuchika Nishitsuji, Hiromu Yano, Yukio Fujiwara, Koei Ikeda, Makoto Suzuki. A Case of Aggressive Lung Squamous Cell Carcinoma With Aberrant Cytoplasmic p53 Aggregation. Cancer diagnosis & prognosis. 2024. 4. 2. 204-208
  • Norihiro Namba, Takashi Ohgita, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Toshinori Shimanouchi, Takeshi Sato, Hiroyuki Saito. Amyloidogenic 60-71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects. Scientific Reports. 2023. 13. 1. 18514-18514
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MISC (72)：
  • Yoshiko Takeda-Uchimura, Shiori Go, Hirokazu Yagi, Kazuchika Nishitsuji, Hiroyuki Kaji, Yann Guérardel, Kenji Kadomatsu, Kenji Uchimura. Analysis of 5D4-reactive sialylated and sulfated glycans found in microglia in neurodegenerative diseases. Glyco-core Symposium 2024. 2024
  • Midori Ikezaki, Naoyuki Iwahashi, Masakazu Fujimoto, Noa Mori, Yoshito Ihara, Kazuhiko Ino, Kenji Uchimura, Kazuchika Nishitsuji. Analysis of CL40-reactive sialylated glycans in ovarian cancer associated with p53 aggregates. SialoGlyco 2024 13th International Conference on Biology and Chemistry of Sialic Acids. 2024. P13
  • Yoshiko Takeda-Uchimura, Markus Britschgi, Kazuchika Nishitsuji, Kenji Uchimura. Analysis of 5D4-reactive sialylated and sulfated glycan elicited in microglia in Parkinson’s disease mouse models. 2024. O37
  • 西辻 和親, 御任 玲美, 池崎 みどり, 藤原 章雄, 岩橋 尚幸, 井原 義人, 内村 健治, 菰原 義弘. p53変異癌における細胞内p53凝集体の予後への影響(Correlation of the presence of cytoplasmic p53 aggregates with poor prognosis in p53-mutated cancers). 日本病理学会会誌. 2024. 113. 1. 341-341
  • 原矢佑樹, 扇田隆司, 臼井明子, 西辻和親, 西辻和親, 内村健治, 阿部康弘, 川野竜司, KONAKLIEVA Monika I, REIMUND Mart, et al. Effect of conformational constraints on apolipoprotein E-derived amphipathic peptide: insight into cell membrane penetration. 日本薬学会年会要旨集(Web). 2024. 144th
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Patents (3)：
Books (1)：
  • アルツハイマー病発症メカニズムと新規診断法・創薬・治療開発
    (株)エヌ・ティー・エス 2018
Lectures and oral presentations  (2)：
  • Glycan-Mediated Prion-Like Behavior of Mutant p53 Aggregates and Their Possible Role in Cancer Pathogenesis
    (Glyco26 2023)
  • Glycosaminoglycans in protein aggregation diseases.
    (1st International Conference on the Glycobiology of Nervous System 2017)
Education (3)：
  • 2004 - 2008 Osaka City University Graduate School of Medicine
  • 2002 - 2004 京都大学大学院 薬学研究科
  • 1997 - 2001 Kyoto University Faculty of Pharmaceutical Sciences
Professional career (1)：
  • 医学博士
Work history (8)：
  • 2022/04 - 現在 Wakayama Medical University
  • 2018/06 - 2022/03 Wakayama Medical University
  • 2018/01 - 2018/05 徳島大学大学院医歯薬学研究部 疾患病理学 助教
  • 2013/01 - 2017/12 徳島大学大学院医歯薬学研究部 病態病理学 助教
  • 2011/04 - 2012/12 青山特許事務所
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Association Membership(s) (8)：
日本癌学会 ,  日本糖質学会 ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  日本アミロイドーシス学会 ,  Society for Neuroscience ,  THE MEMBRANE SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF PATHOLOGY ,  日本生化学会
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